Quantitative assessments of IgG and IgE antibodies to inhalant allergens in patients with atopic dermatitis

Chapman, Martin D.; Rowntree, S.; Mitchell, E. B.; Fuenmajor, M.C. Di Prisco de; Platts‐Mills, Thomas A.E.

doi:10.1016/0091-6749(83)90048-9

Cited by 117 publications

(56 citation statements)

References 35 publications

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“…In conclusion, the present study delineates for the first time a differential but partially overlapping role of FcRI and CD16 in a mouse model reproducing some features of AD physiopathology, where the contribution of IgG immune complexes was documented but poorly understood (50). Even if considerable differences exist between mice and humans regarding identity, structure, cell distribution, and/or isotype specificity of Fc␥R and FcRI, we might nevertheless speculate that the partial inhibition obtained by targeting only IgE/FcRI interactions, using anti-IgE, in asthma (51) or atopic skin reactions (52) might be due to a significant contribution of CD16 or other Fc␥R to the pathology.…”

Section: Discussionmentioning

confidence: 97%

FcεRI and FcγRIII/CD16 Differentially Regulate Atopic Dermatitis in Mice

Abboud

Staumont‐Sallé

Kanda

et al. 2009

The Journal of Immunology

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The high-affinity IgE receptor FcεRI and, in some models, the low-affinity IgG receptor FcγRIII/CD16 play an essential role in allergic diseases. In human skin, they are present on APCs and effector cells recruited into the inflamed dermis. FcRγ is a subunit shared, among other FcRs, by FcεRI and CD16 and is essential to their assembly and signal transduction. Using an experimental model reproducing some features of human atopic dermatitis and specific FcR-deficient mice, we have herein delineated the respective contribution of FcεRI and FcγRIII/CD16 to the pathology. We demonstrate that symptoms of atopic dermatitis are completely absent in FcRγ-deficient animals but only partially inhibited in either FcεRI- or FcγRIII/CD16-deficient animals. Absence or attenuation of the pathology is correlated to increased skin expression of regulatory IL-10 and Foxp3. While FcεRI controls both Th1 and Th2 skin response, mast cell recruitment into draining lymph nodes and IgE production, CD16 regulates only Th2 skin response, as well as T cell proliferation and IgG1 production. This isotype-specific regulation by the cognate FcR is associated to a differential regulation of IL-4 and IL-21 expression in the draining lymph nodes. FcεRI and CD16 thus contribute to atopic dermatitis but differentially regulate immune responses associated with the disease. Targeting both IgE/FcεRI and IgG/CD16 interactions might represent an efficient therapeutic strategy for allergic diseases.

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Section: Discussionmentioning

confidence: 97%

FcεRI and FcγRIII/CD16 Differentially Regulate Atopic Dermatitis in Mice

Abboud

Staumont‐Sallé

Kanda

et al. 2009

The Journal of Immunology

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“…Although whether the biochemical functions of other major allergens have such a critical commitment to sensitization is an issue unsolved as yet (62,63), we consider that studies based on this question might be important in elucidation of the pathogenesis of allergic diseases, prevention of their development, and therapy (50,64,65). Interestingly, people who do not become allergic to house dust mites do not make IgG specific for major house dust mite allergens (62,63,66,67). The close link between allergenicity and immunogenicity of the major mite allergens in humans is similar to our results in mice where substantial increases in IgE, IgGs, and T cell responses were observed on immunization with active rDer p 1 but not on immunization with E-64-treated rDer p 1.…”

Section: Discussionmentioning

confidence: 99%

Crucial Commitment of Proteolytic Activity of a Purified Recombinant Major House Dust Mite Allergen Der p1 to Sensitization toward IgE and IgG Responses

