Alloxan Diabetes in Rabbits. Production of Hypercholesterolemia, Hyperlipemia and Adrenal Cortical Lesions

Kendall, Forrest E.; Meyer, Walter J.; Lewis, Liese; Victor, Joseph

doi:10.3181/00379727-60-15133

Cited by 94 publications

(10 citation statements)

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“…Adrenal cortical lesions have also been described in rab bits (91). Adrenalectomy in rats with alloxan diabetes reduced hyper glycemia and glycosuria (92).…”

Section: Alloxan Diabetesmentioning

confidence: 97%

Carbohydrate Metabolism

Cori

1946

Annu. Rev. Biochem.

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A complete survey of papers published in 1945 was made difficult by the inaccessibility of many European journals. With few excep tions, a review. of the carbohydrate metabolism of microorganisms could not be included because of the limitation of space.The increasing importance of isotopes as a tool in biochemistry is reflected in the rapid advances which have been made in inter mediary carbohydrate metabolism with this technique. Isotopes have also been used to great advantage in demonstrating reversibility of enzymatic reactions, particularly those involving carbon. dioxide fixa tion or phosphate transfer. The common metabolic pool for carbon fragments derived from the three principal foodstuffs and their com mon oxidative pathway has made it impossible to discuss the inter mediary metabolism of carbohydrates without some reference to that • of the other foodstuffs.The gap which often exists between results obtained in experi ments on the whole animal and on isolated enzyme systems is being bridged to some extent. Here again the use of isotopes plays a lead ing role, but a unified picture will not emerge until the mechanism of the regulatory effect of hormones on enzyme systems is more clearly understood.The usual abbreviations have been used: ATP and ADP for adenosinetriphosphate and adenosinediphosphate ; TPN and DPN for tri-and diphosphopyridine nucleotide; and P for phosphate.

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“…Adrenal cortical lesions have also been described in rab bits (91). Adrenalectomy in rats with alloxan diabetes reduced hyper glycemia and glycosuria (92).…”

Section: Alloxan Diabetesmentioning

confidence: 97%

Carbohydrate Metabolism

Cori

1946

Annu. Rev. Biochem.

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“…Effect of administration of alloxan: The transient hyperlipemia which occurs in some animals shortly after administration of alloxan (20,21) was studied. In contrast to the sera of cholesterolfed rabbits, the hyperlipemic sera of animals acutely toxic from alloxan failed to inhibit streptolysin 0 even at a serum cholesterol concentration of 675 mg. per cent.…”

mentioning

confidence: 99%

The Use of Hemolysin Inhibition in the Study of Experimental And Clinical Hyperlipemia: THE NON-SPECIFIC INHIBITION OF STREPTOLYSIN O BY SERUM LIPOPROTEINS1

Stollerman¹

1954

J. Clin. Invest.

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“…The general problems of alloxan diabetes have been the subject of a number of papers : the dwarfing effect of alloxan diabetes in rats (273), the changes in plasma and liver phosphates in diabetic coma produced by alloxan in rats (274), and the relation between the dosage of alloxan and the severity of diabetes to the develop ment of hyperlipemia in rabbits (275).…”

Section: Lukensmentioning

confidence: 99%

Metabolic Functions of the Endocrine Glands

Lukens¹

1947

Annu. Rev. Physiol.

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Alloxan Diabetes in Rabbits. Production of Hypercholesterolemia, Hyperlipemia and Adrenal Cortical Lesions

Cited by 94 publications

References 0 publications

Carbohydrate Metabolism

Carbohydrate Metabolism

The Use of Hemolysin Inhibition in the Study of Experimental And Clinical Hyperlipemia: THE NON-SPECIFIC INHIBITION OF STREPTOLYSIN O BY SERUM LIPOPROTEINS1

Metabolic Functions of the Endocrine Glands

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