Allergic profiles of mothers and fathers in the Japan Environment and Children’s Study (JECS): a nationwide birth cohort study

Yamamoto‐Hanada, Kiwako; Yang, Limin; Ishitsuka, Kazue; Ayabe, Tadayuki; Mezawa, Hidetoshi; Konishi, Mizuho; Shoda, Tetsuo; Matsumoto, Kenji; Saito, Hirohisa; Ohya, Yukihiro

doi:10.1186/s40413-017-0157-0

Cited by 42 publications

(27 citation statements)

References 21 publications

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“…The results of the ImmunoCAP system were given as exact values in UA/mL. Values of 0.35 UA/mL or higher were taken as a sign of sensitization (Yamamoto-Hanada et al, 2017 ).…”

Section: Methodsmentioning

confidence: 99%

16S Metagenomics Reveals Dysbiosis of Nasal Core Microbiota in Children With Chronic Nasal Inflammation: Role of Adenoid Hypertrophy and Allergic Rhinitis

Migliori

Zicari

Aleandri

et al. 2020

Front. Cell. Infect. Microbiol.

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Allergic rhinitis (AR) and adenoid hypertrophy (AH) are, in children, the main cause of partial or complete upper airway obstruction and reduction in airflow. However, limited data exist about the impact of the increased resistance to airflow, on the nasal microbial composition of children with AR end AH. Allergic rhinitis (AR) as well as adenoid hypertrophy (AH), represent extremely common pathologies in this population. Their known inflammatory obstruction is amplified when both pathologies coexist. In our study, the microbiota of anterior nares of 75 pediatric subjects with AR, AH or both conditions, was explored by 16S rRNA-based metagenomic approach. Our data show for the first time, that in children, the inflammatory state is associated to similar changes in the microbiota composition of AR and AH subjects respect to the healthy condition. Together with such alterations, we observed a reduced variability in the between-subject biodiversity on the other hand, these same alterations resulted amplified by the nasal obstruction that could constitute a secondary risk factor for dysbiosis. Significant differences in the relative abundance of specific microbial groups were found between diseased phenotypes and the controls. Most of these taxa belonged to a stable and quantitatively dominating component of the nasal microbiota and showed marked potentials in discriminating the controls from diseased subjects. A pauperization of the nasal microbial network was observed in diseased status in respect to the number of involved taxa and connectivity. Finally, while stable co-occurrence relationships were observed within both control- and diseases-associated microbial groups, only negative correlations were present between them, suggesting that microbial subgroups potentially act as maintainer of the eubiosis state in the nasal ecosystem. In the nasal ecosystem, inflammation-associated shifts seem to impact the more intimate component of the microbiota rather than representing the mere loss of microbial diversity. The discriminatory potential showed by differentially abundant taxa provide a starting point for future research with the potential to improve patient outcomes. Overall, our results underline the association of AH and AR with the impairment of the microbial interplay leading to unbalanced ecosystems.

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“…The results of the ImmunoCAP system were given as exact values in UA/mL. Values of 0.35 UA/mL or higher were taken as a sign of sensitization (Yamamoto-Hanada et al, 2017 ).…”

Section: Methodsmentioning

confidence: 99%

16S Metagenomics Reveals Dysbiosis of Nasal Core Microbiota in Children With Chronic Nasal Inflammation: Role of Adenoid Hypertrophy and Allergic Rhinitis

Migliori

Zicari

Aleandri

et al. 2020

Front. Cell. Infect. Microbiol.

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“…A systematic review demonstrated that the pooled lifetime and point prevalence of self-reported FA was 17.3% (95% CI 17.0–17.6) in Europe [ 36 ]. From a large-scale birth cohort study (JECS Study), the prevalences of asthma, allergic rhinitis (hay fever), atopic dermatitis, and food allergy were 10.9, 36.0, 15.7 and 4.8%, respectively, among 99,013 mothers in Japan [ 37 ]. In addition, 73.9% mothers had positive IgE sensitization.…”

Section: Discussionmentioning

confidence: 99%

Early aggressive intervention for infantile atopic dermatitis to prevent development of food allergy: a multicenter, investigator-blinded, randomized, parallel group controlled trial (PACI Study)—protocol for a randomized controlled trial

