Allogeneic Transplantation of the Radial Side of the Hand in the Rhesus Monkey

Hovius, Steven E.R.; Stevens, Hieronymus P; Nierop, P. W. M. Van; Rating, W.; Strik, R. Van; Meulen, Jacques C. van der

doi:10.1097/00006534-199204000-00020

Cited by 61 publications

(16 citation statements)

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“…Orthotopic models in small and large animals have been designed to address these questions. Technical success has been reported in orthotopic mouse hind limb transplantation [23,24] and motor and sensory nerve functions have been positively evaluated in orthotopic limb transplants in both rodents and NHPs [14,15,22]. Nonetheless, measuring functional recovery is a challenge and various strategies have been attempted.…”

Section: Heterotopic Vs Orthotopicmentioning

confidence: 99%

Preclinical Models in Vascularized Composite Allotransplantation

2015

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Vascularized composite allotransplantation (VCA) has the potential to reconstruct any non-visceral tissue defect, using like for like tissue, delivering optimal form and function. Over 150 VCA transplants have been performed worldwide; however, this treatment remains experimental. Things systematically tried in the clinic should follow thorough science and tested in a model that allows predicting as possible the safety of the procedure. This is generally the function of animal experimentation. Advantages of preclinical models include greater control of bias, of subject numbers and of variables compared to clinical trials. Limitations include differences between species in anatomy and physiology as well as ethical, logistical and technical constraints. Multiple models have been described; however, no single model is ideal in all areas. This paper reviews historical perspectives, current models and future direction in VCA research.

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Section: Heterotopic Vs Orthotopicmentioning

confidence: 99%

Preclinical Models in Vascularized Composite Allotransplantation

2015

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“…[17][18][19][20] The one thing that these early experiences had in common were the primitive forms of immunosuppression used. In the clinical case performed in Ecuador, azathioprine and hydrocortisone were used, resulting in complete limb rejection at 2 weeks posttransplant.…”

Section: Do the Immunosuppressive Drug Regimens Currently Being Used mentioning

confidence: 99%

Hand transplantation: Comparisons and observations of the first four clinical cases

Francois¹,

Breidenbach

Maldonado³

et al. 2000

Microsurgery

168

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Twenty, 15, and 8 months after the first four successful human hand transplant procedures were performed in Lyon (France), Louisville (U.S.), and Guangzhou (China), the transplant teams convened in Louisville, Kentucky, to share their experiences at the Second International Symposium on Composite Tissue Allotransplantation. This article presents reconstructive and immunological data from these landmark procedures in tabular format, in an attempt to answer some key questions about early outcomes of clinical hand transplantation. On the basis of these data, the initial outcomes of the first four hand transplants are encouraging and warrant proceeding with additional hand transplantations.

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“…Egerseki and Hovics and colleagues have described their experience with primate hand transplantation. 45,46 Both groups have described neuromuscular recovery in longstanding survivors. In addition, Hovius observed that episodes of allograft rejection in the radial hand allograft were associated with a measurable decrease in sensation in the hand.…”

Section: Nerve Function In Composite Tissue Allograftsmentioning

confidence: 99%

Peripheral nerve and neuromuscular allotransplantation: Current status

Bain

2000

Microsurgery

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Allogeneic Transplantation of the Radial Side of the Hand in the Rhesus Monkey

Cited by 61 publications

References 0 publications

Preclinical Models in Vascularized Composite Allotransplantation

Preclinical Models in Vascularized Composite Allotransplantation

Hand transplantation: Comparisons and observations of the first four clinical cases

Peripheral nerve and neuromuscular allotransplantation: Current status

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