Alliin protects against inflammatory bowel disease by preserving the gene expression in colonic epithelial cells rather than altering gut microbiota

Li, Xuanwei; Luo, Jianming; Zhang, Cheng; Liu, Liu; Ou, Shiyi; Zhang, Guangwen; Peng, Xichun

doi:10.1016/j.jff.2019.05.048

Cited by 4 publications

(2 citation statements)

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“…The abundance of Actinobacteria, Proteobacteria, and Verrucomicrobia was increased in the DSS group, suggesting that these bacteria are highly related to UC [48]. We also observed a decrease in the genera of Ruminococcaceae and Lachnospiraceae and an increase in those of Bacteroides, which have been shown to be involved in enteritis in IBD models [48,54]. In addition, the relative abundance of Parabacteroides was decreased and that of Alistipes was increased in the OKG group.…”

Section: Discussionmentioning

confidence: 52%

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Effect of Ornithine α-Ketoglutarate on Intestinal Microbiota and Serum Inflammatory Cytokines in Dextran Sulfate Sodium Induced Colitis

Wang

Tian

et al. 2023

Nutrients

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Ornithine α-ketoglutarate (OKG), a nutritional compound, is an amino acid salt with anti-oxidative and anti-inflammatory effects on humans and animals. Ulcerative colitis (UC), as an inflammatory bowel disease (IBD), leads to chronic intestinal inflammatory dysfunction. This study evaluated the optimal dosage of OKG in healthy mice. Then, a mouse model of acute colitis was established using dextran sodium sulfate (DSS), and the preventive effect of OKG on DSS-induced colitis in mice was explored through analysis of serum inflammatory cytokines and fecal microbiota. Initially, the mice were randomly divided into a control group, a group given a low dose of OKG (LOKG: 0.5%), a group given a medium dose of OKG (MOKG: 1%), and a group given a high dose of OKG (HOKG: 1.5%); they remained in these groups for the entire 14-day experimental period. Our results demonstrated that 1% OKG supplementation increased body weight, serum growth hormone (GH), insulin (INS), alkaline phosphatase (ALP), Tyr, and His and decreased urea nitrogen (BUN), NH3L, and Ile. Then, a 2 × 2 factor design was used for a total of 40 mice, with diet (a standard diet or a 1% OKG diet) and challenge (4% DSS or not) as the main factors. During days 14 to 21, the DSS mice were administered 4% DSS to induce colitis. The results revealed that OKG alleviated weight loss and reversed the increases in colonic histological damage induced by DSS. OKG also increased serum IL-10 secretion. Moreover, OKG enhanced the abundance of Firmicutes and decreased that of Bacteriodetes at the phylum level and particularly enhanced the abundance of Alistipes and reduced that of Parabacterioides at the genus level. Our results indicated that OKG promotes growth performance and hormone secretion and regulates serum biochemical indicators and amino acid concentrations. Furthermore, 1% OKG supplementation prevents DSS-induced colitis in mice via altering microbial compositions and reducing the secretion of inflammatory cytokines in serum.

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Section: Discussionmentioning

confidence: 52%

“…Gut microbes play a vital role in defense against pathogen invasion [20,[51][52][53], and microbial profiles are closely correlated with host immunity and inflammation [46,54]. The disruption of host-gut microbial homeostasis may lead to inflammation [45].…”

Section: Discussionmentioning

confidence: 99%