Alleviation of Metabolic Syndrome with Dietary Egg White Protein

Shirouchi, Bungo; Matsuoka, Ryosuke

doi:10.5650/jos.ess19084

Cited by 14 publications

(9 citation statements)

References 29 publications

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“…Eggs are a major source of dietary cholesterol in addition to many other nutrients such as high-quality proteins, vitamins, minerals and saturated and unsaturated fatty acids. 27 The inverse association between egg consumption and MS may be attributed to other components of egg rather than cholesterol, which might have favourable effects on inhibiting the development of MS. Shirouchi and Matsuoka 16 suggested that dietary egg white protein and lactic-fermented egg white (an easily consumable form of egg white) could both prevent or alleviate the development of MS. A randomised control study comparing the whole-egg group with the yolk-free substitute group in terms of MS reported that the whole egg had positive effects on the plasma carotenoid status and enrichment of HDL and LDL with lutein and zeaxanthin; these factors may influence the development of MS-related degenerative conditions. 17 Similar results were reported by other randomised control studies.…”

Section: Discussionmentioning

confidence: 99%

“… 14 15 Similarly, the association between the other components of eggs besides cholesterol (eg, egg white protein, lutein or zeaxanthin) and MS has not been fully investigated. 16 17 To the best of our knowledge, there are two studies that examined the relationship between egg consumption and MS, which produced varying results. 18 19 In view of this, comprehensive research on the association between dietary egg consumption and MS could provide valuable insights for the development and update of dietary guidelines.…”

Section: Introductionmentioning

confidence: 99%

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Association between egg consumption and metabolic syndrome in Chinese population: a cross-sectional study

Wang

Shen

et al. 2021

BMJ Open

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ObjectivesMetabolic syndrome (MS) comprises a constellation of symptoms that include abdominal obesity, hypertension, hyperglycaemia and dyslipidaemia. Dietary intake is a crucial environmental risk factor for MS, but the exact association between MS and egg consumption, which accounts for more than half of the daily total cholesterol intake in Chinese population, has not been previously studied. The aim of this study was to examine the correlation between dietary egg consumption and the prevalence of MS in the context of a large population.DesignA cross-sectional study.SettingsOur study was conducted in a health examination centre in China.ParticipantsParticipants who aged ≥40 years and received routine physical examinations were included for analyses.Main outcome measuresMS was diagnosed in accordance with the clinical diagnosis criteria specified in the American Heart Association Guidelines. Egg consumption was assessed by a validated semi-quantitative food frequency questionnaire.ResultsA total of 11 529 participants (46.2% women) were included in the present study. On the basis of multivariable logistic regression analysis, egg consumption was negatively associated with the prevalence of MS after adjusting for dietary energy intake (OR=0.84, 95% CI 0.76 to 0.93, p value for trend=0.001). The above findings did not change with further adjustment for other potential confounders: model 2 was further adjusted for age, body mass index and sex (based on model 1) and model 3 was further adjusted for education level, physical activity level, smoking status, alcohol use status, dietary fat intake, dietary fibre intake and nutritional supplementation (based on model 2). Consistent results were obtained from the analysis in the female subgroup but not in male subjects.ConclusionsA higher level of egg consumption was associated with a lower prevalence of MS in our study participants, and particularly in female subjects.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association between egg consumption and metabolic syndrome in Chinese population: a cross-sectional study

Wang

Shen

et al. 2021

BMJ Open

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“…The global prevalence of MetS ranges from 10% to 84%, mostly affecting developed countries [ 4 ]. For example, a recent significant health concern in Japan is that half of the males and one-fifth of females aged 40 to 74 years suffer from MetS or pre-MetS [ 5 ]. MetS increases the risk of sudden cardiac death by 70% [ 6 ], the risk of cardiovascular events by twofold, and the risk of Type 2 diabetes mellitus (T 2 DM) by fivefold [ 3 ], thus raising healthcare costs [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…Single or combination use of medications, regular physical activities, and/or dietary management are imperative in managing risk factors of MetS [ 5 , 7 , 8 ]. However, numerous adverse effects and the high cost of medication treatment [ 9 ], failing to meet the minimal recommended level of physical exercise [ 8 ], hard-to-follow diet regime [ 5 ], and requiring strong mind control to change the mindset and control thoughts [ 9 ] were reported. Therefore, cost-effective approaches on using bioactive compounds [ 10 ], nutraceuticals and supplements on prevention and treatment of various chronic diseases such as T 2 DM emerged.…”

