Allergy and the Skin

Dahl, M.G.C.

doi:10.1007/978-94-011-6217-3_6

Cited by 5 publications

(2 citation statements)

References 160 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The high serum levels of IgE in atopic eczema have, therefore, not been considered as supporting a pathological role for IgE antibodies in this condition [12][13][14][15], although one could argue that this may merely reflect the investigators' failure to identify the relevant allergen. It is fairly obvious that the present eczema patients could be divided up into two groups; namely those with demonstrable spe cific IgE and those without.…”

Section: Discussionmentioning

confidence: 99%

Relevance of Milk- and Egg-Specific IgG4 in Atopic Eczema

Shakib

Brown

Stanworth

1984

Int Arch Allergy Immunol

View full text Add to dashboard Cite

In a substantial proportion of atopic eczema patients clinical sensitivity to food is not confirmable by either skin prick test or IgE RAST. The diagnosis of provocative food factors in this condition is, therefore, highly dependent on dietary manipulations which are time consuming and sometimes dangerous. In an attempt to find an alternative laboratory procedure we have questioned the clinical relevance of specific IgG4 measurement in the sera of these patients in the light of previous reports demonstrating raised total serum IgG4 in patients with atopic eczema. Thus, a highly reliable ELISA was developed to measure IgG4 specific to 3 cow’s milk proteins and 2 hen’s egg proteins in the sera of milk- and egg-allergic eczema patients and non-eczematous controls. The study provides clear evidence showing that the detection of milk- and egg-specific IgG4 in atopic eczema patients has no clinical value.

show abstract

Section: Discussionmentioning

confidence: 99%

Relevance of Milk- and Egg-Specific IgG4 in Atopic Eczema

Shakib

Brown

Stanworth

1984

Int Arch Allergy Immunol

View full text Add to dashboard Cite

show abstract

“…At present there is considerable nihilism about the role of allergens in atopic dermatitis (Norins, 1971;Dahl, 1981). Nonetheless it is clear that many of the patients are allergic to house dust and are also exposed to house dust; this raises several questions.…”

mentioning

confidence: 99%