Alleviation of iron induced oxidative stress by the grape fruit flavanone naringin in vitro

Jagetia, Ganesh Chandra; Reddy, Tiyagura Koti

doi:10.1016/j.cbi.2011.02.009

Cited by 44 publications

(43 citation statements)

References 58 publications

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“…32,[63][64][65] Naringin has also been reported to protect against iron and bleomycin-induced lipid peroxidation in earlier studies. 40,41,43 Similarly L-glutamine has been also reported to protect against the DPX-induced lipid peroxidation. 61 The exact mechanism by which naringin attenuated the DOXinduced oxidative stress is not clearly understood.…”

Section: Discussionmentioning

confidence: 99%

“…The DOX has been reported to produce greater amount of free radicals when free iron is available and chelation of iron by naringin may be another mechanism of alleviation of DOXinduced oxidative stress, since naringin chelates iron. 41 The naringin supplementation has been reported to up regulate mRNA expression of superoxide dismutase, catalase and glutathione peroxidase genes. 75 The transcriptional activation of NF-κB and COX-II by DOX increases oxidative stress and their transcriptional suppression by naringin has been may have also reduced the DOX-induced oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

“…35,38,39 It has been found to be anti-inflammatory, antidiabetic, antifibortic, antiosteoporotic, antidyslipidemic and protected against lipodystrophy and iron induced toxicity. [40][41][42][43][44] Naringin may also have protective effects on cognition and oxidative damage. 45 Naringin reduced cell viability and cell proliferation by arresting the cell cycle at the G1 phase in 5637 cells and inhibited cyclin D1/CDK4 and cyclin E-CDK2 complexes by the increased expression of p21WAF1 and activation of Ras/Raf/ERK.…”

Section: Introductionmentioning

confidence: 99%

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Treatment of Mice with Naringin Alleviates the Doxorubicin-Induced Oxidative Stress in the Liver of Swiss Albino Mice

Ch¹,

Jagetia²,

Lalrinengi³

2017

MOJAP

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Doxorubicin a photosensitive antibiotic is frequently used to treat various malignancies in clinics; however, doxorubicin is also taken up by the normal cells of the body leading to increased oxidative stress and subsequently DNA damage and dysfunction in the cells. The agents which can reduce the adverse effect of doxorubicin will of great value. The present study has attempted to study the effect of naringin a citrus flavonoid on the doxorubicininduced oxidative stress in mice liver. The mice were administered with 0, 1, 5 or 10mg/ kg body weight of doxorubicin and treated with 10mg/kg body weight of naringin before or after doxorubicin treatment. The glutathione concentration and lipid peroxidation and activities of glutathione-s-transferase, catalase and super oxide dismutase were studied at 0.5, 1, 2 and 4h post-treatment in the mouse liver. The doxorubicin increased the lipid peroxidation in a dose dependent manner at all the post treatment times. Conversely, it attenuated the activities of glutathione-s-transferase, catalase and super oxide dismutase in dose dependent fashion and time dependent manner. A similar effect was observed for glutathione concentration. Treatment of mice with naringin before or after doxorubicin treatment elevated all the antioxidants and reduced the doxorubicin -induced lipid peroxidation. The effect of naringin pretreatment was more effective when compared to its post treatment. The naringin was very effective in reducing the oxidative stress induced by doxorubicin as indicated by the elevated levels of glutathione concentration, glutathiones-transferase, catalase and super oxide dismutase. The pretreatment of naringin was better than its post treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Treatment of Mice with Naringin Alleviates the Doxorubicin-Induced Oxidative Stress in the Liver of Swiss Albino Mice

Ch¹,

Jagetia²,

Lalrinengi³

2017

MOJAP

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“…Naringin has been reported to scavenge free radicals and possess metal chelating, and antioxidant properties [23][24][25][26][27]. It has been found to protect against Parkinson's disease in preclinical studies [28].…”

Section: Biochemistry and Molecular Biology Journal Issn 2471-8084mentioning

confidence: 99%

“…Naringin has been reported to protect against the DOX-induced lipid peroxidation in mouse liver and heart [18]. Naringin also reduced radiation or iron induced lipid peroxidation in vivo and in vitro [27,32,61]. It has been reported to alleviate DOX induced lipid peroxidation in mice and rat liver and heart [47,48].…”

Section: Biochemistry and Molecular Biology Journal Issn 2471-8084mentioning

confidence: 99%

The Citrus Flavanone Naringin Enhances Antioxidant Status in the Albino Rat Liver Treated with Doxorubicin

Ch¹,

Jagetia²,

Lalnuntluangi³

2016

Biochem Mol Biol J

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Sources of Natural Antioxidants and Their Activities

Charles¹

2012

Antioxidant Properties of Spices, Herbs and Other Sources

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Alleviation of iron induced oxidative stress by the grape fruit flavanone naringin in vitro

Cited by 44 publications

References 58 publications

Treatment of Mice with Naringin Alleviates the Doxorubicin-Induced Oxidative Stress in the Liver of Swiss Albino Mice

Treatment of Mice with Naringin Alleviates the Doxorubicin-Induced Oxidative Stress in the Liver of Swiss Albino Mice

The Citrus Flavanone Naringin Enhances Antioxidant Status in the Albino Rat Liver Treated with Doxorubicin

Sources of Natural Antioxidants and Their Activities

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