Alleviating Effects of Bushen-Yizhi Formula on Ibotenic Acid-Induced Cholinergic Impairments in Rat

Hou, Xian‐Geng; Zhang, Lei; Yang, Cong; Rong, Cuiping; He, Wen-Qing; Zhang, Chunxia; Shi, Li; Su, Ruyu; Chang, Xiang; Qin, Ji-Huan; Chen, Yunbo; Xian, Shaoxiang; Wang, Qi

doi:10.1089/rej.2014.1603

Cited by 22 publications

(24 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These features demonstrate that SAMP8 is a successful dementia model. In this study, we found that BSYZ could improve the learning and memory of SAMP8 mice, which is according with our previous studies [ 9 , 10 ]. Donepezil (DON) showed the similar effect on elevating the availability of ACh in the brain, which has been documented as critical for the effective management of Alzheimer's disease and used as a positive control in ameliorating memory and cognitive impairments [ 29 , 30 ].…”

Section: Discussionsupporting

confidence: 91%

“…In a multi-center, randomized, double-blind, controlled clinical trial, patients with dementia show significant increase in mini-mental state examination (MMSE) scores after treatment of BSYZ. In animal experiments, BSYZ could ameliorate the spatial memory and object memory impairments through cholinergic pathways, NGF signaling and anti-apoptosis in ibotenic acid (IBO) induced cognitive dysfunction [ 9 , 10 ]. However, the neuroprotective mechanism of BSYZ is still obscure.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Bushen-Yizhi formula ameliorates cognitive dysfunction through SIRT1/ER stress pathway in SAMP8 mice

Zhang

Lin

et al. 2017

Oncotarget

Self Cite

View full text Add to dashboard Cite

The Chinese formula Bushen-Yizhi (BSYZ) has been reported to ameliorate cognitive dysfunction. However the mechanism is still unclear. In this study, we employ an aging model, SAMP8 mice, to explore whether BSYZ could protect dementia through SIRT1/endoplasmic reticulum (ER) stress pathway. Morris water maze and the fearing condition test results show that oral administration of BSYZ (1.46 g/kg/d, 2.92 g/kg/d and 5.84 g/kg/d) and donepezil (3 mg/kg/d) shorten the escape latency, increase the crossing times of the original position of the platform and the time spent in the target quadrant, and increase the freezing time. BSYZ decreases the activity of acetylcholinesterase (AChE), and increases the activity of choline acetyltransferase (ChAT) and the concentration of acetylcholine (Ach) in both hippocampus and cortex. In addition, western blot results (Bcl-2, Bax and Caspase-3) and TUNEL staining show that BSYZ prevents neuron from apoptosis, and elevates the expression of neurotrophic factors, including nerve growth factor (NGF), postsynapticdensity 95 (PSD95) and synaptophysin (SYN), in both hippocampus and cortex. BSYZ also increases the protein expression of SIRT1 and alleviates ER stress-associated proteins (PERK, IRE-1α, eIF-2α, BIP, PDI and CHOP). These results indicate that the neuroprotective mechanism of BSYZ might be related with SIRT1/ER stress pathway.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Bushen-Yizhi formula ameliorates cognitive dysfunction through SIRT1/ER stress pathway in SAMP8 mice

Zhang

Lin

et al. 2017

Oncotarget

Self Cite

View full text Add to dashboard Cite

show abstract

“…Detailed information was presented in Table 1 . The extraction process and the qualitatively analysis of BSYZ formula were performed in accordance with our previous study [ 25 ].…”

Section: Methodsmentioning

confidence: 99%

Bushen‐Yizhi Formula Alleviates Neuroinflammation via Inhibiting NLRP3 Inflammasome Activation in a Mouse Model of Parkinson’s Disease

