Photosensitization eczema with positive erythrosine test

Castelain, P Y; Piriou, Alain

doi:10.1111/j.1600-0536.1978.tb04570.x

Cited by 6 publications

(6 citation statements)

References 1 publication

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“…Accordingly, some of the mechanisms of iodine allergy are classified as photo-allergy. Castelain and Piriou reported a case of photosensitization eczema with a positive erythrosine test (Castelain and Piriou, 1978).…”

Section: Discussionmentioning

confidence: 99%

Studies on Experimental Iodine Allergy: 2. Iodinated Protein Antigens and Their Generation From Inorganic and Organic Iodine-Containing Chemicals

et al. 2004

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-We hypothesize that iodine allergy is an immune response to iodinated autologous proteins generated in vivo from iodine-containing organic and inorganic chemicals. In this report, effects of protein iodination on elicitogenic activity in guinea pig iodine allergy model and iodinated protein antigen generation in vitro from iodine-containing chemicals were investigated.Active cutaneous anaphylaxis (ACA) and delayed-type hypersensitivity (DTH) tests were performed in guinea pigs immunized with iodine. The amount of iodine (I 2 ) reacted to proteins for giving them an eliciting activity of ACA was ≥0.15 µmol for 1 mg of albumin. DTH reactions were provoked by intradermal injection of 10 6 PECs reacted with ≥0.075 µmol of I 2 . I 2 was generated from a potassium iodide (KI) solution or iodinated contrast media by UV light irradiation. X-ray irradiation of KI and iodinated contrast media in the presence of protein resulted in the generation of iodinated protein antigens. The generation of iodinated protein antigens was inhibited in the presence of reducing agents. Therefore, it is noteworthy that iodine allergy of the present hypothesis is dependent on reactive oxygens. By presenting these ex vivo and in vitro data, we discuss the possibilities for the generation of iodinated protein antigens in vivo.

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Section: Discussionmentioning

confidence: 99%

Studies on Experimental Iodine Allergy: 2. Iodinated Protein Antigens and Their Generation From Inorganic and Organic Iodine-Containing Chemicals

et al. 2004

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“…In the case of a premature infant, phototoxic epidermolysis developed after intestinal fluorescein angiography, followed by UVA exposure (6). In the case of an adult female, a positive cutaneous patch test identified erythrosine (tetraiodofluorescein) as the possible cause of dermatitis (7). Photopatch tests, however, were not done.…”

Section: Discussionmentioning

confidence: 99%

“…Side-effects after parenteral application may occur as mild systemic reactions or, rarely, as anaphylactic reactions (1)(2)(3)(4)(5). Photosensitizing effects have been observed only sporadically (6,7). Here, we report a case of photoallergic reaction to fluorescein.…”

mentioning

confidence: 89%

Photoallergic reaction to fluorescein

et al. 1990

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A photoallergic reaction to fluorescein was demonstrated in a male diabetic by photopatch and photoprovocation tests. Sensitization was acquired by tonometries using a fluorescein-containing local anesthetic, preceding fluorescein angiography for diagnosis of diabetic retinopathy. Histopathological examination of skin lesions induced in both photopatch and photoprovocation tests confirmed the diagnosis of photoallergic reaction to fluorescein.

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“…115 Patients with the classic aspirin triad reaction (asthma, urticaria, and rhinitis) or anaphylactoid reactions may also develop similar reactions from dyes other than tartrazine, including amaranth, 116 -118 erythrosine, 118 Gastrointestinal intolerance, with abdominal pain, vomiting, and indigestion, has been associated with sunset yellow; in one case, eosinophilia and hives were also present. 123,124 Other dermatologic reactions, including photosensitivity, erythroderma, and desquamation, 125 have been attributed to erythrosine, an iodine-containing dye. By mandate, erythrosine has been removed from topical products and is being voluntarily removed from many oral drug products because of concerns about carcinogenicity.…”

Section: Coloring Agentsmentioning

confidence: 99%

“Inactive” Ingredients in Pharmaceutical Products: Update (Subject Review)

1997

Pediatrics

141

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ABSTRACT. Because of an increasing number of reports of adverse reactions associated with pharmaceutical excipients, in 1985 the Committee on Drugs issued a position statement 1 recommending that the Food and Drug Administration mandate labeling of over-thecounter and prescription formulations to include a qualitative list of inactive ingredients. However, labeling of inactive ingredients remains voluntary. Adverse reactions continue to be reported, although some are no longer considered clinically significant, and other new reactions have emerged. The original statement, therefore, has been updated and its information expanded.ABBREVIATIONS. FDA, Food and Drug Administration; MDIs, metered-dose inhalers Pharmaceutical products often contain agents that have a variety of purposes, including improvement of the appearance, bioavailability, stability, and palatability of the product. Excipients (substances added to confer a suitable consistency or form to a drug, such as the vehicle, preservatives, or stabilizers) frequently make up the majority of the mass or volume of oral and parenteral drug products. These pharmaceutical adjuvants are usually considered to be inert and do not add to or affect the intended action of the therapeutically active ingredients.Some 773 chemical agents have been approved by the Food and Drug Administration (FDA) for use as inactive ingredients in drug products.2 Inasmuch as these compounds are classified as "inactive," no regulatory statutes require listing on product labeling. Pharmacopeial guidelines, enforceable under the Food, Drug, and Cosmetic Act, do require labeling of inactive ingredients for topical, ophthalmic, and parenteral preparations; orally administered products are currently exempt. Because of pressure from professional and consumer organizations asking the FDA to require complete disclosure of all ingredients, voluntary labeling was adopted by the two major pharmaceutical industry trade associations. These voluntary guidelines contain an exemption for "trade secret" components and do not require complete disclosure of all fragrance and flavoring ingredients.Current problems encountered with "inactive" ingredients include benzalkonium chloride-induced bronchospasm from antiasthmatic drugs, aspartameinduced headache and seizures, saccharin-induced cross-sensitivity reactions in children with sulfonamide allergy, benzyl alcohol toxicity in neonates receiving high-dose continuous infusion with preserved medications, dye-related cross-reactions in children with aspirin intolerance, lactose-induced diarrhea, and propylene glycol-induced hyperosmolality and lactic acidosis. Although many other excipients have been implicated in causing adverse reactions, these are the most significant in the pediatric population. ANTIASTHMATIC MEDICATIONSIt is readily appreciated that some percentage of asthmatic children will develop a "paradoxical" bronchospasm after they inhale their medication. Because many of these reactions were attributed to sulfite, which had been highly publicized ...

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Photosensitization eczema with positive erythrosine test

Cited by 6 publications

References 1 publication

Studies on Experimental Iodine Allergy: 2. Iodinated Protein Antigens and Their Generation From Inorganic and Organic Iodine-Containing Chemicals

Studies on Experimental Iodine Allergy: 2. Iodinated Protein Antigens and Their Generation From Inorganic and Organic Iodine-Containing Chemicals

Photoallergic reaction to fluorescein

“Inactive” Ingredients in Pharmaceutical Products: Update (Subject Review)

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