Allergic contact dermatitis from occupational exposure to dibutyl maleate

Sasseville, Denis; Lafaille, Philippe; Joncas, Valérie

doi:10.1111/j.1600-0536.2009.01539.x

Cited by 3 publications

(3 citation statements)

References 4 publications

(6 reference statements)

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“…DBM has previously been reported as a contact allergen present in glues 6,7 and in the production of gelcoats 8 . The presence of DBF and DBM in desiccant sachets and a rack covered with synthetic leather has also been reported 9 .…”

Section: Discussionmentioning

confidence: 90%

Occupational allergic contact dermatitis to dibutyl maleate and dibutyl fumarate present in a safety shoe: A reason for concern?

Siemund

Dahlin

2021

Contact Dermatitis

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Section: Discussionmentioning

confidence: 90%

Occupational allergic contact dermatitis to dibutyl maleate and dibutyl fumarate present in a safety shoe: A reason for concern?

Siemund

Dahlin

2021

Contact Dermatitis

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“…23) Of course it is important to assess the actual concentration of DBM leaching out from such membrane. On the other hand, relatively high dose (5%) of DBM was required to obtain a low-grade positive reaction in a sensitized person with patch test, 2) suggesting that a certain level of concentration is required in experimental settings. Another report revealed that DBM was detected inside furniture boxes with a disposable desiccant.…”

Section: Discussionmentioning

confidence: 99%

“…1) In 2009, a case of allergic dermatitis due to occupational exposure to DBM was reported. 2) A 47-year-old woman working as a batch mixer in a factory producing gelcoats and specialty paints developed eczematous lesions until she was withdrawn from work. Interestingly, among the North American Contact Dermatitis Group standard series, plastics, glues, adhesives as well as products in the workplace, DBM was the only chemical that gave a positive reaction in the patch test.…”

mentioning

confidence: 99%

Dibutyl Maleate and Dibutyl Fumarate Enhance Contact Sensitization to Fluorescein Isothiocyanate in Mice

Matsuoka

Kurohane

Suzuki

et al. 2016

Biological & Pharmaceutical Bulletin

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Di-n-butyl phthalate (DBP), a phthalate ester, has been shown to have an adjuvant effect on fluorescein isothiocyanate (FITC)-induced contact hypersensitivity (CHS) mouse models. Di-n-butyl maleate (DBM), widely used as a plasticizer for industrial application, has been reported to cause dermatitis in humans. DBM is a butyl alcohol ester of di-carboxylic acid that represents a part of the DBP structure, while di-nbutyl fumarate (DBF) is a trans isomer of DBM. We examined whether DBM or DBF exhibits an adjuvant effect like DBP does. When BALB/c mice were epicutaneously sensitized with FITC in the presence of DBM or DBF, the FITC-specific CHS response was enhanced, as we have observed for DBP. As to underlying mechanisms, DBM and DBF facilitated the trafficking of FITC-presenting CD11c dendritic cells (DCs) from skin to draining lymph nodes and increased the cytokine production by draining lymph nodes. In conclusion, DBM and DBF may have an effect that aggravates contact dermatitis through a skin sensitization process.Key words dibutyl maleate; dibutyl fumarate; adjuvant; contact hypersensitivity; dendritic cell trafficking; cytokine productionIn 1985, a dermatitis outbreak occurred in an envelopemaking factory where di-n-butyl maleate (DBM)-containing polyvinyl acetate glue was used. 1) In 2009, a case of allergic dermatitis due to occupational exposure to DBM was reported. 2) A 47-year-old woman working as a batch mixer in a factory producing gelcoats and specialty paints developed eczematous lesions until she was withdrawn from work. Interestingly, among the North American Contact Dermatitis Group standard series, plastics, glues, adhesives as well as products in the workplace, DBM was the only chemical that gave a positive reaction in the patch test. DBM is a colorless, clear, and oily liquid used for industrial applications. DBM consists of an alkenyl di-carboxylic acid with two butyl alcohol esters of cis configuration.Di-n-butyl fumarate (DBF) is an isomer of DBM with butyl alcohol esters of trans configuration. There has been no report on dermatitis caused by DBF. However, dimethyl fumarate (DMF) has been banned for the use in consumer products in the European Union (EU), because it caused an unprecedented large-scale dermatitis outbreak. 3) DBM and DBF have been used as plasticizers, raw materials for polymer syntheses, and preservatives for oils and fats, but the risk of their use for dermatitis development has not been established. 4) DBM represents a part of the structure of di-n-butyl phthalate (DBP), an aromatic dibutyl ester. DBP is widely used as a plasticizer for consumer products such as paints, varnishes, paper coatings and cosmetics. 5,6) Our previous studies demonstrated that DBP contributed to contact hypersensitivity (CHS) to isothiocyanate haptens as adjuvant chemicals. 7) Thus, we hypothesized that DBM might exhibit an enhancing effect through a similar mechanism as observed for DBP. We also examined whether or not DBF, an isomer of DBM, produced such an enhancing effect.In this study, we ...

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Acrylates in Contact Dermatitis

Sasseville

2012

Dermatitis

125

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Acrylates are plastic materials that are formed by the polymerization of monomers derived from acrylic or methacrylic acid. They have found numerous applications in paints, varnishes and adhesives, in the printing industry, in the medical and dental professions, and in artificial nails. Beginning in the 1950s, many reports of occupational and nonoccupational allergic contact dermatitis to (meth)acrylate monomers have been published. These molecules are strong irritants, and patch testing can induce active sensitization. When patch tested, acrylate-allergic patients often display multiple positive tests. These reactions may represent cross-reactions, or concomitant reactions due to the presence, in the products responsible for sensitization, of impurities not disclosed in material safety data sheets. (Meth)acrylates are volatile and unstable chemicals, as demonstrated by their rapid disappearance from commercially available patch test allergens when exposed to air for more than a few hours.

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Allergic contact dermatitis from occupational exposure to dibutyl maleate

Cited by 3 publications

References 4 publications

Occupational allergic contact dermatitis to dibutyl maleate and dibutyl fumarate present in a safety shoe: A reason for concern?

Occupational allergic contact dermatitis to dibutyl maleate and dibutyl fumarate present in a safety shoe: A reason for concern?

Dibutyl Maleate and Dibutyl Fumarate Enhance Contact Sensitization to Fluorescein Isothiocyanate in Mice

Acrylates in Contact Dermatitis

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