Allergic contact dermatitis to zinc pyrithione

Zinc pyrithione (Zinc Omadine®) allergy

“…In only one of our patients was the Zinc Omadine reaction interpreted with certainty as being of present relevance. It is noteworthy that a concomitant nickel allergy was found in 2 patients, which was also found in 3 of the published patients (1,3). We are unable to explain this coincidence, cross-sensitivity being unlikely.…”

“…It is known under the proprietary names Zinc Omadine®, Vancide ZP® and Zincon® (1). Despite widespread use, only 5 case reports on contact allergy (1)(2)(3)(4)…”

Allergic contact dermatitis from sodium pyrithione in metalworking fluid

“…Pyrithione is a more frequent cosmetic sensitizer. Zinc pyrithione, CAS 13463‐41‐7, is largely used in anti‐dandruff preparations (9–14). Since the hapten is the pyrithione moiety, either zinc or sodium pyrithione can be used for patch testing, pet.…”

Targeted Delivery of Zinc Pyrithione to Skin Epithelia

“…In animal sensitization studies, which involve initial contact and subsequent challenge to simulate the elicitation and induction phases of response [ 154 ], ZnPT was deemed not to have any sensitization potential [ 12 ]. Unsurprisingly, for a drug so widely used since it was first approved there have been isolated case reports of human sensitivity to ZnPT [ 155 , 156 , 157 , 158 , 159 ]. The occurrence of sensitivity does however remain very low, with a positive patch test rate ranging from 0.002% (3 individuals out of 1652) [ 155 ] to 1.2% (2 individuals out of 171) [ 156 ].…”