Allogeneic versus autologous blood during abdominal aortic aneurysm surgery

Spark, J.I.; Chetter, Ian; Kester, R. C.; Scott, D. J. A.

doi:10.1016/s1078-5884(97)80128-1

Cited by 46 publications

(42 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Five randomized controlled trials compared cell salvage to control in abdominal vascular surgical procedures. 8,[11][12][13][14] Two additional trials were excluded because allocation did not make use of randomization but rather alternately assigned patients to either cell salvage or no cell salvage. 11,14 The three remaining trials, made use of sealed opaque envelopes as a means of concealment of randomization.…”

Section: Data Extraction and Synthesismentioning

confidence: 99%

“…11,14 The three remaining trials, made use of sealed opaque envelopes as a means of concealment of randomization. 8,12,13 None of these studies made use of blinding. It would have been technically difficult if not impossible to mask cell salvage from the anesthesiologist and surgeon.…”

Section: Data Extraction and Synthesismentioning

confidence: 99%

“…8, 13 Clagett and colleagues 8 demonstrated that cell salvage did not reduce the proportion of patients exposed to allogeneic blood (RR = 0.89, 95% CI from 0.63 to 1.27). Results reported by Spark and colleagues 13 were in the opposite direction. The investigators observed a significant decrease in exposure to red cells favouring cell salvage (RR = 0.14, 95% CI from 0.05 to 0.39).…”

Section: Data Extraction and Synthesismentioning

confidence: 99%

See 2 more Smart Citations

Cell salvage does not minimize perioperative allogeneic blood transfusion in abdominal vascular surgery: a systematic review

Alvarez

Fergusson

Neilipovitz

et al. 2004

Can J Anesth/J Can Anesth

View full text Add to dashboard Cite

P Pu ur rp po os se e: : To determine whether the use of cell salvage reduces the proportion of patients receiving at least one unit of allogeneic packed red blood cells during the perioperative period of an elective vascular surgery.S So ou ur rc ce e: : We identified all relevant articles through the combined use of electronic searches of the MEDLINE and EMBASE databases, the Cochrane library as well as hand searching of all randomized clinical trials and review articles. The electronic search included articles published between 1966 and April 2001. The search included textword searches using "autotransfusion," "cell salvage," "device," or Medical Subject Headings "autologous blood transfusion" or a "randomized controlled trials" filter. P Pr ri in nc ci ip pa al l f fi in nd di in ng gs s: : Five randomized controlled trials (RCT) were identified involving cell salvage and vascular surgeries. In infra renal abdominal aortic aneurysm surgery the risk ratio (the risk of receiving at least one unit of allogeneic red cells) was 0.37 [95% confidence intervals (CI) of 0.06 to 2.36]. In elective aorto-femoral bypass surgery the risk ratio was 0.97 (95% CI of 0.66 to 1.42). The pooled risk ratio for cell salvage in vascular surgery was 0.67 (95% CI of 0.35 to 1.28).C Co on nc cl lu us si io on n: : Cell salvage, a commonly used technique to recover red cells from the operative field, has been the subject of several studies in vascular surgery. There is insufficient evidence to recommend the routine use of cell salvage in elective abdominal aortic aneurysm and aorto-femoral bypass surgeries. A large RCT would elucidate whether cell salvage is effective as a blood conservation technique. de 0,97 (IC de 95 % de 0,66 à 1,42). Le risque commun en chirurgie vasculaire était de 0,67 (IC de 95 % de 0,35 à 1,28 Objectif Source : Les articles pertinents ont été repérés par des recherches électroniques combinées dans MEDLINE et EMBASE, la bibliothèque Cochrane et une recherche manuelle des essais cliniques randomisés et des exposés de synthèse. La recherche électronique comprend des articles publiés entre 1966 et avril 2001 à partir des termes «autotransfusion», «cell salvage», «device» ou de mots clés du domaine médical comme «autologous blood transfusion» ou d'un filtre sur les «randomized controlled trials». Constatations principales : Nous avons trouvé cinq études randomisées et contrôlées (ERC

show abstract

Section: Data Extraction and Synthesismentioning

confidence: 99%

Section: Data Extraction and Synthesismentioning

confidence: 99%

Section: Data Extraction and Synthesismentioning

confidence: 99%

See 1 more Smart Citation

Cell salvage does not minimize perioperative allogeneic blood transfusion in abdominal vascular surgery: a systematic review

