Allergy in asthma

Zimmerman, Barry J.; Feanny, Stephen; Reisman, Joseph; Hak, H.; Rashed, Nashed; McLaughlin, Fiona; Levison, Henry

doi:10.1016/0091-6749(88)90221-7

Cited by 109 publications

(8 citation statements)

References 21 publications

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“…This is consistent with previous observations relating atopy to the BDR (5, 16), asthma severity (26), bronchial hyper-reactivity (13, 17), induced sputum (2) and bronchial eosinophilia (15). This is clinically relevant since it directs the physician to consider environmental allergens in addition to pharmacotherapy in a more comprehensive approach to treatment.…”

Section: Discussionsupporting

confidence: 93%

The Relationship of the Bronchodilator Response Phenotype to Poor Asthma Control in Children with Normal Spirometry

Galant

Morphew

Newcomb

et al. 2011

The Journal of Pediatrics

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Objective The purpose of this study was to determine the relationship of poor asthma control to bronchodilator response (BDR) phenotypes in children with normal spirometry. Methods Asthmatic children were assessed for clinical indices of poorly controlled asthma. Pre and post bronchodilator spirometry were performed and the percent BDR determined. Multivariate logistic regression assessed the relationship of the clinical indices to BDR at ≥8%, ≥10% and ≥12% BDR thresholds. Results There were 510 controller naïve, and 169 on controller medication. In the controller naïve population the mean age (± 1SD) was 9.5 (3.4), 57.1% were male, 85.7% Hispanic. Demographics were similar in both populations. In the adjusted profile, significant clinical relationships were found particularly to positive BDR phenotypes ≥10% and ≥12% versus negative responses including younger age, (odds ratios (OR) 2.0, 2.5; P <.05), atopy (OR 1.9, 2.6;P< .01), nocturnal symptoms in females (OR 3.4, 3.8;P< .01); beta2 agonist use (OR 1.7, 2.8;P< .01); and exercise limitation (OR 2.2, 2.5;P< .01) only in the controller naïve population. Conclusions The BDR phenotype ≥10% is significantly related to poor asthma control providing a potentially useful objective tool in controller naïve children even when prebronchodilator spirometry is normal.

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Section: Discussionsupporting

confidence: 93%

The Relationship of the Bronchodilator Response Phenotype to Poor Asthma Control in Children with Normal Spirometry

Galant

Morphew

Newcomb

et al. 2011

The Journal of Pediatrics

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“…(11) Also, in a study of 123 children with asthma, the number and size of positive skin prick tests increased with increasing severity of asthma. (12)…”

Section: Atopy and Asthma Severitymentioning

confidence: 99%

Relevance of Allergy in Adult Asthma

Mathur

Viswanathan

2014

Curr Allergy Asthma Rep

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Recent studies on asthma have demonstrated multiple phenotypes of asthma, based on the clinical characteristics of the disease. With the current interest in personalized medicine, the question arises whether the presence of allergic sensitization has any relevance for these phenotypes and the management of asthma. This review will examine the current knowledge of asthma phenotypes and the impact of atopy on asthma diagnosis and severity in adults. In addition, this review will address whether therapies targeted at the atopic axis help improve asthma outcomes, including lung function indices and exacerbations.

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“…In clinical studies most asthmatic children are atopic 12. The strength of this association may, however, be attributable to population selection whereby more severe asthmatics, usually followed in tertiary referral centres, may tend to be more atopic than other children with asthma.…”

Section: Early Origins Of Asthmamentioning

confidence: 99%

Paediatric origins of adult lung disease bullet 6: Paediatric origins of adult lung disease

Mutius¹

2001

Thorax

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Allergy in asthma

Cited by 109 publications

References 21 publications

The Relationship of the Bronchodilator Response Phenotype to Poor Asthma Control in Children with Normal Spirometry

The Relationship of the Bronchodilator Response Phenotype to Poor Asthma Control in Children with Normal Spirometry

Relevance of Allergy in Adult Asthma

Paediatric origins of adult lung disease bullet 6: Paediatric origins of adult lung disease

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