Allium hooshidaryae (Alliaceae); Chemical compositions, biological and ethnomedicine uses

Ghoran, Salar Hafez; Rahimi, Hero; Kazemi, Abdolhassan; Scognamiglio, Monica; Naderian, Moslem; Iraji, Aida; Bordbar, Firouzeh

doi:10.1016/j.jep.2021.113918

Cited by 15 publications

(1 citation statement)

References 49 publications

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“…In Anatolia Allium cepa and A. sativum have been used as a protection from infections, sunstroke, hypertension, rheumatism, antihelmintic, for headache and as an analgesic [14]. Iranian folk medicine used Allium species for treatment of atherosclerosis, rheumatism, tuberculosis, gastric and lung diseases [12]. Allium species are well known for Georgian traditional medicine as an antifungal, antiseptic and antibacterial remedy [1,2].…”

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Pharmacological Assessment of Constituents of Species Allium Saxatile and Allium Ponticum Growing in Georgia

JGERENAIA¹,

SULAKVELIDZE²,

NOVIKOVA³

et al. 2022

jecm

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The present study aimed to estimate pharmacological potency of products from some Allium species -Allium saxatile and Allium ponticum, growing in Georgia. Analgesic, anti-inflammatory and gastroprotective activity of total extracts and fractions from was evaluated using accepted in vivo models: hot-plate, carrageenan induced oedema and ethanol induced gastric ulcer, respectively. The results of the experiments have revealed valuable effects of the total extracts and fractions obtained from A. saxatile and A. ponticum. In particular, A. saxatile total extract demonstrated moderately ascending prolonged analgesic activity (70.3%), whereas total extract of A.ponticum exhibited rapid, high, but shortlasting effect (105%). Same tendency was noticed when fractions were studied. Similarly, A. saxatile total extract and its fractions appeared more effective (63.5%), than one obtained from A.ponticum (32.7%) in carrageenan induced paw oedema model. In ethanol induced gastric ulcer model only A. saxatile appeared to effectively reduce ulcer index (UI) by 44%, when A. ponticum extract, oppositely, increased ulcer index JECM 2022/4 10 (UI). Summarizing the results, it can be concluded that the study revealed A.saxatile and A.ponticum as a promising raw of bioactive compounds for drug development.

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confidence: 99%