Alvarez

Fergusson

Neilipovitz

et al. 2004

Can J Anesth/J Can Anesth

View full text Add to dashboard Cite

show abstract

“…However, there was a significant reduction in mortality (0.47, 0.23 to 0.99) in favour of filtered products in the patients undergoing gastrointestinal surgery. Because this difference in mortality between 23 (non-filtered) v 11 patients (filtered) (8% v 4%) could have been caused by imbalanced randomisation with respect to age, sex, duration of surgery, number of blood transfusions, or type of surgery, we have described the gastrointestinal group in more detail in table 3.…”

Section: Primary End Pointsmentioning

confidence: 99%

“…[1][2][3][4][5][6][7][8] Although blood products have never been safer with respect to transmission of infectious diseases, patients who receive blood transfusions can still develop immunological reactions. Antibodies to leucocytes received during transfusions can cause febrile reactions which can be prevented by removal of leucocytes from the blood product.…”

Section: Introductionmentioning

confidence: 99%

Effects of Transfusion with Red Cells Filtered to Remove Leucocytes: Randomised Controlled Trial in Patients Undergoing Major Surgery

2004

The Journal of the American Association of Gynecologic Laparosc

View full text Add to dashboard Cite

Objective To compare postoperative complications in patients undergoing major surgery who received non-filtered or filtered red blood cell transfusions. Design Prospective, randomised, double blinded trial. Setting 19 hospitals throughout the Netherlands (three university; 10 clinical; six general). Participants 1051 evaluable patients: 79 patients with ruptured aneurysm, 412 patients undergoing elective surgery for aneurysm, and 560 undergoing gastrointestinal surgery. Interventions The non-filtered products had the buffy coat removed and were plasma reduced. The filtered products had the buffy coat removed, were plasma reduced, and filtered before storage to remove leucocytes. Main outcome measures Mortality and duration of stay in intensive care. Secondary end points were occurrence of multi-organ failure, infections, and length of hospital stay. Results No significant differences were found in mortality (odds ratio for filtered v non-filtered 0.80, 95% confidence interval 0.53 to 1.21) and in mean stay in intensive care ( − 0.4 day, − 1.6 to 0.6 day). In the filtered group the mean length of hospital stay was 2.4 days shorter ( − 4.8 to 0.0 day; P = 0.050) and the incidence of multi-organ failure was 30% lower (odds ratio 0.70, 0.49 to 1.00; P = 0.050). There were no differences in rates of infection (0.98, 0.73 to 1.32). Conclusion The use of filtered transfusions in some types of major surgery may reduce the length of hospital stay and the incidence of postoperative multi-organ failure.

show abstract

Intraoperative Autotransfusion in Abdominal Aortic Aneurysm Surgery

Takagi¹

2007

Arch Surg

View full text Add to dashboard Cite

Allogeneic versus autologous blood during abdominal aortic aneurysm surgery

Abstract: Cell salvage autologous blood can safely replace, or at least decrease, exposure to homologous blood transfusion, with a reduction in the mean hospital stay.

Cited by 46 publications

References 23 publications

Cell salvage does not minimize perioperative allogeneic blood transfusion in abdominal vascular surgery: a systematic review

Cell salvage does not minimize perioperative allogeneic blood transfusion in abdominal vascular surgery: a systematic review

Effects of Transfusion with Red Cells Filtered to Remove Leucocytes: Randomised Controlled Trial in Patients Undergoing Major Surgery

Intraoperative Autotransfusion in Abdominal Aortic Aneurysm Surgery

Contact Info

Product

Resources

About