Allicin can suppress the activity of vascular endothelial cells probably by regulating JAK2/STAT3 pathway

Sun, Hongyan; Feng, Xinmin; Wang, Jingcheng; Cai, Jun

doi:10.1007/s11010-020-03919-z

Cited by 8 publications

(6 citation statements)

References 27 publications

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“…In our literature review, Allicin was also identified as an inhibitor of wound healing [85] and subsequently revealed modulation of metabolism via JAK2/STAT3 [225]. Allicin did inhibit scratch closure in both HV and keloid fibroblasts in a dose dependent fashion (Fig 5A and 5B).…”

Section: Allicin Altered Metabolism and Scratch Closurementioning

confidence: 85%

“…However, our results suggest that caffeine may be less ideal due to an increased potency inhibiting wound healing in healthy cell line FB than those from keloids (Fig 2E ) and failed to impact the hyperinflammatory state of keloid line FB (Fig 3F). Allicin, a sulfur containing metabolite extracted from garlic, has also been used to mitigate murine models of fibrotic disorders like keloid scars and pulmonary fibrosis [85,225,228]. Allicin may present the most promising candidate for clinical trials given it appeared more potent against keloid FB than healthy cells in its OxPhos inhibition (Fig 5F ), cell toxicity (Figs 5A and S2A), and IL-6 inhibition (Fig 5K).…”

Section: Plos Onementioning

confidence: 99%

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Therapeutic candidates for keloid scars identified by qualitative review of scratch assay research for wound healing

et al. 2021

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The scratch assay is an in vitro technique used to analyze cell migration, proliferation, and cell-to-cell interaction. In the assay, cells are grown to confluence and then ‘scratched’ with a sterile instrument. For the cells in the leading edge, the resulting polarity induces migration and proliferation in attempt to ‘heal’ the modeled wound. Keloid scars are known to have an accelerated wound closure phenotype in the scratch assay, representing an overactivation of wound healing. We performed a qualitative review of the recent literature searching for inhibitors of scratch assay activity that were already available in topical formulations under the hypothesis that such compounds may offer therapeutic potential in keloid treatment. Although several shortcomings in the scratch assay literature were identified, caffeine and allicin successfully inhibited the scratch assay closure and inflammatory abnormalities in the commercially available keloid fibroblast cell line. Caffeine and allicin also impacted ATP production in keloid cells, most notably with inhibition of non-mitochondrial oxygen consumption. The traditional Chinese medicine, shikonin, was also successful in inhibiting scratch closure but displayed less dramatic impacts on metabolism. Together, our results partially summarize the strengths and limitations of current scratch assay literature and suggest clinical assessment of the therapeutic potential for these identified compounds against keloid scars may be warranted.

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Section: Allicin Altered Metabolism and Scratch Closurementioning

confidence: 85%

Section: Plos Onementioning

confidence: 99%

Therapeutic candidates for keloid scars identified by qualitative review of scratch assay research for wound healing

et al. 2021

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“…According to Liu et al, allicin protected against vascular and cardiac remodeling in spontaneously hypertensive rats by suppressing the activation of the inhibitory calcium/calmodulin-dependent protein kinase type II (CaMK II)/NF-κB pathway . Allicin was also reported to inhibit vascular endothelial cell (VEC) activity by modulating the Janus kinase (JAK 2)/STAT 3 pathways, demonstrating the role of allicin in inhibiting angiogenesis and preventing epidural hypertrophic scars . In summary, allicin could be used as a cardioprotective agent by increasing the levels of antioxidant enzymes (SOD3, GPX1, CAT) and decreasing the levels of inflammatory factors (TNF-α, IL-1β, and IL-6), inhibiting the activation of the CaMK II/NF-κB pathway, and regulating SREBP2 protein expressions.…”

