Allotypes of Complement Components in Man

An immunoblotting technique for complement C6 typing: Three new variants

“…Table 2 demonstrates the C6 allele frequencies of three Japanese populations so far studied. We previously reported in the Tokyo population that C6*B is commoner than C6*A, contrary to many other populations (Hobart and Lachmann, 1976;Kfihnl and Kreckel, 1980;Kunstmann et al, 1980;Olving et al, 1980;Ranford et al, 1982), and that C6"B2 was the third common allele in Japanese (Tokunaga et al, 1983). These have been confirmed by the surveys on western Japanese (Nishimukai et al, 1985) and northeastern Japanese (present study) 9 Moreover, six rare variants (A3, A21, M1, M2, B3, and B4) were observed in the Tokyo population and four (91,Mll,B4,and B5) in the present study.…”

“…The polymorphism has been shown to be controlled by codominant alleles at a single autosomal locus. Two predominant alleles, C6*A and C6*B, and many rare variants have been described so far (Hobart and Lachmann, 1976;Mauff et al, 1980;Ranford et al, 1982;Tokunaga et at., 1983). The reason why such a number of variants occur at C6 locus is still unknown.…”

Genetic polymorphisms of human complement components BF and C2 in Korean: Population and association studies

“…Genetic polymorphism of human C2 protein was first described by Hobart and Lachmann (1976), Alper (1976), and Meo et al (1977) using ;soelectric focusing followed by specific hemolytic overlay. C2 polymorphism is controlled by codominant alleles at a single structural locus.…”

Genetic control of the eighth component of complement.

“…There appears also to be extensive polymorphism in C4 (5-7), but there is disagreement with respect to the number and nature of alleles, the number of genetic loci, and the ability to detect heterozygotes. Less extensive inherited structural variation occurs in C2 (8,9), C7 (9,10), and properdin factor D (9).…”