Allergic contact response to vitamin A acid

Abstract

Three patients treated daily with vitamin A acid cream experienced after one week, seven weeks and 14 weeks respectively sudden redness and itching at the treated sites. Patch testing with the cream (containing 0.05% vitamin A acid) and with vitamin A acid 0.05% in absolute alcohol produced strongly positive reactions in the patients but only slight erythema in some of the controls. Since patch testing with vitamin A acid 0.005% in absolute alcohol elicited no response in controls but positive reactions in the three patients, it is probable that these latter reactions were due to contact allergy. Histologically the test reaction showed intact epidermis and dense dermal infiltration by mononuclear cells, and thus resembled a response of the tuberculin type.

Periorbital allergic contact dermatitis resulting from topical retinoic acid use

“…Tomb and colleagues describe a single case of contact allergy to tretinoin in a 34‐year‐old man, and patch testing was positive to tretinoin and isotretinoin . Earlier case reports of allergic contact dermatitis to retinoic acid have also been described . To our knowledge, there have been no reported cases of allergic contact dermatitis after the ocular use of retinoic acid.…”

Photosensitization eczema with positive erythrosine test

“…The dermatitis was undoubtedly provoked by retinoic acid, whereas the positive patch tests with both preparations may have been partly irritant. Although five controls were negative to both prepara-tions, other authors have found that a 0.05 % concentration of retinoic acid caused slight erythema in some controls (Lindgren et al 1976). Allergic contact dermatitis (ACD) to a.-methylene-y-butyrolactone derivatives (Fig.…”

“…During this period, she presented with intermittent erythema three times, but it always disappeared within 48 h without any other manifestation. Sensitization to retinoic acid has been described several times (Nordqvist & Mehr 1975, Jordan et al 1975, Lindgren et al 1976). In Poland this preparation has been only recently introduced and applied to a small number of patients.…”

Allergic contact dermatitis caused by topical antiacne drugs

“…Efficacy of tretinoin used as short contact therapy is superimposable on that of tretinoin used according to standard modality [2,3]. Things to be followed for prevention of RD are: to begin the treatment with lower concentrations of retinoid, when possible; to begin the treatment applying the retinoid daily for a few hours and slowly increasing the application time until skin tolerance is acquired (hardening or accommodation phenomenon) [5] [6] published the first two cases of ACD caused by all-trans-retinoic acid, less than 20 cases have been published [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]. Most of the cases were caused by tretinoin (TABLE 2) [6-10, 12,13,[15][16][17][18][19]21].…”