Allergic contact dermatitis to Bayo‐N‐OX‐I

Bedello, P. G.; Goitre, M; Cane, D.; Roncarolo, G.

doi:10.1111/j.1600-0536.1985.tb01141.x

Cited by 24 publications

(6 citation statements)

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“…Furthermore, OLAQ has been reported to cause allergy [36] and photoallergy in man [37][38]. Symptoms of OLAQinduced photoallergy resemble those of QUIN [31].…”

Section: Growth-promoting Properties and Toxicity Of Quinoxaline 14-mentioning

confidence: 92%

Quinoxaline 1,4-Dioxide: A Versatile Scaffold Endowed With Manifold Activities

Carta

Corona²,

Loriga

2005

CMC

137

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Since 1940s, Quinoxaline 1,4-dioxides (QdNO's) are known as potent antibacterial agents, and subtherapeutic levels have been used to promote growth and improve efficiency of feed conversion in animal feed. They have also shown a selective cytotoxicity against hypoxic cells present in solid tumours. Furthermore, recent studies have put in evidence that QdNO's are endowed with antitubercular, antiprotozoal and anticandida activities. On the other hand, several authors have reported about photoallergic and mutagenic effects of some derivatives. QdNO's may also cause the development of antibiotic-resistant bacteria and influence the horizontal transfer of virulence genes between bacteria. In this review article we report the biological properties, the mode of action and Structure Activity Relationship (SAR) studies of the QdNO derivatives. Furthermore, some cytogenetic and genotoxic effects, classical and more recent method of synthesis, the quinoxaline 1,4-dioxides, and some of their most important reactions, were also reported.

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“…Furthermore, OLAQ has been reported to cause allergy [36] and photoallergy in man [37][38]. Symptoms of OLAQinduced photoallergy resemble those of QUIN [31].…”

Section: Growth-promoting Properties and Toxicity Of Quinoxaline 14-mentioning

confidence: 92%

Quinoxaline 1,4-Dioxide: A Versatile Scaffold Endowed With Manifold Activities

Carta

Corona²,

Loriga

2005

CMC

137

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“…In the case reported, diagnosis of occupational airborne allergic contact dermatitis from olaquindox is supported by distribution of lesions, positive patch test, normal phototest and negative photopatch test, and clearance of cutaneous lesions after withdrawing olaquindox. All reports of photosensitivity or contact sensitivity to olaquindox are occupational (3–7). To our knowledge, no similar case has been described, and allergic contact dermatitis caused by olaquindox is unusual (3), photoallergic contact dermatitis being the more usual event (4, 5), also often airborne and commonly followed by a persistent light reaction (6, 7).…”

Section: Discussionmentioning

confidence: 99%

Airborne allergic contact dermatitis from olaquindox in a rabbit breeder

2002

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“…Concern has long been expressed over their use as carbadox is genotoxic and carcinogenic in experimental animals, while olaquindox is genotoxic although it has not been shown to be carcinogenic (Sykora & Vortel, 1986;Woodward, 2004). Olaquindox has been reported to cause allergic and photoallergic dermatitis in farm workers, largely in those involved with pigs, following occupational exposure (Bedello et al, 1985;Francalanci et al, 1986;Schauder, 1989;de Vries et al, 1990a,b;Hochsattel et al, 1991;Fewings & Horton, 1995;Kumar & Freeman, 1996;Schauder et al, 1996;Sanchez-Pedreno et al, 2001;Belhadjali et al, 2002;Sanchez-Perez et al, 2002). Their phototoxic potentials have also been demonstrated in animal models (de Vries et al, 1990a,b;Eberlein et al, 1992).…”

Section: Antimicrobial Drugsmentioning

confidence: 99%

Section: Antimicrobial Drugsmentioning

confidence: 99%

Veterinary pharmacovigilance. Part 4. Adverse reactions in humans to veterinary medicinal products

Woodward¹

2005

Vet Pharm & Therapeutics

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Although seemingly rare, adverse reactions to veterinary products do occur. These may arise from inadvertent exposure during use or as a result of occupational accidents. They are often mild in nature and include adverse effects such as minor skin reactions. However, more serious reactions may occur, and they are not restricted to the effects of the veterinary medicines themselves. For example, high-pressure injection injuries may occur as a result of accidents occurring during animal vaccination operations. This paper reviews some of these events, mentions where appropriate the regulatory actions taken, and describes some of the measures used to minimise such effects in the future, and serves to bring the issues discussed here to the attention of pharmacologists, pharmacoepidemiologists and others who train those who use veterinary medicinal products.

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Allergic contact dermatitis to Bayo‐N‐OX‐I

Cited by 24 publications

References 0 publications

Quinoxaline 1,4-Dioxide: A Versatile Scaffold Endowed With Manifold Activities

Quinoxaline 1,4-Dioxide: A Versatile Scaffold Endowed With Manifold Activities

Airborne allergic contact dermatitis from olaquindox in a rabbit breeder

Veterinary pharmacovigilance. Part 4. Adverse reactions in humans to veterinary medicinal products

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