Alleviation of Experimental Diabetes in Man by Administration of Reduced Glutathione (GSH): Metabolic Implications

Conn, Jerome W.; Louis, Lawrence H.; Johnston, Margaret Woodwell

doi:10.1126/science.109.2829.279

Cited by 40 publications

(6 citation statements)

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“…These findings may serve to renew speculation of a connection between nucleo-protein metabolism and diabetes [25]. It has been suggested that uric acid [26] or a substance resembling uric acid might have an alloxan-like action on the B-cells of the islets and so produce diabetes [27]. However, others failed to confirm such a diabetogenic action for uric acid [28].…”

Section: Discussionmentioning

confidence: 90%

Diabetes, prediabetes and uricaemia

1976

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Three diabetes surveys carried out at two yearly intervals on 10000 men aged 40 years and over have enabled us to compare four groups of subjects with regard to their serum uric acid level in relation to carbohydrate metabolism. Prediabetics, that is, persons who screened negative at previous surveys and subsequently developed diabetes, had a higher mean uric acid level than normals (p less than 0.001). Their uric acid level was considerably higher than in diabetics, who had a mean value lower than normals (up to p less than 0.001). Men, without diabetes, but having an abnormal GTT were found to have a mean value higher than the normals at each survey.

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Section: Discussionmentioning

confidence: 90%

Diabetes, prediabetes and uricaemia

1976

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“…Recent evidence has indicated that the adrenal cortical hormones affect the ability of the renal tubule to reabsorb glucose and thereby "lower the renal threshold" for these substances. 24 The present studies have provided further indication of the importance of such "renal factors".…”

Section: Commentmentioning

confidence: 88%

The Effects Of Stressful Life Situations on the Concentration of Blood Glucose In Diabetic and Nondiabetic Humans

Hinkle

Wolf

1952

Diabetes

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The blood glucose concentration is the resultant of a dynamic equilibrium between the amount of glucose taken up by the tissues and that supplied to the blood by the liver. Under ordinary circumstances this concentration is maintained with relative constancy in the healthy individual, but fluctuates much more widely in the person with diabetes mellitus. In all individuals the ingestion of carbohydrate food tends to raise the blood glucose level, and physical exercise tends to depress it. The administration of the hormones which are concerned with the regulation of carbohydrate metabolism (such as epinephrine, insulin, adrenal cortical steroids, and pituitary growth hormone) may also cause changes in the circulating glucose. Physical stresses such as infections and trauma likewise affect the blood glucose regulation, apparently because they lead to the elaboration of these hormones as a part of the adaptive processes of the organism. The function of the endocrine glands which regulate carbohydrate metabolism may be altered also by stimuli arising in the external environment in the form of events or situations which are evaluated by the individual as threatening, and which therefore initiate adaptive responses mediated through the central nervous system. It has long been felt that stimuli of this sort might also lead to changes in the level of circulating glucose; and in fact experimental evidence has indicated that hyperglycemia can be produced in diabetic persons during psychiatric interviews. 1 The present study was undertaken in order to examine the effects of stressful events and situations upon the level of glucose in the circulating blood of diabetic and nondiabetic individuals.

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“…12 These metabolic changes are not merely parallel to, but also due to, the drop in GSH level, since administration of GSH to human subjects with experimental ACTH-diabetes has been shown to alleviate the metabolic symptoms. 6 This finding, however, has not been borne out with rats whose diabetes was cortisone-produced. 16 The drop in GSH levels noted in these cited cases approximates that following parachute jumping.…”

Section: Discussionmentioning

confidence: 89%

Glutathione Metabolism in Men under Psychological Stress

Persky

1954

Psychosomatic Medicine

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Alleviation of Experimental Diabetes in Man by Administration of Reduced Glutathione (GSH): Metabolic Implications

Cited by 40 publications

References 1 publication

Diabetes, prediabetes and uricaemia

Diabetes, prediabetes and uricaemia

The Effects Of Stressful Life Situations on the Concentration of Blood Glucose In Diabetic and Nondiabetic Humans

Glutathione Metabolism in Men under Psychological Stress

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