Allergic contact dermatitis due to 5% doxepin cream

Allergic contact dermatitis from doxepin

“…was reported to be over 20% (2). Doxepin is a tricyclic drug with antihistamine activity, and is a known skin sensitizer (2)(3)(4). If the use of this drug becomes more widespread, it may be indicated in patch-test medicament series.…”

A non‐cosmetic allergic contact dermatitis to ethylhexylglycerin

“…Ultrasonic or lubricating gels may elicit contact allergy, such as allergic contact dermatitis and more rarely contact urticaria 3 . The main reported allergens reported in ultrasonic or lubricating gels‐induced allergic contact dermatitis are preservatives such as isothiazolinones, formaldehyde releasers, phenoxyethanol, methyldibromoglutaronitrile, parabens and more rarely dyes, carbomers and propylene glycol 4–10 . Of note these gels are considered as medical devices and information about their composition is often poorly detailed or difficult to find which may raise significant issues for patients allergic to one of their constituents.…”

Contact Allergy to Topical Medicaments, Part 1: A Double-edged Sword

“…46 Doxepin is a tricyclic antidepressant with antihistamine activity and is a well-documented sensitizer. [47][48][49][50][51][52] Taylor et al 47 evaluated 97 patients with chronic dermatoses, and patch testing revealed 17 (17.5%) positive reactions to doxepin cream, 13 (76.5%) of which were positive reactions to both the commercial cream and the active ingredient. Patch testing using doxepin dilution as low as 0.5% in petrolatum is sufficient to provoke a strong (++) allergic reaction.…”