Allergy to cow's milk presenting as chronic constipation.

Intolerance of Cow's Milk and Chronic Constipation in Children

“…However, as others have reported, constipation may be the only presenting symptom. 21,22 Furthermore, clinical examination of the children in our study showed a very high frequency of severe anal fissures. Because these lesions reappeared after the reintroduction of cow's milk and before the onset of constipation, we hypothesize that they are one of the mechanisms causing constipation.…”

Review article: chronic constipation and food hypersensitivity – an intriguing relationship

“…Although the association between cow's milk (CM) protein and chronic constipation had already been reported by Buisseret in 1978, 7 until our first prospective study 5 there were only two case reports in the literature indicating that constipation might be the only clinical manifestation of CMPH 8, 9 . However, it is interesting that many years before, Davidson et al .…”

Nuclear transit studies of patients with intractable chronic constipation reveal a subgroup with rapid proximal colonic transit

“…In 1963, Davidson et al [21] reported that constipation in pediatric patients considerably improved when treatment included the exclusion of CM and its derivatives from the diet. Subsequently, the association between CM protein and chronic constipation was reported by Buisseret [22] with 2 further case reports indicating that constipation might be the only clinical manifestation of CM protein intolerance (CMPI) [13,14]. During the 1999s, work from Carroccio et al [18] indicated a clear relationship between CMPI and chronic constipation in children unresponsive to laxative treatment [19] and showed that an exclusion diet was able to correct the constipation.…”

“…Food allergies are commonly encountered conditions affecting up to 8% of children younger than 10 years [11]. Constipation related to food intolerance has been increasingly reported [12][13][14][15][16][17][18][19], and the underlying pathophysiology of this entity is under study. Constipation has been identified as one of the most common gastrointestinal disorders in patients with atopic dermatitis and food allergy [11,20].…”