Aloe polysaccharides ameliorate acute colitis in mice via Nrf2/HO-1 signaling pathway and short-chain fatty acids metabolism

Liu, Chang; Hua, Hanyi; Zhu, Hongkang; Cheng, Yuliang; Guo, Yahui; Yao, Weirong; Qian, He

doi:10.1016/j.ijbiomac.2021.07.007

Cited by 50 publications

(25 citation statements)

References 38 publications

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“…Because BSE was rich in polysaccharides, SCFA production was obviously higher than that in DSS‐treated mice under the action of intestinal flora. SCFA production may be a reason why a variety of plant polysaccharides are effective for relieving colitis 47 …”

Section: Discussionmentioning

confidence: 99%

Broccoli seed extract rich in polysaccharides and glucoraphanin ameliorates DSS‐induced colitis via intestinal barrier protection and gut microbiota modulation in mice

Guo

Cui

et al. 2022

J Sci Food Agric

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BACKGROUND Broccoli has received widespread attention because of its anti‐inflammatory and antioxidant effects. The present study aimed to explore the composition of broccoli seed extract (BSE) and its effect on colitis induced by dextran sulfate sodium (DSS). RESULTS BSE mainly comprises glucoraphanin and polysaccharides composed of arabinose, galactose, glucose and mannose. Animal experiments suggested that BSE intervention effectively reversed body weight loss, suppressed the levels of proinflammatory interleukin‐6, tumor necrosis factor‐α and interleukin‐1β, and elevated the levels of anti‐inflammatory interleukin‐10 and the activities of superoxide dismutase and glutathione in DSS‐induced colitis mice. According to histopathologic and immunohistochemical analysis of colon tissue, BSE intervention may repair the intestinal barrier by upregulating mRNA levels and the expression of tight junction proteins (claudin‐1, occludin and zonula occludens‐1). Gas chromatography–mass spectrometry (MS) analysis demonstrated that cecal short‐chain fatty acids in mice with BSE administration were significantly increased compared with the model group. Sulforaphane and sulforaphane‐N‐acetylcysteine were only detected in BSE group mice by ultra‐performance liquid chromatography‐MS analysis. In addition, BSE intervention evidently increased the abundance of Alistipeds, Coriobacteriaceae UCG‐002 and Bifidobacterium and decreased the abundance of Escheichia‐Shinella, Lachnospiraceae others, Parabacteroides, Ruminococcaceae others and Turicibacter, which possibly promoted carbohydrate metabolism and short‐chain fatty acid production. CONCLUSION The present study aimed to elucidate the effect of BSE on colitis and found that BSE, as a novel food ingredient, has great potential for the improvement of colitis. © 2022 Society of Chemical Industry.

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Section: Discussionmentioning

confidence: 99%

Broccoli seed extract rich in polysaccharides and glucoraphanin ameliorates DSS‐induced colitis via intestinal barrier protection and gut microbiota modulation in mice

Guo

Cui

et al. 2022

J Sci Food Agric

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“…Among them, propionate can prevent weight gain and lipid content in liver cells. SCFAs metabolism is one of the potential mechanisms of polysaccharide treatment to reduce inflammation in mice [ 43 ]. The results support that CIP ameliorates obesity in mice by correcting intestinal microbial metabolic disorders induced by HFD.…”

Section: Discussionmentioning

confidence: 99%

Isinglass Polysaccharides Regulate Intestinal-Barrier Function and Alleviate Obesity in High-Fat Diet Mice through the HO-1/Nrf2 Pathway and Intestinal Microbiome Environment

Liu

Zhang

et al. 2022

Nutrients

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Plant polysaccharide intervention has shown significant potential to combat obesity. However, studies on animal polysaccharides are indeed rare. The aim of this study was to investigate the potential functions of CIP (IL) on obesity, intestinal microflora dysbiosis, and the possible protection of intestinal barrier in mice fed with high-fat diet (HFD). Our results revealed that after 13 weeks, the HFD+L (high-fat diet + 25 mg/kg CIP) group showed significantly more weight loss and fat accumulation relative to the HFD+H (high-fat diet + 50 mg/kg CIP) group. Furthermore, CIP intervention modulated lipid metabolism and mRNA levels of inflammatory mediators in liver. Overall, CIP clearly improved the intestinal barrier in HFD-fed mice. Additionally, we observed that CIP intervention improved intestinal microbiota community richness and diversity in HFD-fed mice. The CIP intervention mice group showed a relatively low Firmicutes to Bacteroidetes ratio compared to the HFD group. This study concluded that CIP could be used as a functional food to prevent adipocyte accumulation, reduce systemic inflammation, and protect the intestinal barrier.

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“…SASP has been widely used in the management of patients with colitis by inhibiting inflammatory cytokines (Gan, Chen, & Ouyang, 2005). The dosage of polysaccharides and SASP given to rats was according to previous reports (Liu et al, 2021; Yang et al, 2016). The positive control group was treated with SASP for three consecutive days after 4% acetic acid induction.…”

Section: Methodsmentioning

confidence: 99%

Rhinacanthus nasutus and okara polysaccharides attenuate colitis via inhibiting inflammation and modulating the gut microbiota

Chen

Shen

Lin

et al. 2022

Phytotherapy Research

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Plant polysaccharides have prebiotic properties for gut microbiota and immune modulation. This study aimed to investigate the prevention abilities of edible Rhinacanthus nasutus polysaccharide (RNP) and okara polysaccharide (OP) in Sprague-Dawley rats with acetic acid-induced colitis. The characterizations of RNP and OP were analyzed, including Fourier transform infrared, thermogravimetric analysis, differential scanning calorimetry, and monosaccharide composition. The prebiotic properties of RNP and OP were determined in vitro. In addition, the pathological features of colon length and inflammatory cytokine levels in acetic acid-induced colitis were improved by intragastric preadministration of RNP and OP for 3 weeks. There was no nephrotoxicity or hepatotoxicity in rats via histopathological assessment after RNP and OP intake. Moreover, the abundance of short-chain fatty acids-producing bacteria (Lachnospiraceae, Lactobacilli, and Prevotellaceae) were increased after RNP supplementation. In conclusion, intragastric gavage of RNP and OP significantly modulated the gut microbiota and immune response, consequently alleviating the symptoms of colitis. This novel finding provides an alternative strategy and potential application of these two polysaccharides for colitis prevention and treatment.

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Aloe polysaccharides ameliorate acute colitis in mice via Nrf2/HO-1 signaling pathway and short-chain fatty acids metabolism

Cited by 50 publications

References 38 publications

Broccoli seed extract rich in polysaccharides and glucoraphanin ameliorates DSS‐induced colitis via intestinal barrier protection and gut microbiota modulation in mice

Broccoli seed extract rich in polysaccharides and glucoraphanin ameliorates DSS‐induced colitis via intestinal barrier protection and gut microbiota modulation in mice

Isinglass Polysaccharides Regulate Intestinal-Barrier Function and Alleviate Obesity in High-Fat Diet Mice through the HO-1/Nrf2 Pathway and Intestinal Microbiome Environment

Rhinacanthus nasutus and okara polysaccharides attenuate colitis via inhibiting inflammation and modulating the gut microbiota

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