Section: Biological Functionsmentioning

confidence: 99%

Bioavailability, Health Benefits, and Delivery Systems of Allicin: A Review

Deng,

Ho,

Lan

et al. 2023

J. Agric. Food Chem.

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Garlic has been used worldwide as a spice due to its pungent taste and flavor-enhancing properties. As a main biologically active component of the freshly crushed garlic extracts, allicin (diallyl thiosulfinate) is converted from alliin by alliinase upon damaging the garlic clove, which has been reported to have many potent beneficial biological functions. In this work, allicin formation, stability, bioavailability, and metabolism process are examined and summarized. The biological functions of allicin and potential underlying mechanisms are reviewed and discussed, including antioxidation, anti-inflammation, antidiabetic, cardioprotective, antineurodegenerative, antitumor, and antiobesity effects. Novel delivery systems of allicin with enhanced stability, encapsulation efficiency, and bioavailability are also evaluated, such as nanoparticles, gels, liposomes, and micelles. This study could provide a comprehensive understanding of the physiochemical properties and health benefits of allicin, with great potential for further applications in the food and nutraceutical industries.

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“…One of the pro-survival factor Bcl2 mainly decides the fate of cells. According to recent findings, allicin can significantly reduce the expression level of Bcl12 in diabetic rats resulting in the reversal of myocardial apoptosis [ 58 ].…”

Section: Biosynthesis Properties and Action Mechanism Of Allicinmentioning

confidence: 99%

Allicin, an Antioxidant and Neuroprotective Agent, Ameliorates Cognitive Impairment

et al. 2021

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Allicin (diallylthiosulfinate) is a defense molecule produced by cellular contents of garlic (Allium sativum L.). On tissue damage, the non-proteinogenic amino acid alliin (S-allylcysteine sulfoxide) is converted to allicin in an enzyme-mediated process catalysed by alliinase. Allicin is hydrophobic in nature, can efficiently cross the cellular membranes and behaves as a reactive sulfur species (RSS) inside the cells. It is physiologically active molecule with the ability to oxidise the thiol groups of glutathione and between cysteine residues in proteins. Allicin has shown anticancer, antimicrobial, antioxidant properties and also serves as an efficient therapeutic agent against cardiovascular diseases. In this context, the present review describes allicin as an antioxidant, and neuroprotective molecule that can ameliorate the cognitive abilities in case of neurodegenerative and neuropsychological disorders. As an antioxidant, allicin fights the reactive oxygen species (ROS) by downregulation of NOX (NADPH oxidizing) enzymes, it can directly interact to reduce the cellular levels of different types of ROS produced by a variety of peroxidases. Most of the neuroprotective actions of allicin are mediated via redox-dependent pathways. Allicin inhibits neuroinflammation by suppressing the ROS production, inhibition of TLR4/MyD88/NF-κB, P38 and JNK pathways. As an inhibitor of cholinesterase and (AChE) and butyrylcholinesterase (BuChE) it can be applied to manage the Alzheimer’s disease, helps to maintain the balance of neurotransmitters in case of autism spectrum disorder (ASD) and attention deficit hyperactive syndrome (ADHD). In case of acute traumatic spinal cord injury (SCI) allicin protects neuron damage by regulating inflammation, apoptosis and promoting the expression levels of Nrf2 (nuclear factor erythroid 2-related factor 2). Metal induced neurodegeneration can also be attenuated and cognitive abilities of patients suffering from neurological diseases can be ameliorates by allicin administration.

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Allicin can suppress the activity of vascular endothelial cells probably by regulating JAK2/STAT3 pathway

Cited by 8 publications

References 27 publications

Therapeutic candidates for keloid scars identified by qualitative review of scratch assay research for wound healing

Therapeutic candidates for keloid scars identified by qualitative review of scratch assay research for wound healing

Bioavailability, Health Benefits, and Delivery Systems of Allicin: A Review

Allicin, an Antioxidant and Neuroprotective Agent, Ameliorates Cognitive Impairment

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