Alpha-Amylase, Maltase and Sucrase Inhibitions by Aqueous Leaf Extracts of Anacardium occidentale (Anacardiacea) and Piliostigma reticulatum (Caesalpiniaceae) in Rats

Gidado, Abubakar; Watafua, Miriam; Sa’ad, Rabiu; Tagi, Hafsat; Abdullahi, Suleiman

doi:10.26538/tjnpr/v3i6.5

Cited by 9 publications

(13 citation statements)

References 18 publications

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“…Groups IV, V, VI and VII were administered simultaneously, starch (2 g/kg) and solvent leaf fractions (n-hexane, dichloromethane, ethyl acetate and methanol) of at 200 mg/kg respectively. Setaria megaphylla All administrations were done orally and blood glucose concentration was monitored at 30, 60, 90, 120 and 180 min (Gidado et al, 2019).…”

Section: Animalsmentioning

confidence: 99%

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Inhibitory effect of leaf fractions of Setaria megaphylla on alpha amylase and alpha glucosidase activities in rats

Okokon¹,

Davies²,

John³

et al. 2021

Adv Pharm J

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Objective: Setaria megaphylla (Steud) Dur & Schinz (Poaceae), a perennial grass used traditionally in the treatment of various diseases including diabetes was evaluated for effect on alpha amylase and alpha glucosidase enzymes. Materials and methods: The leaf fractions (hexane, dichloromethane, ethyl acetate, methanol, 200 mg/kg) of Setaria megaphylla in vivo were evaluated for inhibitory effect on alpha amylase and alpha glucosidase enzymes using starch, sucrose and maltose as substrates. Acarbose was used as referenced drug.The leaf fractions Results: caused significant (p<0.05) reduction in blood glucose levels of treated with the various substrates used. -hexane n fraction exerted the highest inhibitory effect when starch and sucrose were used as substrates followed by methanol. Methanol was the most active fraction followed by hexane when maltose was used as substrate. The results suggest that the leaf fractions of have the potentials to inhibit alpha amylase and glucosidases in rats.

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Section: Animalsmentioning

confidence: 99%

“…The procedure as described above was used for this study but with sucrose and maltose used as substrates (Gidado et al, 2019).…”

Section: Glucosidase Inhibitory Studymentioning

confidence: 99%

Inhibitory effect of leaf fractions of Setaria megaphylla on alpha amylase and alpha glucosidase activities in rats

Okokon¹,

Davies²,

John³

et al. 2021

Adv Pharm J

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show abstract

“…This may be due to the phytochemical composition of the dose which has a higher amount of FS compared to combinations 1 and 3. 22 In the study of Musfiroh et al (2019), 23 the ethanol extract of FS, MS and BCS contain alkaloids, flavonoids, monoterpenes and sesquiterpenes. 23,18 Polyphenols, especially flavonoids have the important property of inhibiting alpha-amylase and alpha-glucosidase.…”

Section: Inhibition Of α-Amylase Activity Using In Vitro Assaymentioning

confidence: 98%

Alpha-Amylase Inhibitory Activity of Extract Combination of Morinda citrifolia L. Fruit, Trigonella foenum-graecum and Nigella sativa L. Seeds Using In vitro and In Vivo Assay

2020

TJNPR

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Maintaining glycemic control in Diabetes Mellitus (DM) is necessary to prevent many health complications, mortality, and morbidity. 1 There are various pharmacological approaches used in DM therapy such as delay the digestion and absorption of carbohydrates in the gastrointestinal system by inhibiting alpha-amylase and alphaglucosidase activity. 2 Alpha-amylase will converts polysaccharides in the mouth and intestines into the disaccharide molecule, then the reaction will be continued by alpha-glucosidase to produce glucose units that will be absorbed into the body. 3 This inhibition can lessen postprandial hyperglycemia and prevent diabetic complications. 4 There are many studies about the alpha-amylase inhibitory activity of plants and their bioactive compounds in vitro, but few studies confirm these findings in rodents and very few in humans. 5 In vivo and in vitro studies may not always be correlated, but in vitro data can be used to determine the activity of compounds before use in in vivo studies to determine physiological and pharmacological effects in animals. 6 Based on the previous study, the ethanol extract of Fenugreek seeds (FS), Morinda Fruit (MS), and Black Cumin Seeds (BCS) were reported to have antidiabetic activity, 7-9 but there were no reports regarding the inhibitory activity of alpha-amylase from the combined

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“…Groups IV,V and VI were administered simultaneously, starch (2 g/kg) and extract at 187, 374 and 516 mg/kg respectively Zea mays while groups VII-X rats were administered starch (2 g/kg) and fractions (n-hexane, dichloromethane, ethyl acetate and methanol) at 374 mg/kg respectively. All administrations were done orally and blood glucose concentration was monitored at 30, 60, 90, 120 and 180 min (Gidado et al, 2019).…”

Section: Animalsmentioning

confidence: 99%

“…In vivo glucosidase inhibitory study Similar procedure described above was employed for this study with sucrose and maltose used as substrates (Gidado et al, 2019).…”

Section: Animalsmentioning

confidence: 99%

In vivo inhibitory activities of husk extract and fractions of Zea mays on alpha amylase and alpha glucosidase

Okokon¹,

Enin²,

Nyong³

et al. 2021

Adv Pharm J

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Objective:husk is used in Ibibio traditional medicine for the treatment of various ailments including Zea mays diabetes mellitus, malaria and ulcer. Aim of present study was to investigate inhibitory activities of husk extract and fractions of on alpha amylase and alpha glucosidase.The husk extract (187-561 Zea maysMaterial and methods: mg/kg) and fractions (n-hexane, dichloromethane, ethyl acetate and methanol,374 mg/kg) of were Zea mays evaluated in rats for inhibitory effect on alpha amylase and alpha glucosidase enzymes using starch, sucrose and maltose as substrates. Acarbose was used as referenced drug.The husk extract caused significant (p<0.05) Results: reduction in blood glucose levels of treated rats though non dose-dependently with the various substrates used. The methanol fraction followed by ethyl acetate fraction exerted the highest inhibitory effect when starch and sucrose were used as substrates, while DCM fraction was the most active fraction when maltose was used as substrate. Conclusion: The results suggest that the husk and fractions of have the potentials to inhibit alpha amylase and Z. Mays glucosidase in rats.

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Alpha-Amylase, Maltase and Sucrase Inhibitions by Aqueous Leaf Extracts of Anacardium occidentale (Anacardiacea) and Piliostigma reticulatum (Caesalpiniaceae) in Rats

Cited by 9 publications

References 18 publications

Inhibitory effect of leaf fractions of Setaria megaphylla on alpha amylase and alpha glucosidase activities in rats

Inhibitory effect of leaf fractions of Setaria megaphylla on alpha amylase and alpha glucosidase activities in rats

Alpha-Amylase Inhibitory Activity of Extract Combination of Morinda citrifolia L. Fruit, Trigonella foenum-graecum and Nigella sativa L. Seeds Using In vitro and In Vivo Assay

In vivo inhibitory activities of husk extract and fractions of Zea mays on alpha amylase and alpha glucosidase

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