Yamamoto‐Hanada

Kobayashi

Williams

et al. 2018

Clin Transl Allergy

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BackgroundAtopic dermatitis is the first clinical manifestation of the atopic march, with the highest incidence in the first year of life. Those affected often go on to develop other allergic diseases including food allergy, asthma, and allergic rhinitis. Recent evidence suggests that sensitization to foods may occur through a defective skin barrier which is common in atopic dermatitis in early life. We hypothesize that therapeutic aggressive intervention to treat new onset atopic dermatitis may prevent the development of later allergen sensitization, and associated food allergy, asthma, and allergic rhinitis.MethodsThis study is a multi-center, pragmatic, two-parallel group, assessor-blind, superiority, individually randomized controlled trial. Atopic dermatitis infants (N = 650) 7–13 weeks old who develop an itchy rash within the previous 28 days are randomly assigned to the aggressive treatment or the conventional treatment in a 1:1 ratio. The primary outcome is oral food challenge-proven IgE-mediated hen’s egg allergy at the age of 28 weeks.DiscussionThis is a novel pragmatic RCT study to examine the efficacy of early aggressive treatment for atopic dermatitis to prevent later food allergy. If our hypothesis is correct, we hope that such a strategy might impact on disease prevention in countries where food allergy is common, and that our results might reduce the frequency and associated costs of all food allergies as well as hens egg food allergy. Long-term follow and other similar studies will help to determine whether such a strategy will reduce the burden of other allergic diseases such as asthma and allergic rhinitis.Trial registration UMIN-CTR: UMIN000028043Electronic supplementary materialThe online version of this article (10.1186/s13601-018-0233-8) contains supplementary material, which is available to authorized users.

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“…Although it is not a clinical trial, the Japan Environment and Children’s Study (JECS) is registered with the University Hospital Medical Information Network Clinical Trials Registry, number UMIN000030786. The JECS is a nationwide, multicentre, prospective birth cohort study conducted by the Ministry of Environment of Japan, and its protocol and major hypotheses have been published as a protocol paper [ 12 – 15 ]. A total of 103,099 pregnant women were recruited from the general population of Japan for the JECS at 15 research centres covering a wide geographical area of Japan, from the north of the country (Hokkaido) to the south (Okinawa), from April 2011 to March 2014.…”

Section: Methodsmentioning

confidence: 99%

“…The prevalence of asthma and eczema among Japanese children is 13.3% and 24.5%, respectively [ 11 ]. According to a nationwide birth cohort study, about 36% of pregnant women in Japan have a history of pollinosis and 55.6% are IgE-sensitised to Japanese cedar [ 12 ]. Given the relatively high prevalence of allergies in Japan, it is important to investigate potential triggers and preventions for the development of this condition.…”

Section: Introductionmentioning

confidence: 99%

Cumulative inactivated vaccine exposure and allergy development among children: a birth cohort from Japan

Yamamoto‐Hanada

Pak

Saito‐Abe

et al. 2020

Environ Health Prev Med

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Background Adjuvants used in inactivated vaccines often upregulate type 2 immunity, which is dominant in allergic diseases. We hypothesised that cumulative adjuvant exposure in infancy may influence the development of allergies later in life by changing the balance of type 1/type 2 immunity. We examined the relationship between immunisation with different vaccine types and later allergic disease development. Methods We obtained information regarding vaccinations and allergic diseases through questionnaires that were used in The Japan Environment and Children’s Study (JECS), which is a nationwide, multicentre, prospective birth cohort study that included 103,099 pregnant women and their children. We examined potential associations between the initial vaccination before 6 months of age and symptoms related to allergies at 12 months of age. Results Our statistical analyses included 56,277 children. Physician-diagnosed asthma was associated with receiving three (aOR 1.395, 95% CI 1.028–1.893) or four to five different inactivated vaccines (aOR 1.544, 95% CI 1.149–2.075), compared with children who received only one inactivated vaccine. Similar results were found for two questionnaire-based symptoms, i.e. wheeze (aOR 1.238, 95% CI 1.094–1.401; three vaccines vs. a single vaccine) and eczema (aOR 1.144, 95% CI 1.007–1.299; four or five vaccines vs. a single vaccine). Conclusions Our results, which should be cautiously interpreted, suggest that the prevalence of asthma, wheeze and eczema among children at 12 months of age might be related to the amount of inactivated vaccine exposure before 6 months of age. Future work should assess if this association is due to cumulative adjuvant exposure. Despite this possible association, we strongly support the global vaccination strategy and recommend that immunisations continue. Trial registration UMIN000030786 .

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Allergic profiles of mothers and fathers in the Japan Environment and Children’s Study (JECS): a nationwide birth cohort study

Cited by 42 publications

References 21 publications

16S Metagenomics Reveals Dysbiosis of Nasal Core Microbiota in Children With Chronic Nasal Inflammation: Role of Adenoid Hypertrophy and Allergic Rhinitis

16S Metagenomics Reveals Dysbiosis of Nasal Core Microbiota in Children With Chronic Nasal Inflammation: Role of Adenoid Hypertrophy and Allergic Rhinitis

Early aggressive intervention for infantile atopic dermatitis to prevent development of food allergy: a multicenter, investigator-blinded, randomized, parallel group controlled trial (PACI Study)—protocol for a randomized controlled trial

Cumulative inactivated vaccine exposure and allergy development among children: a birth cohort from Japan

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