Allergic contact stomatitis due to therapeutic propolis

Fernández, S; Luaces, Eva Lasa; Madoz, Susana Echechipía; Alemán, Esozia Arroabarren; Apiñániz, Marta Anda; Purroy, Ana Isabel Tabar

doi:10.1111/j.0105-1873.2004.00341h.x

Cited by 24 publications

(12 citation statements)

References 6 publications

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“…Propolis' sensitizing properties explain the numerous reports of allergic contact dermatitis (1,2,7,(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21). Propolis is known as an occupational contact allergen mainly in beekeepers, but also in musicians and manufacturers of stringed musical instruments (1,10,14,(16)(17)(18)(19).…”

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confidence: 99%

“…Propolis is known as an occupational contact allergen mainly in beekeepers, but also in musicians and manufacturers of stringed musical instruments (1,10,14,(16)(17)(18)(19). However, most cases of propolis allergy are not occupational (1,7,9,10,12,13,20,21). This compound is widely used in folk medicine and in the biocosmetic industry for its antiseptic, antimycotic, bacteriostatic, astringent, choleric, spasmolytic, anti-inflammatory and anaesthetic properties.…”

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confidence: 99%

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Sensitization to propolis in 1255 children undergoing patch testing

et al. 2004

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To investigate the frequency and the features of contact sensitization to propolis in children, we patch tested 1255 consecutive children suspected of allergic contact dermatitis with propolis 20% petrolatum over an 8-year period (1995-2002). Positive responses were observed in 5.9% of patch-tested subjects, with a significantly higher frequency in boys than in girls. The dermatitis was localized mainly on the face, hands and limbs. A significant linear increase in the annual frequency of propolis allergy was noted. Confirming literature data, a significant association with balsam of Peru sensitivity was present in children reacting to propolis, linked to the presence of common constituents in the 2 substances. In conclusion, based on our data, we suggest that propolis should not be used in topical products for children because of its high sensitization rate at the paediatric age.

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confidence: 99%

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confidence: 99%

Sensitization to propolis in 1255 children undergoing patch testing

et al. 2004

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“…8Y11 Chewing propolis has been reported to cause allergic stomatitis, labial and oral swelling, dyspnea, and labial and perioral eczema. 12,13 Propolis, balsam of Peru, and colophony share constituents leading to cross-sensitization among these allergens. 14 In a large retrospective study of patients from the British Contact Dermatology Society database, 70% of patients who reacted to propolis reacted to at least 1 other of these 3.…”

Section: Discussionmentioning

confidence: 99%

Fixed Drug Eruption to Ingested Propolis

Ramien¹,

Pratt²

2012

Dermatitis

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Fixed drug eruptions (FDEs) are a unique type of drug allergy in which skin lesions recur in the same location after each ingestion of the offending agent. More than 100 drugs have been implicated in causing FDEs. More recently, herbal medications and food additives have been implicated. Propolis is an important contact allergen, but has not previously been reported to cause FDE. We present the case of a patient with a 1-year history of a recurrent lesion on the shaft of his penis. He tested strongly positive to propolis and had been using a herbal supplement. A trial off this supplement was initiated, and his penile lesion cleared. The patient then rechallenged himself with his powder and developed the same reaction, biopsy-proven to be consistent with FDE. This case illustrates the utility of systemic (rechallenge) and topical (patch-testing) testing to identify the causative agent. It is interesting to note that our patient developed a reaction at the site of the patch test for propolis itself, rather than at the former reaction site. Our patient also illustrates the necessity of considering new causes for FDE when typical lesions are present.

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“…In Spain, Fernández et al [304] have reported three cases in beekeepers of occupational contact sensitization to propolis, with varied features, and considered that propolis a direct and an airborne contact allergen. Allergic contact stomatitis in two cases caused by propolis administrated for therapeutic purposes, were signaled by the same group of research Fernández et al [305] and Cabanillas et al [306] Fernández et al [305] declared that the compounds 3-methyl-2-butenyl caffeate, phenylethyl caffeate, benzyl salicylate and benzyl cinnamate found in propolis composition, are main causes of this allergy. In Italy, Pasolini et al [307] described an allergic contact cheilitis with chronicity induced by repeated contact with propolis contained in homemade honey.…”

Section: Propolis Allergymentioning

confidence: 96%

“…Moreover, it was reported that propolis is a strong sensitizer and well-known in apiarists as an occupational allergic eczematous contact dermatitis, [310] also declaring that propolis is contraindicated in patients with an allergic predisposition, being a potent allergic agent. Fernández et al [305] and Menniti-Ippolito et al [310] affirmed that the allergenic action seems to be due to caffeic acids derivates. Bellegrandi et al [311] in a case report, reported an allergic contact dermatitis (cheilitis and stomatitis) in HIV-infected patients provoked by propolis.…”

Section: Propolis Allergymentioning

confidence: 98%

Insight on Propolis from Mediterranean Countries: Chemical Composition, Biological Activities and Application Fields

El-Guendouz

Lyoussi

Miguel

2019

Chemistry & Biodiversity

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This review updates the information upon the chemical composition of propolis from all Mediterranean countries as well as their biological properties and applications. The non‐volatile fraction of propolis was characterized by the presence of phenolic acids and their esters and flavonoids. Nevertheless, in some countries, diterpenes were also present: Sicily (Italy), Croatia, Malta, Creta (Greece), Turkey, Cyprus, Egypt, Libya, Algeria and Morocco. The volatile fraction of propolis was characterized by the presence of benzoic acid and its esters, mono‐ and sesquiterpenes, being the oxygenated sesquiterpene β‐eudesmol characteristic of poplar propolis, whereas the hydrocarbon monoterpene α‐pinene has been related with the presence of conifers. Regardless the chemical composition, there are common biological properties attributed to propolis. Owing to these attributes, propolis has been target of study for applications in diverse areas, such as food, medicine and livestock.

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Allergic contact stomatitis due to therapeutic propolis

Cited by 24 publications

References 6 publications

Sensitization to propolis in 1255 children undergoing patch testing

Sensitization to propolis in 1255 children undergoing patch testing

Fixed Drug Eruption to Ingested Propolis

Insight on Propolis from Mediterranean Countries: Chemical Composition, Biological Activities and Application Fields

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