Allergic fungal rhinosinusitis

Silva, Marianella Paz; Baroody, Fuad M.

doi:10.1016/j.anai.2012.12.021

Cited by 7 publications

(6 citation statements)

References 20 publications

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“…Eosinophilic mucin is not present in all forms of CRSwNP 1709 . Dematiaceous fungi and Aspergillus are commonly identified in mucin from AFRS, but fungi are diverse and vary based on geographical region 622,1692,1696,1709,1710 . In 1 Australian study, correlation between fungal species in mucin and systemic fungal allergy was weak 633 .…”

Section: Chronic Rhinosinusitis With Nasal Polyps (Crswnp)mentioning

confidence: 97%

International consensus statement on allergy and rhinology: rhinosinusitis 2021

Orlandi

Kingdom

Smith

et al. 2021

Int Forum Allergy Rhinol

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525

479

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I. Executive Summary Background The 5 years since the publication of the first International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed foundational progress in our understanding and treatment of rhinologic disease. These advances are reflected within the more than 40 new topics covered within the ICAR‐RS‐2021 as well as updates to the original 140 topics. This executive summary consolidates the evidence‐based findings of the document. Methods ICAR‐RS presents over 180 topics in the forms of evidence‐based reviews with recommendations (EBRRs), evidence‐based reviews, and literature reviews. The highest grade structured recommendations of the EBRR sections are summarized in this executive summary. Results ICAR‐RS‐2021 covers 22 topics regarding the medical management of RS, which are grade A/B and are presented in the executive summary. Additionally, 4 topics regarding the surgical management of RS are grade A/B and are presented in the executive summary. Finally, a comprehensive evidence‐based management algorithm is provided. Conclusion This ICAR‐RS‐2021 executive summary provides a compilation of the evidence‐based recommendations for medical and surgical treatment of the most common forms of RS.

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Section: Chronic Rhinosinusitis With Nasal Polyps (Crswnp)mentioning

confidence: 97%

International consensus statement on allergy and rhinology: rhinosinusitis 2021

Orlandi

Kingdom

Smith

et al. 2021

Int Forum Allergy Rhinol

Self Cite

525

479

View full text Add to dashboard Cite

show abstract

“…1077,1083 Dematiaceous fungi and Aspergillus are commonly identified, but fungi are diverse and vary based on geographical region. 1073,1075,1076,1081,1083,1084 Interestingly, correlation between fungal species in mucin and systemic fungal allergy was poor in 1 Australian study. 370 Clinically, AFRS tends to be a more severe form of CRSwNP.…”

Section: Viiig Crswnp and Afrs: Differences In Pathophysiologymentioning

confidence: 99%

“…359,1078 This has stirred debate regarding AFRS pathophysiology. 370,1072,1076 CRSwNP, including AFRS, often involves a Th2-predominant immune response with eosinophilic inflammation. 1071,1079,1080 Theoretically, the primary stimulus in AFRS is a Type I IgE-mediated hypersensitivity to ubiquitous fungal allergens.…”

Section: Viiig Crswnp and Afrs: Differences In Pathophysiologymentioning

confidence: 99%

“…1073,1074 In AFRS, inhaled fungal spores are believed to trigger an escalating immunologic reaction of the sinonasal cavities. 1075,1076 The 1994 BentKuhn AFRS diagnostic criteria include: type I hypersensitivity, nasal polyposis, characteristic CT findings, eosinophilic mucus without fungal invasion, and positive fungal stain. 358,1077 Aside from NPs, these criteria collectively help to differentiate AFRS from other forms of CRSwNP.…”

Section: Viiig Crswnp and Afrs: Differences In Pathophysiologymentioning

confidence: 99%

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International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

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558

888

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Background:The body of knowledge regarding rhinosinusitis (RS) continues to expand, with rapid growth in number of publications, yet substantial variability in the quality of those presentations. In an effort to both consolidate and critically appraise this information, rhinologic experts from around the world have produced the International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR:RS). Methods:Evidence-based reviews with recommendations (EBRRs) were developed for scores of topics, using previously reported methodology. Where existing evidence was insufficient for an EBRR, an evidence-based review (EBR) was produced. The sections were then synthesized and the entire manuscript was then reviewed by all authors for consensus. Results:The resulting ICAR:RS document addresses multiple topics in RS, including acute RS (ARS), chronic RS (CRS) with and without nasal polyps (CRSwNP and CRSsNP), recurrent acute RS (RARS), acute exacerbation of CRS (AE-CRS), and pediatric RS. Conclusion:As a critical review of the RS literature, ICAR:RS provides a thorough review of pathophysiology and evidence-based recommendations for medical and surgical treatment. It also demonstrates the significant gaps in our understanding of the pathophysiology and optimal management of RS. Too o en the foundation upon which these recommendations are based is comprised of lowerlevel evidence. It is our hope that this summary of the evidence in RS will point out where additional research efforts may be directed. C 2016 ARS-AAOA, LLC. Key Words:rhinosinusitis; chronic rhinosinusitis; acute rhinosinusitis; recurrent acute rhinosinusitis; evidence-based medicine; systematic review; endoscopic sinus surgery List of Abbreviations Used

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“…Bent and Kuhn's criteria were followed, except for unilaterality, due to various new publications that have discussed the presence of bilateral manifestation of AFRS [12][13][14]. We excluded patients aged ≥19 years.…”

Section: Methodsmentioning

confidence: 99%

Pediatric Allergic Fungal Rhinosinusitis: Does Age Make a Difference?

Alamoudi¹,

Alzabidi²,

Bukhari³

et al. 2022

Cureus

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BackgroundAllergic fungal rhinosinusitis (AFRS) is a hypersensitive response to fungi within the sinus cavity. Children represent a challenging group of patients with sinonasal disorders, as their sinus anatomy is not fully developed. This study aimed to determine the various clinical manifestations and management outcomes in children with AFRS. MethodsA retrospective chart review of children who underwent sinus surgery for AFRS at a tertiary healthcare center between 2005 and 2021 was performed. Demographics, clinical manifestations, radiological and laboratory results, treatment regimens, complications, and recurrence rates were collected. Subanalysis was performed based on age at first surgery: group A (<13 years) and group B (≥13 years). ResultsOverall, 35 children underwent sinus surgery for AFRS during the study period. The mean patient age at the time of surgery was 14 years. Bilaterality was present in 15/35 (42.9%) patients and anosmia in 12/35 (34.3%). Polyps on examination were present in 31/35 (88.6%) patients and proptosis in 8/35 (22.9%). Subanalysis revealed that group A showed less bilateral disease (11.4%) than group B (31.4%) and a lower Lund-Mackay score (median=11.50 and 17, respectively, p=0.002). ConclusionAge at surgery did not have an impact on the outcome. A high index of suspicion should be exercised when dealing with children with sinonasal symptoms that do not respond to routine treatment and should be investigated for chronic sinusitis.

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Allergic fungal rhinosinusitis

Cited by 7 publications

References 20 publications

International consensus statement on allergy and rhinology: rhinosinusitis 2021

International consensus statement on allergy and rhinology: rhinosinusitis 2021

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Pediatric Allergic Fungal Rhinosinusitis: Does Age Make a Difference?

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