Alpha‐1 antitrypsin (AAT) and alphafoetoprotein (AFP) in sera of patients with germ‐cell neoplasms: Value as tumour markers in patients with endodermal sinus tumour (yolk sac tumour)

Abstract

Serum alphafoetoprotein (AFP) and serum alpha-1 antitrypsin (AAT) were determined in 24 patients with germ-cell neoplasms of the gonads and extragonadal sites and in two patients with hepatocellular carcinoma. In the majority of the patients serial determinations were performed. All seven patients with testicular seminoma and four patients without evidence of active disease had normal levels of serum AAT and AFP. The remaining 13 patients with germ-cell neoplasms had tumours containing endodermal sinus tumour (yolk-sac tumour) elemetns. All these 13 patients had elevated levels of serum AFP and the levels were high or very high in most cases. Nine of these 13 patients had raised serum AAT, although the elevation above normal levels was only slight in a number of cases. When serial determinations were performed serum AAT levels frequently followed the pattern of serum AFP levels, but the AAT levels were frequently within normal limits and therefore the interpretation of the results was difficult, and much less reliable as compared with those for serum AFP. The elevation of serum AAT levels following the recurrence of the tumour was found to occur much later and was much less marked than elevation of serum AFP, which occurred early, showed a large rise and was a reliable marker of tumour recurrence in patients with germ-cell neoplasms containing endodermal sinus tumour elements. It is therefore considered that, although there is good evidence that serum AAT is produced by endodermal sinus tumour elements, serum AAT is not a useful monitor of disease activity in these patients, especially when compared with serum AFP, the value of which is well recognized. Serum AAT may be a useful tumour marker in patients with hepatocellular carcinoma, and this aspect should be investigated further.

Alpha‐1 Antitrypsin (AAT) and Alpha‐fetoprotein (AFP) in Sera of Patients with Germ Cell Neoplasm

“…This is well illustrated in Fig. 1 Table I shows the results of 71 determinations of both AFP and AAT in serum of the group of patients from this preceding study [8].…”

“…In addition to the 24 patients with germ cell tumours of the gonads and extragonadal sites who were studied by Talerman et al [8], serial determinations of AAT and AFP have been performed in the serum of 9 patients with neoplasms which were not of germ cell origin. These patients were treated with radiotherapy and/or chemotherapy.…”

“…In a recent study Talerman et al [8] compared the value of AFP and AAT as tumour markers in a group of patients with germ cell neoplasms containing endodermal sinus tumour elements. These authors concluded that serum AAT is not a useful monitor of disease activity, especially when compared with serum AFP.…”

Endodermal sinus tumor of the vagina in children

“…de Camargo. Talerman et al [19] first emphasized the usefulness of monitoring the serum levels of alpha-fetoprotein (AFP) in patients with germ-cell tumors. AFP surveillance is extremely sensitive.…”

Immunohistochemical Localisation of Alpha-Fetoprotein (AFP) in Germ Cell Tumours: Evidence for AFP Production by Tissues Different from Endodermal Sinus Tumour

“…This assumption has been verified by two dif ferent approaches: (a) Histopathological examination of tissue sections regularly revealed the presence of EST in patients with elevated serum AFP concentra tions [14,15]. (b) AFP was demonstrated by im munohistochemical techniques in tissue sections of both pure EST [5,17] as well as EST containing mixed germ cell tumours [9,18].…”