How can we tell whether an agreement feature will end up as a prefix, a suffix, or a combination of exponents? Research on Afroasiatic languages has identified a number of asymmetries which can be found between prefixes and suffixes. This short review considers these asymmetries, points out three cross-Semitic generalizations, and outlines the possible sources for them. Four kinds of theoretical explanations are evaluated: Syntactic, Morphological, Morphotactic and Morphophonological.