Allyl-functionalized hybrid silica monoliths

Abstract

A hybrid organosilica monolith was synthesized containing an allyl functionality. This provided a viable platform for producing silica-based, chromatographic, monolithic columns with the stationary phase bonded through a surface silicon-carbon bond rather than a conventional siloxane bond.

Recent advances in preparation and application of hybrid organic‐silica monolithic capillary columns

“…As shown in Fig. 3, trialkoxysilanes with hydrophobic organic moieties, such as N-octadecyldimethyl [3-(trimethoxy silyl)propyl]ammonium chloride [23], n-octyltriethoxysilane (C8-TES) [32][33][34][35], phenyltriethoxysilane (PTES) [36][37][38], propyltrimethoxysilane (C3-TMS) [39], MTMS [40][41][42][43][44], and other trialkoxysilanes with active organic functionalities, such as aminopropyl triethoxysilane (APTES) [45][46][47][48][49], N-(␤-aminoethyl)-␥-aminopropyl-triethoxysilane [50], N-(␤-aminoethyl)-␥-aminopropylmethyldimethoxysilane [51], 3-chloropropyltrimethoxysilane [52], 3-mercaptopropyltrime thoxysilane (MPTMS) [53], N-trimethoxysilylpropyl-N,N,Ntrimethylammonium chloride [54], allyl-trimethoxysilane [ 55,56], and vinyltrimethoxysilane (VTMS) [57] have been selected as coprecursors with tetraalkoxysilanes, TMOS, or TEOS. Additionally, bridged silanes such as 1,4-bis(triethoxysily1)benzene [58] have also been used for preparation of hybrid monoliths.…”

Facile preparation of a stable and functionalizable hybrid monolith via ring-opening polymerization for capillary liquid chromatography

“…Thus, raw monoliths with high robustness, tailorability and column efficiency become a key point. Organic-inorganic hybrid monolith is an ideal alternative, which combines the merits but overcoming some inherent drawbacks of organic polymer-based monolith and silica-based monolith, such as the easy fabrication, wide pH range tolerance, high mechanical stability and permeability [17,18]. However, the multi-steps as well as the sensitivity of preparation conditions for fabrication of hybrid monoliths by using conventional sol-gel approach make the reproducibility unsatisfying [19][20][21].…”

Protein Analysis Using a Combination of an Online Monolithic Trypsin Immobilized Enzyme Reactor and Collisionally-Activated Dissociation/Electron Transfer Dissociation Dual Tandem Mass Spectrometry

“…To overcome these weaknesses, a hybrid organic-inorganic silica monolith was developed, and this material was used for trypsin immobilization. [62][63][64][65] Furthermore, in recent years, a microfluidic device including a trypsin-immobilized bioreactor channel is implemented in a commercial mass spectrometer, which improved the analysis speed and reproducibility of proteome analyses.…”