Allergic reactions to foods by inhalation

James, John M.; Crespo, Jesús F.

doi:10.1007/s11882-007-0017-z

Cited by 66 publications

(43 citation statements)

References 45 publications

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“…In a PubMed database search, no previous study assessing the risk of adverse respiratory effects in relation to inhalation of milk powder was identified, but the present results are consistent with four case reports of occupational asthma [22], one arising from exposure to lactalbumin in a chocolate candy worker [23] and another from the same protein in a bakery worker [24], one from exposure to casein sprayed while tanning leather [25] and another from sodium caseinate exposure in a delicatessen factory worker [26]. These studies also reported three cases of occupational rhinitis caused by milk proteins [23,25].…”

Section: Synthesis With Previous Knowledgesupporting

confidence: 88%

Respiratory effects of occupational exposures in a milk powder factory

Sripaiboonkij

Phanprasit²,

Jaakkola³

2007

Eur Respir J

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Ingestion of milk powder is a known cause of allergies in children, but the risks to respiratory health from exposure to inhaled milk powder have not been studied previously. The aim of the present study was to assess the effects of occupational exposures in a milk powder factory on respiratory symptoms and lung function.A cross-sectional study was conducted on 167 milk powder factory workers (response rate 77%) and 76 office workers (73%) from four factories in Thailand. All participants answered a questionnaire and performed spirometry. Measurements of concentrations of dust were used to give additional information on exposures.Mean respirable dust concentrations in the factory were 0.02-2.18 mg?m -3. The risk of breathlessness and nasal symptoms were significantly increased in production and packing staff. The risk of skin symptoms was significantly increased in those adding vitamin mixture to milk powder. Factory workers showed significantly lower forced expiratory volume in one second measured as percentage of predicted value.The present study provides new evidence that workers exposed to milk powder by inhalation are at an increased risk of nasal symptoms, wheezing and breathlessness, and exhibit reduced spirometric lung function, even at relatively low air concentrations of milk dust.

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Section: Synthesis With Previous Knowledgesupporting

confidence: 88%

Respiratory effects of occupational exposures in a milk powder factory

Sripaiboonkij

Phanprasit²,

Jaakkola³

2007

Eur Respir J

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“…In domestic settings, a Spanish study reported 11% of children from a group of 197 children with fish allergy/hypersensitivity, placed on a strict fish avoidance diet, who experienced repeated allergic reactions upon incidental inhalation of fish odors or vapors. In most cases, these episodes occurred at home when other people were eating fish (James & Crespo, 2007). A similar observation in a South African study of 105 individuals with self-reported seafood allergy, reported 30% of individuals with allergic symptoms after handling or inhaling seafood in the domestic home environment ).…”

Section: Occupational/inhalant Allergy and Asthma Associated With Seasupporting

confidence: 59%

Characterization of Seafood Proteins Causing Allergic Diseases

Rahman¹,

Helleur²,

Jeebhay³

et al. 2012

Allergic Diseases - Highlights in the Clinic, Mechanisms and Treatment

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“…An increasing number of studies have documented allergic reactions to food following inhalation, especially in occupational environments [17]. Respiratory allergy to animal food allergens is well known for fish and shellfish as well as for egg proteins, which become aerosolized in the food-processing industries [18,19,20,21].…”

Section: Discussionmentioning

confidence: 99%

Occupational Inhalant Allergy to Pork followed by Food Allergy to Pork and Chicken: Sensitization to Hemoglobin and Serum Albumin

Hilger

Swiontek

Hentges

et al. 2009

Int Arch Allergy Immunol

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Background: Animal-derived proteins are implicated in primary food allergies, but also in inhalant allergies with secondary food allergy symptoms. The objective of this study was to define the allergen(s) implicated in a case of food allergy to chicken meat, which developed in a person previously sensitized to pork after occupational exposure. Methods: A 42-year-old female with a history of occupational inhalant allergy to pork reported rhinitis, asthma, dysphonia and conjunctivitis 30 min after ingestion of chicken. Skin tests were positive to chicken meat. Protein extracts were prepared from chicken meat. Allergens were characterized by IgE immunoblotting, N-terminal sequencing and ELISA. Results: The patient showed specific IgE binding to chicken meat proteins at 12, 14, 26, 55 and 65 kDa. N-terminal amino acid sequencing identified the 12- and 14-kDa proteins as the α- and β-chain of hemoglobin. ELISA and immunoblot showed specific IgE binding to hemoglobin purified from chicken blood. IgE antibodies to chicken serum albumin were detected by ELISA. Inhibition studies with chicken and porcine hemoglobin as well as with serum albumins demonstrated cross-reactive IgE antibodies. Conclusions: We report a case of confirmed occupational inhalant allergy due to pork followed by food allergy to pork and 3 years later by food allergy to chicken. Porcine and chicken hemoglobin were found to be cross-reactive allergens. Cross-reactivity between porcine and chicken serum albumin was possibly linked to a prior sensitization to cat serum albumin.

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Allergic reactions to foods by inhalation

Cited by 66 publications

References 45 publications

Respiratory effects of occupational exposures in a milk powder factory

Respiratory effects of occupational exposures in a milk powder factory

Characterization of Seafood Proteins Causing Allergic Diseases

Occupational Inhalant Allergy to Pork followed by Food Allergy to Pork and Chicken: Sensitization to Hemoglobin and Serum Albumin

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