Allergies and Eosinophilic Esophagitis—Current Updates for the Pediatric Gastroenterologist

Williamson, Prerana; Aceves, Seema S.

doi:10.1007/s11894-019-0729-y

Cited by 14 publications

(15 citation statements)

References 79 publications

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“…Furthermore, clinical reports reveal that aeroallergens prevalent in the environment during pollen season as well as mites and mold serve as triggers for relapses in patients with symptom-controlled EoE [43,44]; our findings are consistent with these observations. Furthermore, Williamson et al [45] found that that IgE-mediated allergies may play a role with respect to the severity and clinical course of EoE. Taken together, these reports reinforce our findings that suggest that IgEmediated sensitization by a variety of allergens, including mainly indoor and animal allergens, may be related to exacerbation the clinical status of patients diagnosed with EE.…”

Section: Discussionsupporting

confidence: 91%

Classification of patients with esophageal eosinophilia by patterns of sensitization revealed by a diagnostic assay for multiple allergen-specific IgEs

et al. 2021

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BackgroundEosinophilic esophagitis (EoE) is considered to be an immunoglobulin E (IgE)-mediated allergic disorder. Our goal was to examine IgE-mediated allergic sensitization patterns in patients with esophageal eosinophilia (EE). MethodsWe enrolled subjects with EE who underwent evaluation with a diagnostic panel to document multiple allergen-specific IgEs. Statistically significant groups were identified by cluster analysis. We also defined allergens based on their characteristics including outdoor, indoor, plant, and animal allergens. ResultsWe classified patients with EE into 3 distinct groups, including cluster 1 (n = 62) who were minimally sensitized to most allergens except pollen and house dust, cluster 2 (n = 30) who were hypersensitized to outdoor and plant allergens, and cluster 3 (n = 15) who were hypersensitized to most allergens, most notably to indoor and animal allergens.Dysphagia reported among those in clusters 1, 2, and 3 at 35.5%, 46.7%, and 73.3%, respectively, (p = 0.028) and EoE endoscopic reference scores (EREFS) at 3.0, 6.0, and 8.0, respectively (p < 0.001) differed significantly between the 3 clusters. Those in cluster 4 3 had significantly higher prevalence of dysphagia (35.5% vs. 73.3%, p = 0.030), and higher EREFS with respect to rings (0.3 vs. 0.9, p = 0.003) and strictures (0.0 vs. 0.13, p = 0.011) compared to those in cluster 1. ConclusionsIgE-mediated allergic sensitization patterns are associated with clinical features of patients with EE. Use of a diagnostic panel that detects multiple allergen-specific IgEs can help to explain the heterogeneous phenotype of this patient cohort.

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Section: Discussionsupporting

confidence: 91%

Classification of patients with esophageal eosinophilia by patterns of sensitization revealed by a diagnostic assay for multiple allergen-specific IgEs

et al. 2021

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“…The administration of the initial doses under clinical control is recommended [20]. Some patients who perform OIT may also develop eosinophilic esophagitis for which desensitizing treatment is stopped [148,149]. The OIT rationale and its greater efficacy compared to other forms of specific immunotherapy in FA is based on the fact that the ingestion of a food antigen preferentially determines a tolerogenic active immune response rather than allergic sensitization [150].…”

Section: Specific Immunotherapymentioning

confidence: 99%

New Perspectives in Food Allergy

Martinis

Sirufo

Suppa

et al. 2020

IJMS

175

130

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The improvement of the knowledge of the pathophysiological mechanisms underlying the tolerance and sensitization to food antigens has recently led to a radical change in the clinical approach to food allergies. Epidemiological studies show a global increase in the prevalence of food allergy all over the world and manifestations of food allergy appear increasingly frequent also in elderly subjects. Environmental and nutritional changes have partly changed the epidemiology of allergic reactions to foods and new food allergic syndromes have emerged in recent years. The deepening of the study of the intestinal microbiota has highlighted important mechanisms of immunological adaptation of the mucosal immune system to food antigens, leading to a revolution in the concept of immunological tolerance. As a consequence, new prevention models and innovative therapeutic strategies aimed at a personalized approach to the patient affected by food allergy are emerging. This review focuses on these new perspectives and their practical implications in the management of food allergy, providing an updated view of this complex pathology.

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“…Although no particular features identified in a physical examination are specific for an EoE diagnosis, it is useful to identify signs of comorbid allergic diseases; it is estimated that in the paediatric population with EoE, between 40-90% of patients have another allergic disease. The majority of EoE patients have sensitisation to food, aeroallergens, or both, and 15-43% have IgE-mediated food allergies [3,5,7,8,9].…”

Section: Introductionmentioning

confidence: 99%

Correlation of clinical symptoms, endoscopic features and density of oesophageal eosinophilia in children with newly-diagnosed eosinophilic esophagitis

Załęski¹,

Banasiuk²,

Sokół-Łupińska³

et al. 2021

Ann Agric Environ Med.

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Allergies and Eosinophilic Esophagitis—Current Updates for the Pediatric Gastroenterologist

Cited by 14 publications

References 79 publications

Classification of patients with esophageal eosinophilia by patterns of sensitization revealed by a diagnostic assay for multiple allergen-specific IgEs

Classification of patients with esophageal eosinophilia by patterns of sensitization revealed by a diagnostic assay for multiple allergen-specific IgEs

New Perspectives in Food Allergy

Correlation of clinical symptoms, endoscopic features and density of oesophageal eosinophilia in children with newly-diagnosed eosinophilic esophagitis

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