Allergy to Perfumes From Toilet Soaps and Detergents in Patients With Dermatitis

Rothenborg, Hans W.

doi:10.1001/archderm.1968.01610100057008

Cited by 53 publications

(14 citation statements)

References 9 publications

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“…Though our patients often undertook normal domestic duties, it is apparent that their exposure to perfumes was diminished because in the hospital, nonperfumed items are commonly used. Perfume allergy is often associated with dermatitis of the hands and forearms (Hjorth 1961, Rothenburg & Hjorth 1968) as in our material, as 70% of the perfume sensitive subjects had suffered from hand dermatitis. Nickel was the most common individual allergen, conforming with earlier observations (Wilkinson et al 1970.…”

Section: Discussionsupporting

confidence: 54%

Occurrence of contact allergy and hand eczemas in hospital wet work

1982

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The occurrence of contact sensitivity and hand dermatitis was studied in hospital employees. The incidence of contact allergy was 21%. Nickel (9%) was the most common allergen followed by perfumes (6%). Present of previous hand dermatitis was detected in 46%. Of those with positive reactions, 53% had suffered from hand dermatitis as compared to 44% of those without positive reactions. 70% of those with sensitivity to fragrances had suffered from hand dermatitis. The occurrence of hand dermatitis was more frequent in persons, who had developed contact allergy to rubber chemicals or to both nickel and cobalt simultaneously.

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Section: Discussionsupporting

confidence: 54%

Occurrence of contact allergy and hand eczemas in hospital wet work

1982

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“…In investigations from Germany, North America and Singapore, an increased frequency of reactions to the fragrance mix has also been detected within recent years, 3 , 4 , 16 while no increase has been seen in the U.K. 17 The use of fragrances is not covered by any official regulations, which is in contrast to other ingredients in cosmetics, such as preservatives. Balsam of Peru has also been used as an indicator of perfume allergy; 18 however, no changes in the prevalence of positive reactions were seen in the study period ( Fig. 1).…”

Section: Discussionmentioning

confidence: 99%

Changes in the pattern of sensitization to common contact allergens in Denmark between 1985–86 and 1997–98, with a special view to the effect of preventive strategies

Johansen

Menné

Christophersen³

et al. 2000

British Journal of Dermatology

185

132

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The objective of the present study is to describe any changes in the prevalence of sensitization to common contact allergens in patch-tested patients over a 12-year period. Attention is given to possible effects of preventive strategies introduced in Denmark regarding nickel and chromate sensitization during that period, and particular areas of concern are identified. Members of the Danish Contact Dermatitis Group collected patch-test results from consecutive eczema patients as well as information about exposures and demographic variables over a 6-month period in 1985-86. The investigation was repeated in 1997-98 in the same clinics, at the same time of year, using identical methods and patch-test substances, including nickel sulphate 5%, potassium dichromate 0.5% and fragrance mix 8%. Nickel was the most common contact allergen in both study periods, followed by the fragrance mix. In children 0-18 years of age, the frequency of nickel allergy decreased from 24.8% in the first study period to 9.2% in the second study period (P < 0. 0008). Fragrance mix allergy doubled in frequency from 4.1% in 1985-86 to 9.9% in 1997-98, an increase that affected all age groups. Contact allergy to potassium dichromate decreased significantly from 3.0% in the first period to 1.2% in the second period (P = 0. 001). The decrease was seen in both sexes and was most pronounced among those of working age. No other significant changes were found in the frequency of sensitization to common allergens over the 12-year observation period.

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“…1 Since the 1960s, MP has been used as a marker for fragrance sensitivity, as it was discovered that half of the patients with positive reactions to MP are also sensitive to one or more toilet soap perfumes and vice versa. [2][3][4] In this article, various aspects of contact allergy to MP are reviewed, including its chemical composition, the frequency of sensitization, the sensitizers, the relevance of positive reactions, the MPcontaining products causing allergic contact dermatitis, the use of restrictive diets in patients reacting to MP, and co-reactivity with other fragrance and non-fragrance materials. An attempt is made to establish the significance of positive patch test reactions to MP and the value of testing MP in the baseline series.…”

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confidence: 99%

Myroxylon pereiraeresin (balsam of Peru) – A critical review of the literature and assessment of the significance of positive patch test reactions and the usefulness of restrictive diets

Groot¹

2019

Contact Dermatitis

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In this article, contact allergy to Myroxylon pereirae resin (MP) (balsam of Peru) is reviewed. The topics presented include the uses, the chemical composition, the frequency of sensitization, the relevance of positive reactions, the MP-containing products causing allergic contact dermatitis, co-reactivity with other fragrance and nonfragrance materials, the sensitizers, the usefulness of MP as a "marker" of fragrance allergy, and the effectiveness of, and indications for, "balsam-restrictive" diets. Sensitization to MP occurs in 4% to 8% of patients routinely tested for suspected contact dermatitis. There are few adequate data on relevance. Topical pharmaceuticals were formerly, but are not today, important sources of sensitization. Cosmetics and foods or drinks are hardly ever products responsible for sensitization to MP. Positive patch test reactions in the large majority probably result from previous sensitization to MP constituents because of their presence in fragrances and fragranced products, MP thereby acting as marker (or "indicator") of fragrance allergy. However, fragrance mix I is a more sensitive marker, and the added diagnostic value of testing with MP is unknown. The allergenic ingredients of MP include isoeugenol, eugenol and cinnamyl alcohol, but there are other-largely unknown-chemicals that are responsible for contact allergy. Suggestions are given for further research to address questions thus far unanswered and to improve patient care. K E Y W O R D Sbalsam of Peru, balsam-restrictive diet, chemical composition, eugenol, cinnamyl alcohol, coniferyl benzoate, fragrance, isoeugenol, Myroxylon pereirae resin, perfume, fragrance marker, contact allergy

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Allergy to Perfumes From Toilet Soaps and Detergents in Patients With Dermatitis

Cited by 53 publications

References 9 publications

Occurrence of contact allergy and hand eczemas in hospital wet work

Occurrence of contact allergy and hand eczemas in hospital wet work

Changes in the pattern of sensitization to common contact allergens in Denmark between 1985–86 and 1997–98, with a special view to the effect of preventive strategies

Myroxylon pereiraeresin (balsam of Peru) – A critical review of the literature and assessment of the significance of positive patch test reactions and the usefulness of restrictive diets

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