Allergic eye disease

Patel, Darshak S; Arunakirinathan, Meena; Stuart, Alastair; Angunawela, Romesh

doi:10.1136/bmj.j4706

Cited by 35 publications

(26 citation statements)

References 35 publications

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“…Herpes simplex virus type 1 (HSV-1) is a common cause of neurotropic keratitis and remains a leading cause of infectious corneal blindness (Sacchetti and Lambiase, 2014; Farooq and Shukla, 2012). The incidence of ocular allergy exceeds twenty percent of the population with varying degrees of neurogenic ocular surface discomfort that can severely diminish quality of life (Craig et al, 2017; Patel et al, 2017; Saban et al, 2013). Finally, GVHD is the greatest cause of non-relapse morbidity following hematopoietic stem cell transplantation (HSCT) used to treat life-threatening malignancies and immunologic diseases (MacDonald et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Complement and CD4+ T cells drive context-specific corneal sensory neuropathy

Royer

Echegaray-Mendez

Lin

et al. 2019

eLife

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Whether complement dysregulation directly contributes to the pathogenesis of peripheral nervous system diseases, including sensory neuropathies, is unclear. We addressed this important question in a mouse model of ocular HSV-1 infection, where sensory nerve damage is a common clinical problem. Through genetic and pharmacologic targeting, we uncovered a central role for C3 in sensory nerve damage at the morphological and functional levels. Interestingly, CD4 T cells were central in facilitating this complement-mediated damage. This same C3/CD4 T cell axis triggered corneal sensory nerve damage in a mouse model of ocular graft-versus-host disease (GVHD). However, this was not the case in a T-dependent allergic eye disease (AED) model, suggesting that this inflammatory neuroimmune pathology is specific to certain disease etiologies. Collectively, these findings uncover a central role for complement in CD4 T cell-dependent corneal nerve damage in multiple disease settings and indicate the possibility for complement-targeted therapeutics to mitigate sensory neuropathies.

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Section: Introductionmentioning

confidence: 99%

Complement and CD4+ T cells drive context-specific corneal sensory neuropathy

Royer

Echegaray-Mendez

Lin

et al. 2019

eLife

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“…Allergic eye disease (AED) is widely prevalent in the general population today, with numbers ranging from 10% to 20% in the adult population [1]. According to the World Health Organization (WHO), allergic diseases lead to a significant drop in quality of life and were a burden on the public health system [2].…”

Section: Introductionmentioning

confidence: 99%

Unique corneal tomography features of allergic eye disease identified by OCT imaging and artificial intelligence

Matalia

Pisharody

et al. 2020

Journal of Biophotonics

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The purpose of this study was to assess unique corneal tomographic parameters of allergic eye disease (AED) using optical coherence tomography (OCT) and artificial intelligence (AI). A total of 57 eyes diagnosed with AED were included. The curvature and aberrations of the airepithelium (A-E) and epithelium-Bowman's layer (E-B) interfaces were calculated. Random forest AI models were built combing this data with the parameters of healthy, forme fruste keratoconus (FFKC) and KC eyes. The AI models were cross-validated with 3-fold random sampling. Each model was limited to 10 trees. The AI model incorporating both A-E and E-B parameters provided the best classification of AED eyes (area under the curve = 0.958, sensitivity = 80.7%, specificity = 98.5%, precision = 88.2%). Further, the E-B interface parameters provided the highest information gain in the AI model. A few AED eyes (n = 9) had tomography parameters similar to FFKC and KC eyes and may be at risk of progression to KC.

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“… 1 The symptoms of AC include itching, eyelid swelling, chemosis, tearing, and redness, which negatively impact the quality of daily life. 2 , 3 AC is primarily caused by both type I and type IV hypersensitivity and characterized by aberrant T helper type 2 (Th2) inflammatory responses, which involve an intricate interplay between various cells including dendritic cells (DCs), T cells, B cells, eosinophils, basophils, and mast cells 4 .…”

mentioning

confidence: 99%

The Potential Inhibitory Effects of miR-19b on Ocular Inflammation are Mediated Upstream of the JAK/STAT Pathway in a Murine Model of Allergic Conjunctivitis

Guo

Liu

Peng

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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Citation: Guo C, Liu J, Hao P, et al. The potential inhibitory effects of miR-19b on ocular inflammation are mediated upstream of the JAK/STAT pathway in a murine model of allergic conjunctivitis. Invest Ophthalmol Vis Sci. 2020;61(3):8. https://doi.org/10.1167/iovs.61.3.8 PURPOSE.Thymic stromal lymphopoietin (TSLP) is a pro-allergic cytokine that initiates allergic inflammatory reaction between epithelial and dendritic cells (DCs). miR-19b was reported to suppress TSLP expression. The present study aimed to examine miR-19b expression, regulation, and function in allergic conjunctivitis (AC). METHODS.A murine model of experimental AC was induced in BALB/c mice by short ragweed pollen. The serum, eye balls, conjunctiva, and cervical lymph nodes (CLN) were used for the study. Gene expression was determined by RT-PCR, whereas protein production and activation were evaluated by immunostaining, ELISA, and Western blotting. RESULTS.In the murine AC model, miR-19b was aberrantly downregulated, whereas the levels of TSLP and p-STAT3, as well as the number of CD11c+ pSTAT3+ DCs were increased. Moreover, Th2 inflammatory cytokine expression was significantly increased. These severe phenotypes could be counteracted by either applying exogenous miR-19b mimic microRNAs or the JAK/STAT inhibitor CYT387. Moreover, overexpression of miR-19b repressed p-STAT3 expression and the number of CD11c+ cells in AC eye and CLN tissues.CONCLUSIONS. These findings suggested that miR-19b reduced ocular surface inflammation by inhibiting Stat3 signaling via TSLP downregulation in a murine AC model. Moreover, the present study further demonstrated the clinical potential of applying miR-19b and anti-JAK/STAT therapies in the treatment of AC.

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Allergic eye disease

Cited by 35 publications

References 35 publications

Complement and CD4+ T cells drive context-specific corneal sensory neuropathy

Complement and CD4+ T cells drive context-specific corneal sensory neuropathy

Unique corneal tomography features of allergic eye disease identified by OCT imaging and artificial intelligence

The Potential Inhibitory Effects of miR-19b on Ocular Inflammation are Mediated Upstream of the JAK/STAT Pathway in a Murine Model of Allergic Conjunctivitis

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