Aloe-emodin-mediated antimicrobial photodynamic therapy against multidrug-resistant Acinetobacter baumannii: An in vivo study

Wang, Yang; Li, Jiao; Geng, Songmei; Wang, Xiaopeng; Cui, Zixin; Ma, Wenpeng; Yuan, Meng; Liu, Chengcheng; Ji, Yanhong

doi:10.1016/j.pdpdt.2021.102311

Cited by 21 publications

(14 citation statements)

References 43 publications

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“…Aloe emodin has been reported to be effective against S. aureus , E. coli , A. baumannii , and C. albicans . APDT with aloe emodin resulted in a considerable reduction in the number of bacteria and fungi [ 97 , 98 , 99 ]. Moreover, Comini et al [ 96 ] investigated the APDT potential of parietin, an anthraquinone PS, with a 1000 W/m 2 light intensity.…”

Section: Natural Pss In Apdtmentioning

confidence: 99%

Natural Photosensitizers in Antimicrobial Photodynamic Therapy

2021

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Health problems and reduced treatment effectiveness due to antimicrobial resistance have become important global problems and are important factors that negatively affect life expectancy. Antimicrobial photodynamic therapy (APDT) is constantly evolving and can minimize this antimicrobial resistance problem. Reactive oxygen species produced when nontoxic photosensitizers are exposed to light are the main functional components of APDT responsible for microbial destruction; therefore, APDT has a broad spectrum of target pathogens, such as bacteria, fungi, and viruses. Various photosensitizers, including natural extracts, compounds, and their synthetic derivatives, are being investigated. The main limitations, such as weak antimicrobial activity against Gram-negative bacteria, solubility, specificity, and cost, encourage the exploration of new photosensitizer candidates. Many additional methods, such as cell surface engineering, cotreatment with membrane-damaging agents, nanotechnology, computational simulation, and sonodynamic therapy, are also being investigated to develop novel APDT methods with improved properties. In this review, we summarize APDT research, focusing on natural photosensitizers used in in vitro and in vivo experimental models. In addition, we describe the limitations observed for natural photosensitizers and the methods developed to counter those limitations with emerging technologies.

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Section: Natural Pss In Apdtmentioning

confidence: 99%

Natural Photosensitizers in Antimicrobial Photodynamic Therapy

2021

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“…AE is a newly discovered natural anthraquinone PS isolated from Chinese traditional herbs, possessing absorption in the blue region (430 nm) and singlet oxygen quantum yield of 0.57, which may be suitable for the treatment of superficial lesions (Zang et al, 2017). It was reported that AE had low cytotoxicity on epidermis and hypodermal cells and it caused no obvious effects on the weight and pathological changes of mice in our previous study (Wang et al, 2021). Thus, both HMME and AE could serve as potential PSs against M. furfur.…”

Section: Discussionmentioning

confidence: 99%

Antifungal Effect of Antimicrobial Photodynamic Therapy Mediated by Haematoporphyrin Monomethyl Ether and Aloe Emodin on Malassezia furfur

et al. 2021

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Infectious dermatological diseases caused by Malassezia furfur are often chronic, recurrent, and recalcitrant. Current therapeutic options are usually tedious, repetitive, and associated with adverse effects. Alternatives that broaden the treatment options and reduce side effects for patients are needed. Antimicrobial photodynamic therapy (aPDT) is an emerging approach that is quite suitable for superficial infections. The aim of this study is to investigate the antimicrobial efficacy and effect of aPDT mediated by haematoporphyrin monomethyl ether (HMME) and aloe emodin (AE) on clinical isolates of M. furfur in vitro. The photodynamic antimicrobial efficacy of HMME and AE against M. furfur was assessed by colony forming unit (CFU) assay. The uptake of HMME and AE by M. furfur cells was investigated by fluorescence microscopy. Reactive oxygen species (ROS) probe and flow cytometry were employed to evaluate the intracellular ROS level. The effect of HMME and AE-mediated aPDT on secreted protease and lipase activity of M. furfur was also investigated. The results showed that HMME and AE in the presence of light effectively inactivated M. furfur cells in a photosensitizer (PS) concentration and light energy dose-dependent manner. AE exhibited higher antimicrobial efficacy against M. furfur than HMME under the same irradiation condition. HMME and AE-mediated aPDT disturbed the fungal cell envelop, significantly increased the intracellular ROS level, and effectively inhibited the activity of secreted protease and lipase of M. furfur cells. The results suggest that HMME and AE have potential to serve as PSs in the photodynamic treatment of dermatological diseases caused by M. furfur, but further ex vivo or in vivo experiments are needed to verify that they can meet the requirements for clinical practice.

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“…PTT has been presented as an important noninvasive and promising alternative in the prevention of bacterial infectious diseases through the increase of local temperature (diathermia <41°C; hyperthermia 41–46°C and, thermal ablation >46°C) (Wang et al . 2021). In fact, PTT is an antibacterial method based on the generation of heat by NIR.…”

Section: Combination Of Apdt With Other Antimicrobial Agents For Biof...mentioning

confidence: 99%

Photodynamic therapy and combinatory treatments for the control of biofilm-associated infections

Ribeiro

Gomes

Saavedra

et al. 2022

Letters in Applied Microbiology

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Aloe-emodin-mediated antimicrobial photodynamic therapy against multidrug-resistant Acinetobacter baumannii: An in vivo study

Cited by 21 publications

References 43 publications

Natural Photosensitizers in Antimicrobial Photodynamic Therapy

Natural Photosensitizers in Antimicrobial Photodynamic Therapy

Antifungal Effect of Antimicrobial Photodynamic Therapy Mediated by Haematoporphyrin Monomethyl Ether and Aloe Emodin on Malassezia furfur

Photodynamic therapy and combinatory treatments for the control of biofilm-associated infections

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