Wei

et al. 2018

Evidence-Based Complementary and Alternative Medicine

Self Cite

View full text Add to dashboard Cite

Parkinson's disease (PD), the second most common neurodegenerative disease, is characterized by the progressive loss of dopaminergic neurons in the substantia nigra. Although the molecular mechanisms underlying dopaminergic neuronal degeneration in PD remain unclear, neuroinflammation is considered as the vital mediator in the pathogenesis and progression of PD. Bushen-Yizhi Formula (BSYZ), a traditional Chinese medicine, has been demonstrated to exert antineuroinflammation in our previous studies. However, it remains unclear whether BSYZ is effective for PD. Here, we sought to assess the neuroprotective effects and explore the underlying mechanisms of BSYZ in a 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine- (MPTP-) induced mouse model of PD. Our results indicate that BSYZ significantly alleviates the motor impairments and dopaminergic neuron degeneration of MPTP-treated mice. Furthermore, BSYZ remarkably attenuates microglia activation, inhibits NLPR3 activation, and decreases the levels of inflammatory cytokines in MPTP-induced mouse brain. Also, BSYZ inhibits NLRP3 activation and interleukin-1β production of the 1-methyl-4-phenyl-pyridinium (MPP+) stimulated BV-2 microglia cells. Taken together, our results indicate that BSYZ alleviates MPTP-induced neuroinflammation probably via inhibiting NLRP3 inflammasome activation in microglia. Collectively, BSYZ may be a potential therapeutic agent for PD and the related neurodegeneration diseases.

show abstract

“…8,9 Zhuang Jing Decoction (ZJD), a traditional Chinese medicine (TCM) formula consisting of Talinum crassifolium, Gynostemma pentaphylla, Euonymus fortunei, and Curculigo capitulata root, has been reported to be effective in the treatment of perimenopausal women syndrome, which demonstrated that the ZJD may have certain effects on antiaging. 10 Moreover, it has been reported that some of the components had beneficial effects on learning and memory ability.…”

Section: Introductionmentioning

confidence: 99%

Effect of Zhuang Jing Decoction on Learning and Memory Ability in Aging Rats

Cai

Cen-han

et al. 2016

Rejuvenation Research

Self Cite

View full text Add to dashboard Cite

With the average life span of humans on the rise, aging in the world has drawn considerable attentions. The monoamine neurotransmitters and neurotrophic factors in brain areas are involved in learning and memory processes and are an essential part of normal synaptic neurotransmission and plasticity. In the present study, the effect of Zhuang Jing Decoction (ZJD) on the learning and memory ability in aging rats was examined in vivo using Morris water maze. Furthermore, the levels of monoamine neurotransmitters and neurotrophic factors in brain were detected by high-performance liquid chromatography with a fluorescence detector and enzymelinked immunosorbent assay, respectively. These data showed that oral administration with ZJD at the dose of 30 g$kg -1 exerted an improved effect on learning and memory ability in aging rats. The results revealed that ZJD could effectively adjust the monoamine neurotransmitters and neurotrophic factors, restore the balance of the level of monoamine neurotransmitters and neurotrophic factors in brain, and finally attenuate the degeneration of learning and memory ability. These findings suggested that ZJD might be a potential agent as cognitive-enhancing drug in improving learning and memory ability. It may exert through regulating the levels of monoamine neurotransmitters and neurotrophic factors in brain, which demonstrated that ZJD had certain antiaging effects.

show abstract

Alleviating Effects of Bushen-Yizhi Formula on Ibotenic Acid-Induced Cholinergic Impairments in Rat

Cited by 22 publications

References 50 publications

Bushen-Yizhi formula ameliorates cognitive dysfunction through SIRT1/ER stress pathway in SAMP8 mice

Bushen-Yizhi formula ameliorates cognitive dysfunction through SIRT1/ER stress pathway in SAMP8 mice

Bushen‐Yizhi Formula Alleviates Neuroinflammation via Inhibiting NLRP3 Inflammasome Activation in a Mouse Model of Parkinson’s Disease

Effect of Zhuang Jing Decoction on Learning and Memory Ability in Aging Rats

Contact Info

Product

Resources

About