Almost Missed It! Photo-contact Allergy to Octocrylene in a Ketoprofen-sensitized Subject

Aerts, Olivier; Goossens, An; An, Bervoets; Lambert, Julien

doi:10.1097/der.0000000000000156

Cited by 13 publications

(17 citation statements)

References 4 publications

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“…Scientific literature also includes several case reports, positive photopatch test studies and reviews on photoallergic reactions attributed to octocrylene …”

Section: Cutaneous Effectsmentioning

confidence: 99%

“…showed a decreasing trend in photocontact allergy attributed to octocrylene from 2014 to 2017, which could not be explained by a restricted use of topical ketoprofen at a European level, as allergy to ketoprofen is still high in their study. Aerts et al . hypothesized that the presence of sensitizing impurities in some commercial batches of octocrylene could be the real allergen.…”

Section: Cutaneous Effectsmentioning

confidence: 99%

“…hypothesized that the presence of sensitizing impurities in some commercial batches of octocrylene could be the real allergen. The authors also suggested that recent commercial patch tests, more purified than before, might produce false negative reactions and underestimate the prevalence of photoallergy cases …”

Section: Cutaneous Effectsmentioning

confidence: 99%

“…Scientific literature also includes several case reports, positive photopatch test studies and reviews on photoallergic reactions attributed to octocrylene. 16,[23][24][25][26][27][28][29][30][31][32][33][34] Contrary to contact allergy, photoallergic contact dermatitis to octocrylene is much more frequent in adults than in children, in whom very few cases have been reported. 23 For instance, in the European photopatch test cited above, photocontact allergy to octocrylene was reported in 4% of 1031 adult patients patchtested for suspected photoallergic contact dermatitis.…”

Section: Sensitization and Photosensitizationmentioning

confidence: 99%

“…The recent study of Romita et al 31 showed a decreasing trend in photocontact allergy attributed to octocrylene from 2014 to 2017, which could not be explained by a restricted use of topical ketoprofen at a European level, as allergy to ketoprofen is still high in their study. Aerts et al 25 hypothesized that the presence of sensitizing impurities in some commercial batches of octocrylene could be the real allergen. The authors also suggested that recent commercial patch tests, more purified than before, might produce false negative reactions and underestimate the prevalence of photoallergy cases.…”

Section: Sensitization and Photosensitizationmentioning

confidence: 99%

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Review of the safety of octocrylene used as an ultraviolet filter in cosmetics

Berardesca

Zuberbier

Viera³

et al. 2019

Acad Dermatol Venereol

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Octocrylene or octocrilene is an organic ultraviolet (UV) filter which absorbs mainly UVB radiation and short UVA wavelengths. It is used in various cosmetic products to either provide an appropriate sun protection factor in sunscreen products or to protect cosmetic formulations from UV radiation. There is no discussion that UV filters are beneficial ingredients in cosmetics since they protect from skin cancer, but octocrylene has been recently incriminated to potentially induce adverse effects on the endocrine system in addition to having allergic and/or photoallergic potential. However, the substance has the advantage to work synergistically with other filters allowing a beneficial broad photoprotection, e.g. it stabilizes the UVA filter avobenzone (i.e. butylmethoxydibenzoylmethane). Like all chemicals used in cosmetics, the safety profile of octocrylene is constantly under assessment by the European Chemical Agency (ECHA) since it has been registered according to the European regulation Registration, Evaluation, Authorisation and Restriction of Chemicals. Summaries of safety data of octocrylene are publicly available on the ECHA website. This review aims to present the main safety data from the ECHA website, as well as those reported in scientific articles from peer‐reviewed journals. The available data show that octocrylene does not have any endocrine disruption potential. It is a rare sensitizer, photocontact allergy is more frequent and it is considered consecutive to photosensitization to ketoprofen. Based on these results, octocrylene can be considered as safe when used as a UV filter in cosmetic products at a concentration up to 10%.

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“…Scientific literature also includes several case reports, positive photopatch test studies and reviews on photoallergic reactions attributed to octocrylene …”

Section: Cutaneous Effectsmentioning

confidence: 99%

Section: Cutaneous Effectsmentioning

confidence: 99%

Section: Cutaneous Effectsmentioning

confidence: 99%