Alleviating concentration polarization: a micro three-electrode interdigitated glucose sensor based on nanoporous gold from a mild process

Fan, Guokang; Sun, Peng; Zhao, Jie; Han, Dongxue; Niu, Li; Cui, Guofeng

doi:10.1039/c8ra10459j

Cited by 7 publications

(6 citation statements)

References 55 publications

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“…The LSV curves of Au@Cu(OH) 2 /CFC, Cu(OH) 2 /CFC, Au/CFC and CFC devices in 0.1 M KOH with 1 mM glucose are shown in Figure 4A; Cu(OH) 2 /CFC shows a strong response to glucose and has a distinct anodic peak, indicating the effective catalytic activity of Cu(OH) 2 . Similarly, Au@Cu(OH) 2 /CFC shows a stronger response starting from around 0.2 V. Moreover, there is an anodic peak in Au/CFC at around 0.5 V, consistent with our previous study that nanoporous Au catalyzes glucose in the around range of 0.2 to 0.52 V [38]. In order to further study the role of gold nanoparticles in nanocomposites, the electrochemically active surface areas (ECSA) and the impedances of the composite electrodes were measured.…”

Section: Resultssupporting

confidence: 91%

“…Above all, the electrocatalytic process for glucose oxidation on the Au@Cu(OH) 2 /CFC electrode is mediated by the Cu(II)/Cu(III) and Au(0)/Au(I) redox couples, as expressed in Equations (5)–(8) [31,38,53]. During anodic scan in an alkaline medium, the Cu(OH) 2 and Au are first electrooxidized to CuOOH and Au(OH) ads active intermediates.…”

Section: Resultsmentioning

confidence: 99%

“…In our previous work, we fabricated a Pt counter electrode and an Ag/AgCl reference electrode [3,38]. In this paper, the same electrochemical method was used to fabricate the Pt/CFC and Ag/AgCl/CFC.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

A Flexible Portable Glucose Sensor Based on Hierarchical Arrays of Au@Cu(OH)2 Nanograss

Jiang

Sun

Zhao

et al. 2019

Sensors

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Flexible physiological medical devices have gradually spread to the lives of people, especially the elderly. Here, a flexible integrated sensor based on Au nanoparticle modified copper hydroxide nanograss arrays on flexible carbon fiber cloth (Au@Cu(OH)2/CFC) is fabricated by a facile electrochemical method. The sensor possesses ultrahigh sensitivity of 7.35 mA mM−1 cm−2 in the linear concentration range of 0.10 to 3.30 mM and an ultralow detection limit down to 26.97 nM. The fantastic sensing properties can be ascribed to the collective effect of the superior electrochemical catalytic activity of nanograss arrays with dramatically enhanced electrochemically active surface area as well as mass transfer ability when modified with Au and intimate contact between the active material (Au@Cu(OH)2) and current collector (CFC), concurrently supplying good conductivity for electron/ion transport during glucose biosensing. Furthermore, the device also exhibits excellent anti-interference and stability for glucose detection. Owing to the distinguished performances, the novel sensor shows extreme reliability for practical glucose testing in human serum and juice samples. Significantly, these unique properties and the soft structure of silk fabric can provide a promising structure design for a flexible micro-device and a great potential material candidate of electrochemical glucose sensor.

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Section: Resultssupporting

confidence: 91%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

A Flexible Portable Glucose Sensor Based on Hierarchical Arrays of Au@Cu(OH)2 Nanograss

Jiang

Sun

Zhao

et al. 2019

Sensors

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“…Thus, there is a large class of non-enzymatic devices based on glucose oxidation on the surface of various metals and metal oxides, such as Pt, Pd, Ag, Cu x O y [11,12,13,14,15]. Gold is one of the metals that is frequently used in constructing glucose sensors mainly because of its biocompatibility [16] and resistance to surface poisoning in both neutral and alkaline environment [17]. As substrates to immobilized catalytic metal glassy carbon [18], indium tin oxide [19], carbon nanotubes [20], titanium dioxide nanotubes [21,22] or silica with titanium and graphene layers [23] are commonly considered.…”