Section: Introductionmentioning

confidence: 99%

Astaxanthin Influence on Health Outcomes of Adults at Risk of Metabolic Syndrome: A Systematic Review and Meta-Analysis

et al. 2022

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The use of medication is effective in managing metabolic syndrome (MetS), but side effects have led to increased attention on using nutraceuticals and supplements. Astaxanthin shows positive effects in reducing the risk of MetS, but results from individual studies are inconclusive. This systematic review summarizes the latest evidence of astaxanthin in adults with risk factors of MetS. A systematic search of English and Chinese randomized controlled trials in 14 electronic databases from inception to 30 June 2021 was performed. Two reviewers independently screened the titles and abstracts, and conducted full-text review, quality appraisal, and extraction of data. Risk of bias was assessed by PEDro. A total of 7 studies met the inclusion criteria with 321 participants. Six studies were rated to have excellent methodological quality, while the remaining one was rated at good. Results show marginal effects of astaxanthin on reduction in total cholesterol and systolic blood pressure, and a significant attenuating effect on low-density lipoprotein cholesterol. Further robust evidence is needed to examine the effects of astaxanthin in adults at risk of MetS.

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“…Eggs provide essential nutrients including protein, carotenoids, arginine and folate, while its high level of cholesterol has been associated with the increased risk of diabetes from laboratory tests involving impaired insulin secretion (4) . Also, the experiment reported egg hydrolysate inhibited the intestinal αglucosidase to delay carbohydrate absorption (5) , but another study showed that daily consumption of lactic-fermented egg white reduced serum cholesterol in men and alleviated the metabolic syndrome (6) . A meta-analysis of twelve cohorts studies including 219 979 participants showed a 39 % (95 % CI 21 %, 60 %) higher risk of diabetes mellitus comparing the highest with the lowest egg consumption in US studies but not in non-US studies (7) .…”

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confidence: 99%

Higher egg consumption associated with increased risk of diabetes in Chinese adults – China Health and Nutrition Survey

Wang

Shi

2020

Br J Nutr

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The association between egg consumption and diabetes is inconclusive. We aimed to examine the association between long-term egg consumption and its trajectory with diabetes in Chinese adults. A total of 8 545 adults aged ≥ 18 years old who attended the China Health and Nutrition Survey from 1991 to 2009 were included in this analysis. Egg consumption at each survey was assessed by a three-day 24-hour recall and weighed food record methods. The consumption trajectories of egg were modelled with the latent class group approach. Diabetes was diagnosed based on fasting blood glucose in 2009. Logistic regression was used to examine the association. The mean age of the study population was 50.9 (SD 15.1) years. 11.1% had diabetes in 2009. Egg consumption nearly doubled in 2009 from 16 g/day in 1991. Compared with the first quartile of egg consumption (0-9.0 g/day), the adjusted OR (95% CI) of diabetes for the second (9.1-20.6 g/day), third (20.7-37.5 g/day), and fourth (≥ 37.6 g/day) quartiles were 1.29 (95% CI 1.03, 1.62), 1.37 (95% CI 1.09, 1.72), and 1.25 (95% CI 1.04, 1.64), respectively (P for trend = 0.029). Three trajectory groups of egg consumption were identified. Compared with Group 1 (30.7%, low baseline intake and slight increase), both Group 2 (62.2%, medium baseline intake and increase) and Group 3 (7.1%, high baseline intake and decrease) were associated with an increased odds ratio (OR) for diabetes. The results suggested that higher egg consumption was positively associated with the risk of diabetes in Chinese adults.

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Alleviation of Metabolic Syndrome with Dietary Egg White Protein

Cited by 14 publications

References 29 publications

Association between egg consumption and metabolic syndrome in Chinese population: a cross-sectional study

Association between egg consumption and metabolic syndrome in Chinese population: a cross-sectional study

Astaxanthin Influence on Health Outcomes of Adults at Risk of Metabolic Syndrome: A Systematic Review and Meta-Analysis

Higher egg consumption associated with increased risk of diabetes in Chinese adults – China Health and Nutrition Survey

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