Studies on Experimental Iodine Allergy: 2. Iodinated Protein Antigens and Their Generation From Inorganic and Organic Iodine-Containing Chemicals

Shionoya, Hiroshi; Sugihara, Yoshiki; Sagami, Fumio; Mikami, Takashi; Katayama, Kouichi

doi:10.2131/jts.29.137

Cited by 8 publications

(8 citation statements)

References 17 publications

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“…Dermatologic side effects reported are acneiform eruption, iodermas (erythematous, vesicular, bullous, urticarial, nodular or vegetating lesions on the face, shoul-der, and extremities) (14), and worsening of dermatitis herpetiforme (15). Rare side effects are periarteritis nodosa, pustular psoriasis (16), and granulomatous vasculitis (17); their pathophysiology is unclear (18,19). In particular, the mechanism of the reaction observed in our case is unknown, and it is possible that the acute mucositis may be the result of a direct reaction to the high dose of iodine rather than to hypersensitivity.…”

Section: Discussionmentioning

confidence: 99%

Acute Ioderma: an Uncommon Serious Adverse Event Associated with Saturated Solution of Potassium Iodide Treatment

Rivero

Cochran

Celi

2018

AACE Clinical Case Reports

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Objective:The objective of this report is to raise awareness of a case with acute life-threatening ioderma, an uncommon adverse event of saturated solution of potassium iodide (SSKI) therapy. Although extremely rare, physicians should consider the potential for ioderma development as a dangerous but treatable side effect of SSKI therapy.Methods: We present a case report of an uncommon serious adverse event associated with SSKI therapy.Results: A 67-year-old woman with mutlinodular goiter and subclinical hyperthyroidism was prescribed SSKI in preparation for total thyroidectomy. Unfortunately, the patient disregarded the instructions and took the equivalent of three doses at once without any fluid. Six hours later, she developed a reaction characterized by angioedema and hemorrhagic papulo-vesicular rash involving the oral mucosa and her extremities, sparing the trunk. The patient was hospitalized and treated with corticosteroids with prompt resolution of her symptoms. Subsequently, she underwent successful total thyroidectomy. Conclusion: SSKI is considered a safe and effective drug rarely associated with dermatologic side effects. Ioderma is an idiopathic reaction characterized by acneiform, vesicular pustular, hemorrhagic, or urticarial lesions. Other systemic side effects of SSKI include urticaria, fever, eosinophilia, jaundice, pruritus, angioedema, and bronchospasm. High-dose steroid is the therapy of choice, with prompt regression of the symptomatology. Physicians should consider this rare, severe, but treatable condition when prescribing SSKI. (AACE Clinical Case Rep. 2018;4:e127-e130) Abbreviation: SSKI = saturated solution of potassium iodide CASE REPORTA 67-year-old female with a 10-year history of hyperthyroidism secondary to toxic multinodular goiter present-e128 SSKI-Induced Dermatopathy, AACE Clinical Case Rep. 2018;4(No. 2)

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Section: Discussionmentioning

confidence: 99%

Acute Ioderma: an Uncommon Serious Adverse Event Associated with Saturated Solution of Potassium Iodide Treatment

Rivero

Cochran

Celi

2018

AACE Clinical Case Reports

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“…In addition, while we know of no previous study evaluating patient’s age in association with adverse reactions, one previous study demonstrated that older patients may have stronger reactions to histamine [25]. Finally, the dose of administered iodine has been shown to be associated with iodine allergy [26] ,while chemotoxic reactions are known to be dependent on dose and infusion rate [13]. …”

Section: Discussionmentioning

confidence: 99%

Risk factors for adverse reactions from contrast agents for computed tomography

Kobayashi

Takahashi

Ueda

et al. 2013

BMC Med Inform Decis Mak

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BackgroundSymptoms of an adverse reaction to contrast agents for computed tomography are diverse ranging, and sometimes serious. The goal of this study is to create a scoring rule to predict adverse reactions to contrast agents used in computed tomography.MethodsThis was a retrospective cohort study of all adult patients undergoing contrast enhanced CT scan for 7 years. The subjects were randomly divided into either a derivation or validation group. Baseline data and clinically relevant factors were collected from the electronic chart. Primary outcome was any acute adverse reactions to contrast media, observed for during 24 hours after administration. All potential candidate predictors were included in a forward stepwise logistic regression model. Prediction scores were assigned based on β coefficient. A receiver operating characteristic (ROC) curve was drawn, and the area under the curve (AUC) and incidence of acute adverse reactions at each point were obtained. The same process was performed in the validation group.Results36,472 patients underwent enhanced CT imaging: 20,000 patients in the derivation group and 16,472 in the validation group. A total of 409 (2.0%, 95% CI:1.9-2.3) and 347 (2.1%, 95% CI:1.9-2.3) acute adverse reactions were seen in the derivation and validation groups. Logistic regression analysis revealed that prior adverse reaction to contrast agents, urticaria, an allergic history to drugs other than contrast agents, contrast agent concentration >70%, age <50 years, and total contrast agent dose >65 g were significant predictors of an acute adverse reaction. AUC was 0.70 (95% CI:0.67-0.73) and 0.67 (95% CI:0.64-0.70) in the derivation and validation groups.ConclusionsWe suggest a prediction model consisting of six predictors for acute adverse reactions to contrast agents used in CT.

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“…22 Generation of molecular iodine from potassium iodide solutions by UV light irradiation. A 4 mL aliquot of 1 mM potassium iodide in 0.1 M phosphate buffer (pH 6.5 or 7.2) was added to 1 mL of 1% soluble starch and was irradiated by UV light in a glass dish of 4-cm diameter with magnetic stirring[113].…”

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confidence: 99%

“…Shionoya et al[113] studied the effects of UV light on the generation of molecular iodine from iodinated CM. Shionoya et al[113] studied the effects of UV light on the generation of molecular iodine from iodinated CM.…”

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confidence: 99%