Allograft Tympanoplasty

Rompaey, Vincent Van; Farr, Matthew R. B.; Hamans, Evert; Mudry, Albert; Heyning, Paul Van de

doi:10.1097/mao.0b013e31826bf16d

Cited by 14 publications

(2 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Foreign body inflammatory response and consequent prosthesis extrusion have an important negative impact on the long-term outcomes of the OPL [14]. On the contrary, it has been observed that extrusion does not occur when biological materials are used [21]. For this reason, many authors advocate the possible inflammatory reaction, caused by the direct contact between the titanium prosthesis and the tympanic membrane, claiming cartilage interposition should be protective [22].…”

Section: Discussionmentioning

confidence: 99%

Titanium Biohybrid Middle Ear Prostheses: A Preliminary In Vitro Study

Mosconi,

Carlotto,

Caliogna

et al. 2023

JFB

View full text Add to dashboard Cite

Ossiculoplasty is a surgical operation performed to restore auditory transmission through the reconstruction of the ossicular chain using prosthetics. Tissue bioengineering has assumed a pivotal role in implementing alternatives to conventional ossicular middle ear replacement prostheses, to overcome extrusion while preserving acoustic properties. This in vitro study aims to explore, for the first time in current literature, the feasibility of a biohybrid middle ear prosthesis, composed of titanium surrounded by a bone extracellular matrix as bio-coating. We have hereby studied the adhesion and proliferation of human adipose-derived mesenchymal stem cells (hASC) on titanium scaffolds in vitro. Moreover, we identified the osteogenic differentiation of hASC using an immunofluorescence assay to analyze osteoblasts’ gene expression profiles (Alp, Runx2, Col1a1, Osx, and Bglap), and we counted the presence of collagen as a marker of hASC’s ability to secrete an extracellular matrix. We utilized scanning electron microscopy to evaluate the presence of an extracellular matrix on the scaffolds. Our preliminary data demonstrated the titanium’s ability to support human adipose-derived mesenchymal stem cell colonization, proliferation, and osteoblastic differentiation, in order to obtain a biohybrid device. Our experience seems encouraging; thus, we advocate for further in vivo research to corroborate our results regarding bone transplantation.

show abstract

Section: Discussionmentioning

confidence: 99%

Titanium Biohybrid Middle Ear Prostheses: A Preliminary In Vitro Study

Mosconi,

Carlotto,

Caliogna

et al. 2023

JFB

View full text Add to dashboard Cite

show abstract

“…Tympanoplasty is a common otologic surgery that aims to reconstruct the perforated TM. Since the introduction of tympanoplasty surgery in 1952, several graft materials have been used to reconstruct the perforated TM [3–5]. The unique and complex structure of the TM makes it difficult to find an ideal grafting material that provides both excellent acoustic transmission and the rigid mechanical properties needed for long term stability in diseased ears.…”

Section: Introductionmentioning

confidence: 99%

Repair of subtotal tympanic membrane perforations: A temporal bone study of several tympanoplasty materials

2019

View full text Add to dashboard Cite

The aim of this project was to investigate the effects of different types of graft material, and different remaining segments of the native TM on its motion. In twelve human temporal bones, controlled TM perforations were made to simulate three different conditions. (1) Central perforation leaving both annular and umbo rims of native TM. (2) Central perforation leaving only a malleal rim of native TM. (3) Central perforation leaving only an annular rim of native TM. Five different graft materials (1) perichondrium (2) silastic (3) thin cartilage (4) thick cartilage (5) Lotriderm® cream were used to reconstruct each perforation condition. Umbo and stapes vibrations to acoustic stimuli from 250 to 6349 Hz were measured using a scanning laser Doppler vibrometer. Results showed that at low frequencies: in the Two Rims condition, all grafting materials except thick cartilage and Lotriderm cream showed no significant difference in umbo velocity from the Normal TM, while only Lotriderm cream showed a significant decrease in stapes velocity; in the Malleal Rim condition, all materials showed a significant decrease in both umbo and stapes velocities; in the Annular Rim condition, all grafting materials except Lotriderm and perichondrium showed no significant difference from the Normal TM in stapes velocity. Umbo data might not be reliable in some conditions because of coverage by the graft. At middle and high frequencies: all materials showed a significant difference from the Normal TM in both umbo and stapes velocities for all perforation conditions except in the Annular Rim condition, in which silastic and perichondrium showed no significant difference from the Normal TM at umbo velocity in the middle frequencies. In the low frequencies, the choice of repair material does not seem to have a large effect on sound transfer. Our data also suggests that the annular rim could be important for low frequency sound transfer.

show abstract

Ossicular replacement prostheses from banked bone with ergonomic and functional geometry

et al. 2016

View full text Add to dashboard Cite

This study shows the fabrication of innovative ossicular replacement prostheses (ORPs) based on banked cortical bone using computer numerically controlled ultraprecision micromilling, as a substantial improvement of "second generation" ORPs. Our aim is to combine optimal middle ear compatibility and surgical manageability in a single device, by releasing off-the-shelf homograft ORPs provided with the appealing features of synthetic ORPs, such as lightness, safety, measurement accuracy, surface decoration, and geometric plasticity. The new total ORP prototype was 13.1 ± 0.1 mg, leading to 81% weight reduction with respect to the previous model. Surface motifs of the head plate were applied to prevent slipping and migration after surgery, as shown by finite element modeling analysis. In addition, bone ORPs were provided with holed head plates to facilitate their surgical positioning while reducing their mass. A comparative measurement of acoustic responses of bone against synthetic partial ORPs in the 250-8000 Hz frequency range demonstrated their superior behavior. This study showed that banked compact bone can be optimally manufactured, eventually enabling the fabrication of light, standardized, and highly performant ORPs. The new bone ORPs may represent the ideal combination of biocompatibility and technology which can ultimately accomplish unmet otosurgical needs. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2495-2506, 2017.

show abstract

Allograft Tympanoplasty

Abstract: Whether allograft tympanoplasty will have a place in the future of otology remains to be seen, but an understanding of the history of this technique is essential in evaluating its merit.

Cited by 14 publications

References 74 publications

Titanium Biohybrid Middle Ear Prostheses: A Preliminary In Vitro Study

Titanium Biohybrid Middle Ear Prostheses: A Preliminary In Vitro Study

Repair of subtotal tympanic membrane perforations: A temporal bone study of several tympanoplasty materials

Ossicular replacement prostheses from banked bone with ergonomic and functional geometry

Contact Info

Product

Resources

About