Allergische Atemwegsobstruktion (Allergisches — extrinsic — Asthma bronchiale)

Fuchs, Ernst

doi:10.1007/978-3-642-67073-2_14

Cited by 5 publications

(3 citation statements)

References 315 publications

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“…Under the influence of allergens, specific IgE antibodies are formed which attach with their Fc part to the receptors of the tissue mastocytes and in the plasma to the receptors of basophilic leucocytes (target cells). Under the influence of the allergen the basophilic granules are released by these cells, which in turn enable vasoactive substances such as histamine serotonin, bradykinin, prostaglandins (El, E2 and F2), as well as other anaphylactic agents to reach the blood and tissue [7,8].…”

Section: Discussionmentioning

confidence: 99%

Drug‐resistant bronchial asthma successfully treated with plasma exchange

Bambauer¹,

Jutzler²,

Micka³

et al. 1984

J of Clinical Apheresis

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Two patients suffering from allergic bronchial asthma who showed no improvement despite six and four weeks, respectively, of drug therapy were successfully treated with therapeutic plasma exchange. The first patient had no attacks over a period of five months, and the other patient had none for over one year. Although this report only deals with single observations, we believe that therapeutic plasma exchange is of particular value for patients with severe allergic bronchial asthma because it eliminates in addition to immunocomplexes other substances, including antigens, rapidly from the blood. This means that it is possible to directly intervene in the pathomechanism. However, further investigations are necessary in order to corroborate this successful therapy.

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Section: Discussionmentioning

confidence: 99%

Drug‐resistant bronchial asthma successfully treated with plasma exchange

Bambauer¹,

Jutzler²,

Micka³

et al. 1984

J of Clinical Apheresis

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“…Apart from the /f-adrenergic weakness, atopic pa tients have been shown to be hypersensitive to a-adrenergic and cholinergic stimuli in vivo: the increased reactivity after inhala tion challenge with methylcholine is routine ly used in clinical diagnosis of bronchial asthma [7]; atopies require a significantly smaller amount of phenylephrine for pupil lary dilation than controls [11].…”

Section: Discussionmentioning

confidence: 99%

“…Whereas /1-adrenergic blockade is well-defined in vitro and in vivo both at the cellular and the smooth muscle level [4,20,22,23,27,40], the phenomenon of choli nergic hyperreactivity is regarded to be the function of a hyperreactive smooth muscle by most authors [7,14]. Mast cells are known to also have cholinergic receptors [6,15,24,32], stimulation of which enhances IgE-induced histamine release [37,38].…”

Section: Discussionmentioning

confidence: 99%

In vitro Cyclic Nucleotide Responsiveness of Leukocytes and Platelets in Patients Suffering from Atopic Dermatitis

Ring¹,

Mathison²,

O’Connor³

1981

Int Arch Allergy Immunol

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Peripheral blood leukocytes from patients with severe atopic dermatitis (serum IgE levels between 1,560 and 28,000 U/ml) showed a significantly weaker increase in intracellular cAMP after stimulation with epinephrine (10^––⁵–10^––3M) than leukocytes from normals. At the same time stimulation with methylcholine (10^––10–10^––4M) induced a significantly higher increase in intracellular levels of cGMP in the atopic group compared to normals. The immunomodulating agent levamisole induced a slight increase in cAMP and cGMP response both in leukocytes from atopic patients and in normals. Platelet cAMP concentrations were lowered by epinephrine stimulation both in atopies and controls. There was no effect of methylcholine upon platelet cyclic nucleotide levels in the dose range examined. The data support the concept that abnormal cyclic nucleotide responsiveness – not only as β-adrenergic blockade but also as cholinergic hyperreactivity – may play a role in the pathogenesis of atopic dermatitis.

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Allergiediagnostik

Gonsior¹

2000

Pneumologische Prävention Und Rehabilitation

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Allergische Atemwegsobstruktion (Allergisches — extrinsic — Asthma bronchiale)

Cited by 5 publications

References 315 publications

Drug‐resistant bronchial asthma successfully treated with plasma exchange

Drug‐resistant bronchial asthma successfully treated with plasma exchange

In vitro Cyclic Nucleotide Responsiveness of Leukocytes and Platelets in Patients Suffering from Atopic Dermatitis

Allergiediagnostik

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