Allergy to the complex salts of platinum. A review of the literature and three case reports.

Ørbæk, Palle

doi:10.5271/sjweh.2488

Cited by 26 publications

(8 citation statements)

References 10 publications

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“…In past centuries, allergic reactions were observed in refineries workers (Hunter et al1945;Orbaek 1982;Niezborala and Garnier 1996) exposed to high concentrations of Pt and included lung and skin symptoms as sneezing, wheezing, breathlessness, cough, tightness of chest, eczematous and urticarial skin lesions, and sign of mucous membrane inflammation (Health and Safety Executive 1990), which Fig. 6 Mean values and standard deviations of platinum and rhodium concentrations (lg/cm 2 ) inside full thickness damaged skin.…”

Section: Discussionmentioning

confidence: 98%

Permeation of platinum and rhodium nanoparticles through intact and damaged human skin

et al. 2015

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The aim of the study was to evaluate percutaneous penetration of platinum and rhodium nanoparticles (PtNPs: 5.8 ± 0.9 nm, RhNPs: 5.3 ± 1.9 nm) through human skin. Salts compounds of these metals are sensitizers and some also carcinogenic agents. In vitro permeation experiments were performed using Franz diffusion cells with intact and damaged skin. PtNPs and RhNPs, stabilized with polyvinylpyrrolidone, were synthesized by reduction of Na2PtCl6 and RhCl3·3H2O respectively. Suspensions with a concentration of 2.0 g/L of PtNPs and RhNPs were dispersed separately in synthetic sweat at pH 4.5 and applied as donor phases to the outer surface of the skin for 24 h. Measurements of the content of the metals in the receiving solution and in the skin were performed subsequently. Rhodium skin permeation was demonstrated through damaged skin, with a permeation flux of 0.04 ± 0.04 μg cm−2 h−1 and a lag time of 7.9 ± 1.1 h, while no traces of platinum were found in receiving solutions. Platinum and rhodium skin-analysis showed significantly higher concentrations of the metals in damaged skin. Rh and Pt applied as NPs can penetrate the skin barrier and Rh can be found in receiving solutions. These experiments pointed out the need for skin contamination prevention, since even a minor injury to the skin barrier can significantly increase penetration

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Section: Discussionmentioning

confidence: 98%

Permeation of platinum and rhodium nanoparticles through intact and damaged human skin

et al. 2015

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“…In fact, clinically relevant allergic reactions to platinum itself are a well-recognized occupational hazard for platinum miners [7,8,9]. …”

Section: Introductionmentioning

confidence: 99%

“…It has been hypothesized that the usual prolonged delay in development of platinum hypersensitivity in susceptible individuals results from extremely low concentrations of metallic platinum that may be a nonmeasurable contaminant during the process of preparing the clinically utilized platinum agents (cisplatin, carboplatin, oxaliplatin) [ 3 ]. In fact, clinically relevant allergic reactions to platinum itself are a well-recognized occupational hazard for platinum miners [ 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Hypersensitivity following Retreatment with Carboplatin a Decade after Completion of Primary Platinum-Based Chemotherapy

Williams

Markman

2009

Case Rep Oncol

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“…R eports on occupational allergy due to cytostatics are scarce and mainly concern allergic contact dermatitis and allergic contact urticaria (1,2). To our knowledge, there is no published case report on mitoxantrone‐induced allergic asthma.…”

mentioning

confidence: 99%

Occupational asthma due to mitoxantrone

Walusiak

Wittczak

Ruta

et al. 2002

Allergy

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Allergy to the complex salts of platinum. A review of the literature and three case reports.

Cited by 26 publications

References 10 publications

Permeation of platinum and rhodium nanoparticles through intact and damaged human skin

Permeation of platinum and rhodium nanoparticles through intact and damaged human skin

Hypersensitivity following Retreatment with Carboplatin a Decade after Completion of Primary Platinum-Based Chemotherapy

Occupational asthma due to mitoxantrone

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