Alopecia areata and lnterleukin-2 Receptor

Valsecchi, R; Imberti, G.; Martino, David; Cainelli, T.

doi:10.1159/000247519

Cited by 15 publications

(8 citation statements)

References 10 publications

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“…In the above study, higher soluble IL-2R levels in PBMC from PAA patients were shown, in agreement with the findings of Valesecchi et al 7 in affected hair follicles. We found significantly increased levels of IL-5 in PAA, also expressing a Th2 response.…”

Section: Reportsupporting

confidence: 92%

In vitro cytokine profile in childhood alopecia areata and the immunomodulatory effects of AS-101

et al. 2005

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The aim of the present study was to determine the effect of AS-101, a known immunomodulator, on the pattern of cytokine production in children with patchy alopecia areata (PAA). Ten previously untreated children with PAA were compared to 10 healthy age- and sex-matched controls. Peripheral blood mononuclear cells (PBMC) were isolated from all participants. Unstimulated and phytohaemagglutinin (PHA)-stimulated PBMC were tested with and without the addition of AS-101. The production of interferon gamma (IFNgamma), soluble interleukin (IL)-2 receptor (IL-2R), IL-10, IL-5 and IL-6 was determined. The levels of soluble IL-2R, IL-5 and IL-6 were significantly higher in the PAA patients than the controls. AS-101 inhibited the production of IL-10, IFNgamma, IL-2R and IL-5 in both PAA patients and controls, but there was a greater inhibitory effect in children with PAA.

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Section: Reportsupporting

confidence: 92%

In vitro cytokine profile in childhood alopecia areata and the immunomodulatory effects of AS-101

et al. 2005

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“…The immune response presented in AA is associated with aberrant lesional expression of interferon-γ, IL-2, and IL-1β, and overexpression of ICAM-1 and major histocompatibility complex molecules on hair follicle keratinocytes and dermal papilla cells [14]. Several clinical and experimental findings point towards IL-2 as a crucial mediator inducing immunologic reaction against human follicle in AA [15, 16]. By using semiquantitative reverse transcription-polymerase chain reaction with RNA extracted from scalp biopsies from patients with AA, Hoffmann et al [17] reported that IL-2 mRNA levels were increased in untreated AT.…”

Section: Discussionmentioning

confidence: 99%

Serum Levels of Interleukin-2 in Patients with Alopecia Areata: Relationship with Clinical Type and Duration of the Disease

Kasumagić-Halilovic

Čavaljuga

Ovčina-Kurtović

et al. 2018

Skin Appendage Disord

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Background: Alopecia areata (AA) is a disease characterized by focally, nonscarring hair loss on the scalp or any hair-bearing surface. The etiology is unknown, although the evidence suggests that AA is an immunologically mediated disease. In the pathogenesis of AA, Th1 immune response is predominant. A special cytokine profile is created by Th1 cells, which disturbs the natural balance of the cytokine networks and leads to inflammatory reaction and follicle damage. Objective: The aim of our study was to evaluate serum concentrations of IL-2 in patients with AA and healthy subjects. We also examined a possible association between serum levels of IL-2, disease severity, and duration of AA. Methods: Sixty patients with AA and 20 healthy controls were enrolled in the study. Serum concentrations of IL-2 were measured using enzyme-linked immunoassay techniques. Results: Comparison of mean values of IL-2 has showed that serum concentrations of this cytokine are significantly higher in serum samples of AA patients in relation to the control group (22.2 ± 1.19 vs. 21.1 ± 2.68 pg/mL, respectively; p = 0.0142). No correlations were found between clinical type, duration of the disease, and serum levels of IL-2. Conclusion: Our findings support the evidence that elevation of serum IL-2 is associated with AA. The exact role of serum IL-2 in AA should be additionally investigated in future studies.

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“…Proportionate elevation of sIL-2R serum concentration to illness intensity was observed in diseases such as psoriasis (De Rie et al 1996, Elkayam et al 2000, atopic dermatitis (Colver et al 1989, Gebhardt et al 1997, Halmerbauer et al 1997, Leonardi et al 2004, chronic urticaria (Serhat Inaloz et al 2008), erythema multiformae (Chodorowska et al 2003), pemphigus (Zillikens et al 1993), alopecia areata (Shohat et al 2005, Valsecchi et al 1992) and in nodular erythema (Chodorowska et al 2003). To the best of our knowledge our results are the first on sIL-2R serum concentration in HS patients.…”

Section: Discussionmentioning

confidence: 99%

Soluble interleukin-2 receptor serum level is a useful marker of hidradenitis suppurativa clinical staging

2009

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Hidradenitis suppurativa (HS) is a recurrent, debilitating suppurative skin disease. The major challenge is the choice of optimal treatment. Assessment of treatment effectiveness is currently associated with clinical observations of disease activity based on Hurley's or Sartorius' grading system. Detailed examination of patients with HS and evaluation of disease severity is frequently time-consuming and undoubtedly subjective. With regard to these factors, there is a need for laboratory findings that will help resolve the problem. The aim of this study was to determine the usefulness of soluble interleukin-2 receptor (sIL-2R) serum concentration as a marker of HS clinical staging and comparative analysis with the commonly conducted laboratory measurements, including white blood cell count, C-reactive protein and erythrocyte sedimentation rate. The statistical analysis of all these laboratory parameters conducted within a group of 54 individuals with HS revealed that sIL-2R serum level seems to be the most sensitive measurement for evaluation of disease stage. Moreover, the existence of strong dependences between sIL-2R serum concentration and Hurley's HS grading system were demonstrated. In conclusion, we believe that sIL-2R serum level could be used as a valuable marker for disease staging in patients with HS.

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Alopecia areata and lnterleukin-2 Receptor

Cited by 15 publications

References 10 publications

In vitro cytokine profile in childhood alopecia areata and the immunomodulatory effects of AS-101

In vitro cytokine profile in childhood alopecia areata and the immunomodulatory effects of AS-101

Serum Levels of Interleukin-2 in Patients with Alopecia Areata: Relationship with Clinical Type and Duration of the Disease

Soluble interleukin-2 receptor serum level is a useful marker of hidradenitis suppurativa clinical staging

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