Allergic rhinitis in children with asthma: a questionnaire‐based study

Hamouda, S.; Karila, C.; Connault, T; Scheinmann, P.; Blic, J. de

doi:10.1111/j.1365-2222.2008.02953.x

Cited by 65 publications

(43 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Asthma Asthma frequently coexists with AR being seen in half to three quarter of children and teenagers with asthma in a range of studies (37)(38)(39)(40). Asthma is similarly associated with nonallergic rhinitis as demonstrated by the COPSAC highrisk birth cohort (41).…”

Section: Other Comorbiditiesmentioning

confidence: 99%

Paediatric rhinitis: position paper of the European Academy of Allergy and Clinical Immunology

Roberts

Xatzipsalti

Borrego

et al. 2013

Allergy

317

248

View full text Add to dashboard Cite

Rhinitis is a common problem in childhood and adolescence and impacts negatively on physical, social and psychological well-being. This position paper, prepared by the European Academy of Allergy and Clinical Immunology Taskforce on Rhinitis in Children, aims to provide evidence-based recommendations for the diagnosis and therapy of paediatric rhinitis. Rhinitis is characterized by at least two nasal symptoms: rhinorrhoea, blockage, sneezing or itching.

show abstract

Section: Other Comorbiditiesmentioning

confidence: 99%

Paediatric rhinitis: position paper of the European Academy of Allergy and Clinical Immunology

Roberts

Xatzipsalti

Borrego

et al. 2013

Allergy

317

248

View full text Add to dashboard Cite

show abstract

“…AR frequently coexists with asthma (most studies report a rate of 50-60%) in children (3). The major histological features of AR include helper T cell type-2 (Th2) inflammation accompanied by infiltration with eosinophils, allergen-specific IgE production, and thickening of the basement membrane (4,5).…”

mentioning

confidence: 99%

Interleukin-31 promotes helper T cell type-2 inflammation in children with allergic rhinitis

et al. 2014

View full text Add to dashboard Cite

Background: Interleukin-31 (IL-31) is a recently described cytokine that is involved in helper T cell type-2 (Th2)-mediated diseases. However, its regulatory effect in the pathogenesis of children allergic rhinitis (AR) needs to be further characterized. This study sought to evaluate the expression and role of IL-31 in children with AR. Methods: Sixty children with AR and 20 normal controls were included. IL-31 and Th2 cytokines production in tissue, serum, and nasal lavage was examined by immunohistochemistry, quantitative polymerase chain reaction (qPCR), and enzyme-linked immunosorbent assay, respectively. Peripheral blood mononuclear cells (PBMCs) were purified for in vitro regulation experiment of IL-31. Nasal epithelial cells (NECs) were cultured and stimulated by recombinant IL-31. results: The IL-31 mRNA and protein levels in both serum and nasal lavage were significantly enhanced in AR compared with normal controls, especially in children with asthma. The nasal IL-31 was associated with enhanced local Th2 cytokines and mucin 5AC (MUC5AC) expression. In vitro study showed that IL-31 promotes Th2 cytokines expression and MUC5AC upregulation and thus amplified Th2 inflammation. conclusion: Our results demonstrate that IL-31 expression in AR aggravated and amplified Th2 inflammation as well as mucin production, and provide a possible explanation for IL-31's regulatory role in the pathogenesis of AR. a llergic rhinitis (AR) is a common nasal disease and affects 10-40% of children with increasing prevalence (1,2). AR frequently coexists with asthma (most studies report a rate of 50-60%) in children (3). The major histological features of AR include helper T cell type-2 (Th2) inflammation accompanied by infiltration with eosinophils, allergen-specific IgE production, and thickening of the basement membrane (4,5). Activation of Th2 cells and further released cytokines induced accumulation of inflammatory cells, such as B cells, plasma cells, eosinophils, basophils, and neutrophils, which contributed to the occurrence of AR (6). Despite involvement of Th2 inflammation in AR was clearly clarified, its regulation was not fully understood.Interleukin-31 (IL-31) is a newly discovered four-helix bundle cytokine and expressed by several types of cells under both normal and disease state, such as activated CD4 + T cells, mast cells, monocytes, macrophages, immature and mature monocyte-derived dendritic cells and so on (7). The receptor of IL-31 consists of IL-31 receptor A (IL-31RA) and the oncostatin M receptor that is constitutively expressed on epithelial cells (8). The role of IL-31 in allergic diseases mainly focused on atopic dermatitis. Stephan et al. reported elevated IL-31 expression in atopic dermatitis (9). UIrike et al. found a correlation of Th2 cytokines with increased level of IL-31 in children with extrinsic atopic dermatitis (10). However, studies on respiratory allergic diseases are relatively few. Recently, Lei et al. (11) reported that high IL-31 level in asthmatic subjects, suggesting that IL-31 ...

show abstract

“…In our cohort of asthmatic children, whose demographic characteristics largely reflect that of lower socioeconomic classes, we find a prevalence of rhinitis of 51.3% within the last 2 weeks and 71.3% in the last year, which is consistent with previous studies of asthmatic children. [2][3][4][5] Previous work has highlighted a similarly high prevalence of AR in the urban pediatric population, with underserved children at higher risk for undiagnosed AR 27 and up to two thirds of these children reportedly receiving inadequate or no treatment for AR. 28 Mouse and cockroach allergens have been previously reported to be the two most abundant aeroallergens in many urban communities 15 and our results here, identifying mouse sensitivity by serology as the dominant association with active rhinitis is also consistent with previous work reporting the dominance of mouse over cockroach allergy in asthma outcomes in a similar cohort of urban children.…”

Section: Discussionmentioning

confidence: 99%

“…1 Approximately 40% of children with AR carry a concurrent diagnosis of asthma and 60 to 80% of children with asthma may have AR. [2][3][4][5] In addition to the direct impact on a child's health and quality of life, 2,6 AR is associated with poorly controlled asthma in children. [7][8][9] Asthma exacerbations and asthma-related emergency department (ED) visits also are associated with AR 10 and treatment of AR in individuals with asthma is associated with reductions in asthmarelated hospital admissions and ED visits.…”

Section: Introductionmentioning

confidence: 99%

Mouse Sensitivity Is an Independent Risk Factor for Rhinitis in Children with Asthma

Sedaghat

Matsui

Perzanowski

et al. 2015

Journal of Allergy and Clinical Immunology

View full text Add to dashboard Cite

show abstract

Allergic rhinitis in children with asthma: a questionnaire‐based study

Abstract: AR and asthma are frequently associated (58.7%). The SFAR adapted for children seems to be a simple and a reliable tool to detect AR in asthmatic children.

Cited by 65 publications

References 37 publications

Paediatric rhinitis: position paper of the European Academy of Allergy and Clinical Immunology

Paediatric rhinitis: position paper of the European Academy of Allergy and Clinical Immunology

Interleukin-31 promotes helper T cell type-2 inflammation in children with allergic rhinitis

Mouse Sensitivity Is an Independent Risk Factor for Rhinitis in Children with Asthma

Contact Info

Product

Resources

About