Alopecia in association with severe seborrhoeic dermatitis following combination antiretroviral therapy for acute retroviral syndrome

Hardcastle, N. J.; Tunbridge, A.; Shum, KW; Dockrell, David H.; St, Green

doi:10.1111/j.1468-3083.2005.01240.x

Cited by 14 publications

(14 citation statements)

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“…Seborrhoeic dermatitis (localized and not severe or atypical) was the commonest IRIS condition in our study but has only once been previously described as an example of IRIS, when it was coupled with alopecia and occurred 1 month after HAART being started for acute retroviral syndrome 8 . Seborrhoeic dermatitis has been reported in up to 83% of people infected with HIV, so its presence as an IRIS event could be expected.…”

Section: Discussionmentioning

confidence: 50%

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Immune reconstitution inflammatory syndrome involving the skin

Osei-Sekyere¹,

Karstaedt²

2009

Clinical and Experimental Dermatology

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Section: Discussionmentioning

confidence: 50%

“…Seborrhoeic dermatitis has been reported in up to 83% of people infected with HIV, so its presence as an IRIS event could be expected. Its aetiology is poorly understood, but there is an association with Malassesia furfur infection, against which the inflammatory component of IRIS may be directed 8 …”

Section: Discussionmentioning

confidence: 99%

Immune reconstitution inflammatory syndrome involving the skin

Osei-Sekyere¹,

Karstaedt²

2009

Clinical and Experimental Dermatology

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“…The cross-sectional nature of the measurements of blood metals and personal behaviors (for example, sleep patterns [67], [68], [70], [94] and oily scalp [62], [95], [96], [97], [98], [99], [100]) limit our ability to identify causal relationships; the time of onset of moderate to severe hair loss will need more investigation in future work.…”

Section: Discussionmentioning

confidence: 99%

Androgenic Alopecia Is Associated with Less Dietary Soy, Higher Blood Vanadium and rs1160312 1 Polymorphism in Taiwanese Communities

et al. 2013

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BackgroundAlthough the genetic basis of androgenic alopecia has been clearly established, little is known about its non-genetic causes, such as environmental and lifestyle factors.ObjectiveThis study investigated blood and urine heavy metals concentrations, environmental exposure factors, personal behaviors, dietary intakes and the genotypes of related susceptibility genes in patients with androgenic alopecia (AGA).DesignAge, AGA level, residence area, work hours, sleep patterns, cigarette usage, alcohol consumption, betel nut usage, hair treatments, eating habits, body heavy metals concentrations and rs1998076, rs913063, rs1160312 and rs201571 SNP genotype data were collected from 354 men. Logistic regression analysis was performed to examine whether any of the factors displayed odds ratios (ORs) indicating association with moderate to severe AGA (≧IV). Subsequently, Hosmer-Lemeshow, Nagelkerke R2 and accuracy tests were conducted to help establish an optimal model.ResultsModerate to severe AGA was associated with the AA genotype of rs1160312 (22.50, 95% CI 3.99–126.83), blood vanadium concentration (0.02, 95% CI 0.01–0.04), and regular consumption of soy bean drinks (0.23, 95% CI 0.06–0.85), after adjustment for age. The results were corroborated by the Hosmer-Lemeshow test (P = 0.73), Nagelkerke R2 (0.59), accuracy test (0.816) and area under the curve (AUC; 0.90, 0.847–0.951) analysis.ConclusionsBlood vanadium and frequent soy bean drink consumption may provide protect effects against AGA. Accordingly, blood vanadium concentrations, the AA genotype of rs1160312 and frequent consumption of soy bean drinks are associated with AGA.

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“…108 Response to antiretroviral treatment is variable and there have been conflicting reports in the literature: some investigators reported an improvement in SD with the initiation of antiretroviral treatment, while others reported aggravation. 109,110 Furthermore, there have been reports of aggravation during immune reconstitution inflammatory syndrome and reports that antiretroviral treatment does not alter the prevalence or the course of SD. 111,112 With respect to histopathology, the findings of SD in HIV-positive patients are similar to those found in HIV-negative patients; however, there appears to be greater follicular involvement in the lesions and more plasmocytes in the inflammatory infiltrate in the HIVpositive patients.…”

Section: Seborrheic Dermatitis and Hivmentioning

confidence: 99%

Dermatite seborreica

Sampaio

Mameri²,

Vargas

et al. 2011

An. Bras. Dermatol.

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Seborrheic dermatitis is a chronic relapsing erythematous scaly skin disease, the prevalence of which is around 1 to 3% of the general population in the United States. It has two incidence peaks, the first in the first three months of life and the second beginning at puberty and reaching its apex at 40 to 60 years of age. The prevalence of seborrheic dermatitis is higher in HIV-positive individuals and the condition tends to be more intense and refractory to treatment in these patients. Neurological disorders and other chronic diseases are also associated with the onset of seborrheic dermatitis. The currently accepted theory on the pathogenesis of this disease advocates that yeast of Malassezia spp., present on the skin surface of susceptible individuals, leads to a non-immunogenic irritation due to the production of unsaturated fatty acids deposited on the skin surface. This article provides a review of the literature on seborrheic dermatitis, focusing on immunogenetics, the clinical forms of the disease and its treatment. . Keywords: Dermatitis; Dermatitis, seborrheic; Eczema Resumo: A dermatite seborreica é uma doença eritêmato-escamativa de caráter crônico-recidivante que acomete entre 1 e 3% da população geral dos Estados Unidos. Possui dois picos de incidência -o primeiro, durante os três primeiros meses de vida, e o segundo, a partir da puberdade, atingindo seu ápice entre os 40 e 60 anos de idade. Os indivíduos HIV positivos têm maior prevalência da doença, que apresenta maior intensidade e tendência à refratariedade ao tratamento. Doenças neurológicas e outras doenças crônicas também estão associadas ao desenvolvimento da dermatite seborreica. Como mecanismo fisiopatogênico, reconhece-se que o fungo Malassezia sp., presente na pele de indivíduos suscetíveis, leve a uma irritação não-imunogênica a partir da produção de metabólitos à base de áci-dos graxos insaturados deixados na superfície cutânea. Este artigo faz uma revisão da literatura sobre dermatite seborreica, com ênfase nos aspectos imunogenéticos, formas clínicas e tratamento.

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Alopecia in association with severe seborrhoeic dermatitis following combination antiretroviral therapy for acute retroviral syndrome

Cited by 14 publications

References 10 publications

Immune reconstitution inflammatory syndrome involving the skin

Immune reconstitution inflammatory syndrome involving the skin

Androgenic Alopecia Is Associated with Less Dietary Soy, Higher Blood Vanadium and rs1160312 1 Polymorphism in Taiwanese Communities

Dermatite seborreica

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