Kikuchi

Takai²,

Kuhara³

et al. 2006

The Journal of Immunology

102

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The major proteolytic allergen derived from the house dust mite Dermatophagoides pteronyssinus, Der p1, is one of the most clinically relevant allergens worldwide. In the present study, we evaluate the contribution of the proteolytic activity and structure of a highly purified rDer p 1 to immune responses. Mice were i.p. immunized with three forms of rDer p 1 adsorbed to Alum: one enzymatically active, one treated with an irreversible cysteine protease-specific inhibitor, E-64, and one heat denatured. Immunization with E-64-treated or heat-denatured rDer p 1 elicited much less production of serum total IgE and not only rDer p 1-specific IgE but also IgGs compared with immunization with active rDer p 1. Assays for Ab-binding and its inhibition and structural analyses indicated that E-64-treated rDer p 1 retained its global structure and conformational B cell epitopes. A proliferative response and production of IL-5 by spleen cells restimulated with rDer p 1 were observed on immunization with the active rDer p 1 but not E-64-treated rDer p 1. The cells from mice immunized with heat-denatured rDer p 1 exhibited the highest levels of proliferation and production of IL-5 and IFN-γ. The results indicate that the proteolytic activity of the highly purified rDer p 1 crucially commits to the sensitization process, including both IgE and IgG responses. Additionally, we demonstrated immunogenic differences by functional or structural manipulations of the rDer p 1. The findings have implications for sensitization to this relevant allergen in humans and for the design of modified allergen-vaccines for future allergen-specific immunotherapy.

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“…3 Alergen makanan lebih berpengaruh pada usia bayi kurang dari 1 tahun sedangkan aeroalergen pada usia di atas 2 tahun. 4 H asil penelitian di Departemen IKA RSCM menunjukkan bahwa DA pada anak dengan onset kurang dari 1 tahun yang telah tersensitisasi telur dan aeroalergen akan meningkatkan risiko alergi saluran napas di kemudian hari sampai sepuluh kali lipat.…”

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Peran Alergi Makanan dan Alergen Hirup pada Dermatitis Atopik

Siregar

2016

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Sensitisasi makanan dan aeroalergen memegang peran pada patogenesis penyakit atopikseperti dermatitis atopik (DA), rinitis alergik dan asma. Dermatitis atopik merupakansuatu penyakit kronik yang tidak dapat disembuhkan 100% dan sering mengalamieksaserbasi, serta menimbulkan masalah pada orang tua dan dokter. Banyak faktor yangberperan pada DA, baik faktor eksogen atau endogen maupun kombinasi keduanya.Faktor genetik merupakan salah satu faktor yang berperan pada DA. Faktor eksogenseperti makanan aeroalergen banyak dilaporkan sebagai pencetus timbulnya DA. Masihterdapat perbedaan pendapat mengenai makanan sebagai penyebab tetapi terdapat buktibahwa bila makanan dihindarkan gejala dermatitis membaik. Susu sapi memprovokasigejala DA pada usia bayi1 dan 30% DA disebabkan alergi susu sapi2.Alergen hirup seperti tungau debu rumah berperan pada patogenesis DA, terutamapada anak; hal ini berdasarkan beberapa pengamatan klinis, uji kulit dan IgE spesifikyang tinggi serta terdapat perbaikan gejala klinis DA setelah penghindaran tungau deburumah.3 Alergen makanan lebih berpengaruh pada usia bayi kurang dari 1 tahunsedangkan aeroalergen pada usia di atas 2 tahun.4 H asil penelitian di Departemen IKARSCM menunjukkan bahwa DA pada anak dengan onset kurang dari 1 tahun yangtelah tersensitisasi telur dan aeroalergen akan meningkatkan risiko alergi saluran napasdi kemudian hari sampai sepuluh kali lipat

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Quantitative assessments of IgG and IgE antibodies to inhalant allergens in patients with atopic dermatitis

Cited by 117 publications

References 35 publications

FcεRI and FcγRIII/CD16 Differentially Regulate Atopic Dermatitis in Mice

FcεRI and FcγRIII/CD16 Differentially Regulate Atopic Dermatitis in Mice

Crucial Commitment of Proteolytic Activity of a Purified Recombinant Major House Dust Mite Allergen Der p1 to Sensitization toward IgE and IgG Responses

Peran Alergi Makanan dan Alergen Hirup pada Dermatitis Atopik

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