Alopecia totalis sparing congenital melanocytic nevus: Renbök phenomenon

Yamamoto, Toshiyuki; Okabe, Hideko; Hoshi, Michiko

doi:10.4103/ds.ds_38_18

Cited by 3 publications

(4 citation statements)

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“…to describe retained hair growth localized to psoriatic plaques in a patient with coexisting psoriasis and alopecia areata (AA). Subsequently, cases of AA sparing congenital melanocytic naevi and naevus flammeus have also been described 2 . We present the observation of continued hair growth in a vascular naevus in an area otherwise affected by frontal fibrosing alopecia (FFA), an uncommon scarring alopecia characterized by lymphocytic follicular inflammation and hair follicle stem cell destruction, giving further evidence to the occurrence of the Renbök phenomenon.…”

Section: Figurementioning

confidence: 77%

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Frontal fibrosing alopecia sparing a vascular naevus: the Renbök phenomenon

Nemazee

Harries

2021

Clin Exp Dermatol

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Section: Figurementioning

confidence: 77%

“…The mechanism underlying the Renbök phenomenon is not entirely clear, although a number of potential explanations have been proposed 2–4 . Most likely in our case is that the vascular naevus is a genetic mosaic exhibiting genetically determined resistance and a specific microenvironment that protects the hairs from inflammatory destruction.…”

Section: Figurementioning

confidence: 78%

Frontal fibrosing alopecia sparing a vascular naevus: the Renbök phenomenon

Nemazee

Harries

2021

Clin Exp Dermatol

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“…In this context, our data points to future hair growth-stimulating therapies in which select SASP factors, such as SPP1 or its CD44-binding derivatives, are injected into hair loss-affected skin. In support of this approach are clinical cases reporting hair loss-resistant melanocytic nevi on the scalp of patients with alopecia, including alopecia universalis 40 .…”

Section: Discussionmentioning

confidence: 97%

Signalling by senescent melanocytes hyperactivates hair growth

Wang,

Ramos,

Phan

et al. 2023

Nature

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Niche signals maintain stem cells in a prolonged quiescence or transiently activate them for proper regeneration1. Altering balanced niche signalling can lead to regenerative disorders. Melanocytic skin nevi in human often display excessive hair growth, suggesting hair stem cell hyperactivity. Here, using genetic mouse models of nevi2,3, we show that dermal clusters of senescent melanocytes drive epithelial hair stem cells to exit quiescence and change their transcriptome and composition, potently enhancing hair renewal. Nevus melanocytes activate a distinct secretome, enriched for signalling factors. Osteopontin, the leading nevus signalling factor, is both necessary and sufficient to induce hair growth. Injection of osteopontin or its genetic overexpression is sufficient to induce robust hair growth in mice, whereas germline and conditional deletions of either osteopontin or CD44, its cognate receptor on epithelial hair cells, rescue enhanced hair growth induced by dermal nevus melanocytes. Osteopontin is overexpressed in human hairy nevi, and it stimulates new growth of human hair follicles. Although broad accumulation of senescent cells, such as upon ageing or genotoxic stress, is detrimental for the regenerative capacity of tissue4, we show that signalling by senescent cell clusters can potently enhance the activity of adjacent intact stem cells and stimulate tissue renewal. This finding identifies senescent cells and their secretome as an attractive therapeutic target in regenerative disorders.

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“…Persons of foreign origin (foreign-born or with two foreign-born parents) constituted 25.5%, 13.8% and 18.2% of the population in Sweden, Denmark and Norway, respectively, in 2020, and more than half of these were of "non-Western origin" (as defined by national statistical services [5][6][7] ). [5][6][7] Recently, Swedish medical students and doctors have highlighted a lack of information on skin of color dermatology (also referred to as "ethnic dermatology"), perpetuating bias and slowing efforts towards health equity. The aim of this investigation was to find out if the content of dermatology textbooks used by medical students in Scandinavia reflect the ethnic diversity of the population.…”

Section: Dermatology Textbooks In Scandinavia Should Prepare Medical Students For Ethnic Diversitymentioning

confidence: 99%