Alleviating Neuropathic Pain Mechanical Allodynia by Increasing Cdh1 in the Anterior Cingulate Cortex

Tan, Wei; Yao, Wenlong; Hu, Rong; Lv, Yan; Wan, Li; Zhang, Chuan‐Han; Zhu, Chang

doi:10.1186/s12990-015-0058-6

Cited by 16 publications

(11 citation statements)

References 42 publications

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“…Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer (OMIM ID: 192090). In addition, studies have shown that CDH1 was expressed highly in the mammalian neurons, and it has the function of regulating synaptic differentiation and transmission [ 39 , 40 ]. CDH1 plays an important role in the development of central nervous system disease [ 40 , 41 ], we deduce the gene CDH1 is correlated with AD.…”

Section: Resultsmentioning

confidence: 99%

Genome-wide haplotype association study identify TNFRSF1A, CASP7, LRP1B, CDH1 and TG genes associated with Alzheimer's disease in Caribbean Hispanic individuals

Shang

Zhang

et al. 2015

Oncotarget

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Alzheimer's disease (AD) is an acquired disorder of cognitive and behavioral impairment. It is considered to be caused by variety of factors, such as age, environment and genetic factors. In order to identify the genetic affect factors of AD, we carried out a bioinformatic approach which combined genome-wide haplotype-based association study with gene prioritization. The raw SNP genotypes data was downloaded from GEO database (GSE33528). It contains 615 AD patients and 560 controls of Caribbean Hispanic individuals. Firstly, we identified the linkage disequilibrium (LD) haplotype blocks and performed genome-wide haplotype association study to screen significant haplotypes that were associated with AD. Then we mapped these significant haplotypes to genes and obtained candidate genes set for AD. At last, we prioritized AD candidate genes based on their similarity with 36 known AD genes, so as to identify AD related genes. The results showed that 141 haplotypes on 134 LD blocks were significantly associated with AD (P<1E-4), and these significant haplotypes were mapped to 132 AD candidate genes. After prioritizing these candidate genes, we found seven AD related genes: APOE, APOC1, TNFRSF1A, LRP1B, CDH1, TG and CASP7. Among these genes, APOE and APOC1 are known AD risk genes. For the other five genes TNFRSF1A, CDH1, CASP7, LRP1B and TG, this is the first genetic association study which showed the significant association between these five genes and AD susceptibility in Caribbean Hispanic individuals. We believe that our findings can provide a new perspective to understand the genetic affect factors of AD.

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Section: Resultsmentioning

confidence: 99%

Genome-wide haplotype association study identify TNFRSF1A, CASP7, LRP1B, CDH1 and TG genes associated with Alzheimer's disease in Caribbean Hispanic individuals

Shang

Zhang

et al. 2015

Oncotarget

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“…The pathology of NeP in patients with low back pain has been attributed to nerve tissue damage generated by mechanical compression or inflammation of the nerve root due to degenerative disc disease [11]. Results from studies in animal models have also suggested that factors such as notch signaling activation [26], transient receptor potential ankyrin 1 (TRPA1) [27], and Cdh1 [28] are involved in the pathogenesis of NeP.…”

Section: Discussionmentioning

confidence: 99%

Neuropathic pain in patients with rotator cuff tears

Karasugi

Ide

Kitamura

et al. 2016

BMC Musculoskelet Disord

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BackgroundRecent studies have confirmed the existence of neuropathic pain (NeP) components in patients with musculoskeletal disorders. However, the presence of NeP in patients with rotator cuff tears has not been investigated thus far. Therefore, we studied the prevalence of NeP and the prognostic factors for NeP in patients with rotator cuff tears.MethodsData were collected from 110 patients with rotator cuff tears, diagnosed by physical examination and magnetic resonance imaging, who attended an outpatient clinic between August 2013 and August 2014. The measured parameters included visual analog scale (VAS) pain scores, painDETECT questionnaire (PDQ) responses, a physical examination, and magnetic resonance imaging. To evaluate the factors associated with NeP, we performed a two-stage analysis. For univariate analysis, we used the Mann-Whitney U test. For multivariate analysis, forward stepwise regression was performed using factors that demonstrated statistical significance in the univariate analysis.ResultsPatients were classified into three groups according to their PDQ score: an NeP group (n = 12; 10.9 %), possible NeP group (n = 33; 30.0 %), and a nociceptive pain (NoP) group (n = 65; 59.1 %). In the univariate analysis between the NeP group and NoP group, NeP was affected by sex (p = 0.034), VAS score (average pain during the past 4 weeks; p = 0.013), and positive Neer and Hawkins impingement signs (p = 0.039). In the multivariate analysis, VAS score (p = 0.031) was an independent prognostic factor for NeP.ConclusionsUsing the PDQ, we found that 10.9 % of patients with rotator cuff tears may have NeP. The VAS score (average pain during the past 4 weeks) was a prognostic factor for NeP. Clinicians should remain vigilant for heterogeneous etiologies of pain in patients with rotator cuff tears.

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“…; Tan et al . ). On the basis of ensuring the validity of experimental results, all efforts were made to reduce the number of animals used in our experiments and to minimize any possible suffering by the animals.…”

Section: Methodsmentioning

confidence: 97%

Involvement of chemokine CXCL11 in the development of morphine tolerance in rats with cancer‐induced bone pain

Guo

Peng

Xiong

et al. 2017

Journal of Neurochemistry

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Morphine is viewed as one of the classical treatments for intractable pain, but its role is limited by side effects, including analgesic tolerance. A few chemokines have been reported to be engaged in the mechanisms of morphine tolerance. However, the exact roles of CXC chemokine 11 (CXCL11) in chronic morphine tolerance remain unknown. In this study, Walker 256 mammary gland carcinoma cells were inoculated into the tibia of rats to provoke cancer-induced bone pain. Then, morphine was intrathecally administered twice daily for seven consecutive days to induce drug tolerance. We found that the level of CXCL11 in lumbar spinal cord was increased during the development of morphine tolerance in cancer-induced bone pain rats. Meanwhile, CXCL11 was co-localized with markers of astrocytes and neurons in the spinal cord. Inhibition of CXCL11 by neutralizing antibodies could remarkably attenuate the degree of morphine tolerance and decrease the activation of astrocytes. Moreover, blocking astrocyte activation by d, l-Fluorocitric acid could distinctly alleviate morphine tolerance and reduce the expression of CXCL11. Finally, morphine stimulation could induce the release of CXCL11 by cultured astrocytes and neurons in vitro. In summary, our results provide evidence that spinal CXCL11 plays a powerful modulatory role in the development of morphine tolerance through cross-talking between astrocytes and neurons. Read the Review series "Pain".

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Alleviating Neuropathic Pain Mechanical Allodynia by Increasing Cdh1 in the Anterior Cingulate Cortex

Cited by 16 publications

References 42 publications

Genome-wide haplotype association study identify TNFRSF1A, CASP7, LRP1B, CDH1 and TG genes associated with Alzheimer's disease in Caribbean Hispanic individuals

Genome-wide haplotype association study identify TNFRSF1A, CASP7, LRP1B, CDH1 and TG genes associated with Alzheimer's disease in Caribbean Hispanic individuals

Neuropathic pain in patients with rotator cuff tears

Involvement of chemokine CXCL11 in the development of morphine tolerance in rats with cancer‐induced bone pain

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