Allergic contact dermatitis caused by dexpanthenol—Probably a frequent allergen

Fernandes, Rui; Santiago, Luís; Gouveia, Miguel; Gonçalo, Margarida

doi:10.1111/cod.13054

Cited by 25 publications

(16 citation statements)

References 10 publications

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“…However, a recent article by Fernandes et al evaluated 2171 patients to determine the frequency of ACD caused by panthenol 5% pet. ; they report a frequency of 1.2% positive test results 49 . Amongst those patients in whom relevance could be traced, three cases were due to moisturizers.…”

Section: Discussionmentioning

confidence: 93%

Developing a cosmetic series: Results from the ESSCA network, 2009‐2018

et al. 2020

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Background There is considerable variability across European patch test centres as to which allergens are included in local and national cosmetics series. Objectives To propose a standardized, evidence‐based cosmetic series for Europe based on up‐to‐date analysis of relevant contact allergens. Methods We collated data from the European Surveillance System on Contact Allergies (ESSCA) from 2009 to 2018 to determine which cosmetic allergens produce a high yield of contact allergy. Contact allergens with a prevalence of >0.3% that were considered relevant were included. Rare contact allergens were excluded if deemed no longer relevant or added to a supplemental cosmetic series for further analysis. Results Sensitization prevalences of 39 cosmetic contact allergens were tabulated. Thirty of these allergens yielded >0.3% positive reactions and are therefore included in our proposed European cosmetic series. Six were considered no longer relevant and therefore excluded. Three were included in a supplementary European cosmetic series. An additional nine allergens were included in either the core or supplemental European cosmetic series following literature review. Conclusion We have derived a potential European cosmetic series based upon the above methods. This will require ongoing investigation based upon the changing exposure profiles of cosmetic allergens as well as new and evolving substances.

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Section: Discussionmentioning

confidence: 93%

Developing a cosmetic series: Results from the ESSCA network, 2009‐2018

et al. 2020

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“…However, a case of systemic allergic dermatitis (flare up of hand eczema) after the ingestion of a nutritional supplement with it in a patient previously sensitized to dexpanthenol in a baby cream has been published 4 . On the other hand, contact dermatitis from D‐panthenol, a vitamin B5 alcohol analogue stereoisomer, has recently been the focus of several publications 5‐8 and its inclusion in cosmetic and topical drug patch tests series has been encouraged 6,7 . Immediate hypersensitivity to D‐panthenol has also been described involving one patient with contact urticaria (from a hair conditioner) and another patient with an anaphylactic reaction (from oral multi‐vitamin tablets) as well as prior contact urticaria (from a sunscreen) 9,10 …”

Section: Discussionmentioning

confidence: 99%

Calcium pantothenate is present in cosmetics and may cause allergic contact dermatitis

et al. 2020

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Calcium pantothenate (CAS no. 137‐08‐6) is the calcium salt of pantothenic acid (vitamin B5). It is used in cosmetics due to its anti‐static and hair conditioning properties. A 53‐year‐old female nurse's aide presented with intermittent facial eruptions (Figure S1). Patch tests were positive to calcium pantothenate, an ingredient of two of her products (a cleansing milk and a facial tonic). To our knowledge, no previous cases of sensitization from calcium pantothenate have been reported except for one case of systemic dermatitis from a nutritional supplement in a dexpanthenol‐sensitized patient.

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“…In a recent retrospective study of 2171 subjects with ACD who were patch tested with dexpanthenol, 26 (1.2%) had a positive reaction. 13 In another trial, 3301 subjects were enrolled and 23 (0.7%) had a positive reaction to panthenol. 14 In our report, dexpanthenol was classified as a frequent allergen due to the identification of more than 50 cases reported.…”

Section: Discussionmentioning

confidence: 99%

Allergic Contact Dermatitis Secondary to Moisturizers

et al. 2020

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Background: Moisturizers are cosmetic products used routinely to manage various skin conditions. Even though moisturizers are often thought to have minimal or no adverse reactions, allergic contact dermatitis (ACD) to these products can develop in some cases. Methods: We studied ingredients included in 3 of the most commonly used moisturizer brands, identified their presence in standard patch testing series, and evaluated their allergenic potential, categorizing the allergens as frequent or infrequent. The standard patch testing series used as reference were the Thin-layer Rapid Use Epicutaneous patch test (T.R.U.E. test), the North American Contact Dermatitis Group (NACDG) screening standard series, and the American Contact Dermatitis Society (ACDS) core allergen series. Results: Aveeno, Cetaphil, and Cerave products had a total of 12, 14, and 9 potential allergens, respectively, the majority of which were infrequent and not included in standard patch testing series. Conclusion: Being aware of the allergenic potential of commonly used moisturizers may help healthcare providers when evaluating patients with ACD. Further testing is recommended in a targeted manner when suspecting ACD with negative standard patch testing series or when ACD is refractory to treatment.

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Allergic contact dermatitis caused by dexpanthenol—Probably a frequent allergen

Cited by 25 publications

References 10 publications

Developing a cosmetic series: Results from the ESSCA network, 2009‐2018

Developing a cosmetic series: Results from the ESSCA network, 2009‐2018

Calcium pantothenate is present in cosmetics and may cause allergic contact dermatitis

Allergic Contact Dermatitis Secondary to Moisturizers

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