Section: Introductionmentioning

confidence: 99%

A Flexible Nafion Coated Enzyme‐free Glucose Sensor Based on Au‐dimpled Ti Structures

et al. 2019

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The detection of glucose at low concentrations using electrochemical sensors is of great importance due to the possibility of using different human body fluids than blood, such as e. g. urine, saliva, sweat or tears. The interest behind those biofluids is related to their utility in non‐invasive sugar determination. In this work, we present flexible, fully biocompatible electrode material based on Au nanoparticles immobilized onto titanium dimples. Au−Ti heterostructures were obtained via electrochemical anodization of titanium foil in presence of fluoride anions followed by chemical etching, magnetron sputtering of gold and subsequent thermal dewetting in continuous regime. In the last step of fabrication, electrodes were modified by permselective Nafion membrane. The selection of the best electrode material among different configurations was carried out basing on the electrochemical activity in the contact with 5 mM glucose dissolved in neutral air‐saturated 0.1 M PBS. For the 10 nm Au dewetted gold film, limit of detection of 30 μM and high sensitivity of 93 mA cm−2 mM−1 were achieved. Application of Nafion membrane caused complete inhibition of the impact of various interference species onto the glucose detection. Good selectivity and repeatability combined with the resistance to prolonged mechanical stress suggest that prepared material can be used in non‐invasive glucose sensing.

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“…To ensure the stability of the [Fe(CN) 6 ] 4+ /[Fe(CN) 6 ] 3+ cation, redox pair reactions were studied at a constant neutral pH (pH = 7 buffer). Due to the superiority of alkaline pH in the oxidation of ethanol and glucose and the trends of the modern liquid fuel cells using alkaline pH-resistant membranes, EOR and glucose sensing reactions were performed in 0.3 M KOH. − …”

Section: Resultsmentioning

confidence: 99%

Noble-Metal Nanorod Cryoaerogels with Electrocatalytically Active Surface Sites

Zámbó

Rusch

Lübkemann

et al. 2021

ACS Appl. Mater. Interfaces

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Noble-metal-based electrocatalysts usually contain small nanoparticle building blocks to ensure a high specific surface area as the scene for the surface processes. Here, we show that relatively large noble-metal nanorods are also promising candidates to build up functional macrostructures with prominent electrocatalytic activity. After optimizing and upscaling the syntheses of gold nanorods and gold bipyramid-templated silver nanorods, cryoaerogels are fabricated on a conductive substrate via flash freezing and subsequent freeze drying. The versatile cryoaerogelation technique allows the formation of macrostructures with dendritic, open-pore structure facilitating the increase of the accessible nanorod surfaces. It is demonstrated via electrochemical oxidation and stripping test experiments that noble-metal surface sites are electrochemically active in redox reactions. Furthermore, gold nanorod cryoaerogels offer a platform for redox sensing, ethanol oxidation reaction, as well as glucose sensing. Compared to their simply drop-cast and dried counterparts, the noble-metal nanorod cryoaerogels offer enhanced activity due to the open porosity of the fabricated nanostructure while maintaining structural stability.

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Alleviating concentration polarization: a micro three-electrode interdigitated glucose sensor based on nanoporous gold from a mild process

Abstract: An interdigitated three-electrode non-enzymatic glucose sensor based on nanoporous gold is achieved and presents excellent sensing performance including great sensitivity, high stability and low detective limit.

Cited by 7 publications

References 55 publications

A Flexible Portable Glucose Sensor Based on Hierarchical Arrays of Au@Cu(OH)2 Nanograss

A Flexible Portable Glucose Sensor Based on Hierarchical Arrays of Au@Cu(OH)2 Nanograss

A Flexible Nafion Coated Enzyme‐free Glucose Sensor Based on Au‐dimpled Ti Structures

Noble-Metal Nanorod Cryoaerogels with Electrocatalytically Active Surface Sites

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