Allergy and risk of hematologic malignancies: Associations and mechanisms

Abstract

Increasing evidence indicates that a dysregulated immune system, as the one found in allergic disorders, can affect survival of tumor cells. A possible association between allergies and risk of hematologic malignancies has been examined in several epidemiological studies; however, results were not always consistent. The aim of this review is to report the preclinical and clinical data, which support a correlation between allergy and hematologic neoplasms. Immune system modulation could represent a powerful tool in the prevention and treatment of hematologic malignancies.

Gambaran Hubungan Regimen Dosis Danefek Samping Kemoterapi pada Pasien Kanker di RSUD Prof Dr. Margono Soekarjo Purwokerto Periode Bulan Januari-Februari Tahun 2019

“…Penelitian melaporkan adanya hubungan antara alergi dan limfoma atau leukimia akut. Faktanya hanya pada penyakit ini korelasi terkuat dengan status alergi yang dapat dideteksi, sementara penyakit hematologi yang lain dilaporkan sporadis dan kadang-kadang saja (Musolino et al, 2014). Efek samping yang terjadi selanjutnya adalah mual sebanyak 11 pasien (7,3%).…”

Allergic disease, corticosteroid use, and risk of Hodgkin lymphoma: A United Kingdom nationwide case-control study

“…[24][25][26] There is a growing body of evidence supporting this hypothesis and showing that a number of immune-related cancers, including leukemia, occur as a consequence of immune system malfunction in early life. [27][28][29] Allergic diseases, including asthma, eczema, and allergic rhinitis, are among the most common perpetrators of chronic immune stimulation. Few studies have investigated the link between allergic diseases and HL, and the results have been conflicting and inconclusive.…”

The link between neoplastic and atopic diseases

“…Reduced levels of IgE and histamine have been found in patients with neoplastic diseases. IL-12 is an anti-allergic inflammation cytokine that stimulates T cells and NK cells as well as the production of INF gamma, which stimulates macrophages to kill neoplastic cells [3,4]. Perhaps these described reactions explain the lower incidence of chronic leukemia in atopy patients.…”

“…− The second one proposes a relation between atopy and an increased risk of neoplastic diseases, stemming from chronic stimulation of the immunological system [1,2,3]. According to the first hypothesis, the overstimulation of immunocompetent cells, which results from contact with an allergen, causes the production of certain IgE antibodies that may have a cytotoxic influence on neoplastic cells.…”

“…Damage to the oxidative pathways of cells induces the mutation of suppressor genes and posttranslational modifications of proteins responsible for DNA repair processes or apoptosis process control. The transition in the Th1/Th2 balance towards Th2 lymphocytes among allergy patients fosters inhibition of correct production processes of cytotoxic effector cells and simultaneously lowers their ability to eliminate neoplastic cells [3,4]. What these two theories have in common is the field of "allergo-oncology", which analyzes the correlation between the immunological system and the occurrence of neoplastic diseases [5].…”