Aloe-emodin prevents nerve injury and neuroinflammation caused by ischemic stroke <i>via</i> the PI3K/AKT/mTOR and NF-κB pathway

Xian, Minghua; Cai, Jiale; Zheng, Kening; Liu, Qu; Liu, Yali; Lin, Huiting; Liang, Shengwang; Wang, Shumei

doi:10.1039/d1fo01144h

Cited by 85 publications

(53 citation statements)

References 35 publications

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“…The PI3K/AKT pathway, including the mammalian target of rapamycin (mTOR), is another important signaling route mediating microglia damage [83,84]. Its activation regulates NF-κB activity in neuroinflammation [85,86].…”

Section: Neuroinflammationmentioning

confidence: 99%

Therapeutic Potential of Allicin and Aged Garlic Extract in Alzheimer’s Disease

Tedeschi

Nigro

Travagli

et al. 2022

IJMS

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Garlic, Allium sativum, has long been utilized for a number of medicinal purposes around the world, and its medical benefits have been well documented. The health benefits of garlic likely arise from a wide variety of components, possibly working synergistically. Garlic and garlic extracts, especially aged garlic extracts (AGEs), are rich in bioactive compounds, with potent anti-inflammatory, antioxidant and neuroprotective activities. In light of these effects, garlic and its components have been examined in experimental models of Alzheimer’s disease (AD), the most common form of dementia without therapy, and a growing health concern in aging societies. With the aim of offering an updated overview, this paper reviews the chemical composition, metabolism and bioavailability of garlic bioactive compounds. In addition, it provides an overview of signaling mechanisms triggered by garlic derivatives, with a focus on allicin and AGE, to improve learning and memory.

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Section: Neuroinflammationmentioning

confidence: 99%

Therapeutic Potential of Allicin and Aged Garlic Extract in Alzheimer’s Disease

Tedeschi

Nigro

Travagli

et al. 2022

IJMS

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“…Xian et al found that aloe-emodin significantly improved the infarct size and behavioral score of MCAO rats, decreased the expression of TNFα, MDA, and increased SOD. In vitro, in oxygen and glucose deprivation reperfusion (OGD/R) model of human neuroblastoma cells (SH-SY5Y) and LPS stimulated BV2 cells, AE significantly protected SH-SY5Y cells from the injury of OGD/R and reduced the production of inflammatory cytokines in BV2 cells stimulated by LPS via PI3K/AKT/mTOR and NF-κB signaling pathways [134]. In H2O2-induced apoptosis and neuroinflammation of SH-SY5Y cell, emodin exerted the similar effects on oxidative stress.…”

Section: Cerebral Vascular System and Central Nervous Systemmentioning

confidence: 99%

Effects of Anthraquinones on Immune Responses and Inflammatory Diseases

Xin

Zhou

et al. 2022

Molecules

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The anthraquinones (AQs) and derivatives are widely distributed in nature, including plants, fungi, and insects, with effects of anti-inflammation and anti-oxidation, antibacterial and antiviral, anti-osteoporosis, anti-tumor, etc. Inflammation, including acute and chronic, is a comprehensive response to foreign pathogens under a variety of physiological and pathological processes. AQs could attenuate symptoms and tissue damages through anti-inflammatory or immuno-modulatory effects. The review aims to provide a scientific summary of AQs on immune responses under different pathological conditions, such as digestive diseases, respiratory diseases, central nervous system diseases, etc. It is hoped that the present paper will provide ideas for future studies of the immuno-regulatory effect of AQs and the therapeutic potential for drug development and clinical use of AQs and derivatives.

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“…In a middle cerebral occlusion reperfusion rat model, AEM was able to reduce serum TNF-α levels, and protected rats from neurological deficits, suggesting that AEM protected the rats from neuroinflammation [ 51 ]. AEM treatment of LPS-stimulated microglial BV2 cell lines was able to inhibit the production of NO as well as pro-inflammatory cytokines IL-6 and TNF-α.…”

Section: Aloe Compounds For the Regulation Of Immune Respons...mentioning

confidence: 99%

Utilization of Aloe Compounds in Combatting Viral Diseases

Españo

Kim

2022

Pharmaceuticals

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Plants contain underutilized resources of compounds that can be employed to combat viral diseases. Aloe vera (L.) Burm. f. (syn. Aloe barbadensis Mill.) has a long history of use in traditional medicine, and A. vera extracts have been reported to possess a huge breadth of pharmacological activities. Here, we discuss the potential of A. vera compounds as antivirals and immunomodulators for the treatment of viral diseases. In particular, we highlight the use of aloe emodin and acemannan as lead compounds that should be considered for further development in the management and prevention of viral diseases. Given the immunomodulatory capacity of A. vera compounds, especially those found in Aloe gel, we also put forward the idea that these compounds should be considered as adjuvants for viral vaccines. Lastly, we present some of the current limitations to the clinical applications of compounds from Aloe, especially from A. vera.

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Aloe-emodin prevents nerve injury and neuroinflammation caused by ischemic stroke via the PI3K/AKT/mTOR and NF-κB pathway

Abstract: Ischemic stroke (IS) caused by cerebral arterial occlusion is the leading cause of global morbidity and mortality. Cellular oxidative stress and inflammation play a vital role in the pathological process...

Cited by 85 publications

References 35 publications

Therapeutic Potential of Allicin and Aged Garlic Extract in Alzheimer’s Disease

Therapeutic Potential of Allicin and Aged Garlic Extract in Alzheimer’s Disease

Effects of Anthraquinones on Immune Responses and Inflammatory Diseases

Utilization of Aloe Compounds in Combatting Viral Diseases

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