Allergy to walnuts and hazelnuts in atopic dermatitis patients and analysis of sensitization to molecular components

Čelakovská, Jarmila; Bukač, Josef; Vaňková, R.; Salavec, M; Krejsek, Jan; Andrýs, Ctirad

doi:10.1080/09540105.2021.1874883

Cited by 5 publications

(3 citation statements)

References 41 publications

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“…Omalizumab is an anti-IgE monoclonal antibody that works by binding to the Fc region of IgE antibodies, inhibiting receptor binding on mast cells and basophils [53], preventing degranulation and allergic manifestations. It should be initiated before the OIT and continued for a few weeks after [54].…”

Section: Omalizumabmentioning

confidence: 99%

Treatment and Strategy for Food Allergies in Paediatrics

Shaikh,

Samad,

Bamer

2024

Int J Health Sci Res

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Food allergy (FA) has significantly increased in the last decade, and its diagnosis is a continuous challenge. Mild cases are often neglected or detected late, and in children, parents may not be able to accurately interpret symptoms. It is crucial to differentiate FAs from food intolerance and toxic reactions. To provide personalized management, accurate diagnosis is essential. Modern diagnostic tests, such as component diagnosis and epitope reactivity, allow for a more accurate therapeutic approach and reliable prognosis evaluation. Investigations like serum IgE, elimination diets, oral food challenges, single, blind, and double-blind tests, and skin tests are used. Anaphylaxis risk can be assessed using molecular diagnostics/component-resolved diagnosis (CRD) and a basophilic activation test (BAT). These tests allow for planned, individualized therapy based on molecular and clinical characteristics. Understanding immunological processes, diagnostics, and immunotherapies in FAs is crucial for evaluating food allergen exposure, detecting allergic responses, analyzing clinical manifestations, highlighting diagnostic options, and demonstrating appropriate therapeutic strategies. Key words: Food allergy, paediatric, basophilic activation test, component-resolved diagnosis

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Section: Omalizumabmentioning

confidence: 99%

Treatment and Strategy for Food Allergies in Paediatrics

Shaikh,

Samad,

Bamer

2024

Int J Health Sci Res

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“…Study of IgE specificity revealed an association of sensitization to molecular components of pollen allergens with food reactions in patients suffering from atopic dermatitis. In patients suffering from reactions to peanuts, hazelnuts, celery, apple and peach, a significantly higher frequency of sensitization to major pollen allergens Bet v 1, Aln g 1, Phl p 1, 2, 4, 5, 6, 11 was found ( Čelakovská et al, 2021a ; Čelakovská et al, 2021b ). Interestingly, sensitization to Bet v 1 homologues and profilins is associated with mild symptoms (pollen eating syndrome), and sensitization to LTP homologues and seed storage proteins are associated with severe reactions ( Čelakovská et al, 2021a ).…”

Section: Sensitization To Pollen Allergensmentioning

confidence: 99%

How Do Pollen Allergens Sensitize?

Guryanova

Finkina

Melnikova

et al. 2022

Front. Mol. Biosci.

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Plant pollen is one of the main sources of allergens causing allergic diseases such as allergic rhinitis and asthma. Several allergens in plant pollen are panallergens which are also present in other allergen sources. As a result, sensitized individuals may also experience food allergies. The mechanism of sensitization and development of allergic inflammation is a consequence of the interaction of allergens with a large number of molecular factors that often are acting in a complex with other compounds, for example low-molecular-mass ligands, which contribute to the induction a type 2-driven response of immune system. In this review, special attention is paid not only to properties of allergens but also to an important role of their interaction with lipids and other hydrophobic molecules in pollen sensitization. The reactions of epithelial cells lining the nasal and bronchial mucosa and of other immunocompetent cells will also be considered, in particular the mechanisms of the activation of B and T lymphocytes and the formation of allergen-specific antibody responses.

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“…Omalizumab is an anti-IgE monoclonal antibody. It works by binding to the Fc region of IgE antibodies, blocking the binding to specific receptors on mast cells and basophils [59,60,68], preventing their degranulation and therefore the appearance of allergic manifestations. Omalizumab should be initiated before the OIT and continued for a few more weeks in parallel [31,69,70].…”

Section: Omalizumabmentioning

confidence: 99%

Food Allergy a Constant Concern to the Medical World and Healthcare Providers: Practical Aspects

Sur

Armat

Duca

et al. 2021

Life

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Food allergy (FA) is a condition with a growing incidence and is a constant concern for the medical world and healthcare providers. With potential symptoms including anaphylaxis, in the event of an allergic reaction the patient’s life may well be endangered. The diagnosis of FA is a continuous challenge because mild cases tend to be ignored or diagnosed late and young children with allergies are cared for by parents, who are not always able to accurately interpret symptoms. It is very important to be able to differentiate FAs from food intolerance and toxic reactions to food. An accurate diagnosis is required to provide personalized management of an FA. More sophisticated and accurate diagnostic tests, including component diagnosis and epitope reactivity, allow the provision of a directed diagnosis, a more accurate therapeutic approach, and a useful prognostic evaluation. Tests used in current practice include the specific search for serum IgE, elimination diets, oral food challenges, single, blind, and double-blind (DBPCFC) tests, as well as skin tests. The risk of anaphylaxis can be assessed by molecular diagnostics/component-resolved diagnosis (CRD) and by conducting a basophilic activation test (BAT). These tests allow a planned, personalized treatment based on molecular and clinical profiles. CRD can determine the individual profile of allergic molecular reactivity and enable the formulation of a prognostic judgment. Our article highlights the importance of knowing the immune mechanisms, diagnostics, and immunotherapies in FAs. Starting from observing exposure to food allergens, to identifying allergic reactions, analysing the severity of clinical manifestations, noting the possibilities of diagnosis, and illustrating adequate management strategies.

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Allergy to walnuts and hazelnuts in atopic dermatitis patients and analysis of sensitization to molecular components

Cited by 5 publications

References 41 publications

Treatment and Strategy for Food Allergies in Paediatrics

Treatment and Strategy for Food Allergies in Paediatrics

How Do Pollen Allergens Sensitize?

Food Allergy a Constant Concern to the Medical World and Healthcare Providers: Practical Aspects

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