Allo-Antigens and Antigenic Factors of Human Leukocytes

The Major Histocompatibility Complex in Man

“…The extreme frequency of cross-reactions between the various allelic molecules ofeaeh HLA locus is well known. Two interpretations that are not mutually exclusive are possible: the similarity in the structure ofthe allelic epitopes (see Colombani et al [21]) or the existence of determinants common to two molecules but different from the epitopes; determinants which 1, and Ivanyi [22], have called 'antigenic factors' (also known as supertypical antigens or public antigens).…”

Reactivity of Monoclonal Antibodies Specific for H‐2 Antigenic Determinants with Cells of Wild Mice

“…This conclusion is in accordance with the absorption results as well as with the observed high frequency of cross-reactions of "monospecific" alloantisera when tested against wild mouse populations (Klein 1970, Ivanyi & Mickova 1972. Incidentally, this conclusion is not really new; Ivanyi & Dausset (1966) arrived at similar conclusions for the HLA system based on the findings that sets of operational monospecific antisera revealed only minor discrepancies when tested on a population sample in the context in which they were generated but major discrepancies when tested on alien populations.…”

Reactivity of Anti‐HLA Sera against Mouse Lymphocytes*

“…It is generally accepted that on both molecules there are major and minor determinants. The major determinant would correspond to the narrow HLA specificity and to the private H-2 specificity; the minor determinant(s) would explain certain cross-reactions in the HLA system (antigenic factor) (Ivanyi & Dausset 1966, Legrand & Dausset 1973 and would correspond to some public H-2 specificities. It is then possible that certain HLA-H-2 cross-reactions may be due to similarities between major determinants.…”